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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 3 | Optimization of Diesel,Methyl Tallowate and Ethanol Blend for Reducing Emissions from Diesel Engine显示文摘 | Ali Y Hanna M A Borg J E | 1995 | Bioresource Technology1995，52，： | 1 |
| 4 | Selected functionalproperties of extruded starch acetate and natural fibers foams显示文摘 | Guan J Fang Q Hanna M A | 2004 | Cereal Chem2004，81，： | 1 |
| 5 | MicroRNAs are associated with human embryo implantation defects 显示文摘 | Revel A Achache Hanna Stevens J | 2011 | Hum Reprod2011，26，10： | 1 |
| 6 | Functional Properties of Ex- truded Foam Composites of Starch Acetate and Corn Cob Fiber显示文摘 | GUAN J HANNA M A | 2004 | Industrial Crops and Products2004，19，3： | 1 |
| 7 | Vibrational spectroscopic study of structural changes in isotactic polypropylene below the melting point显示文摘 | HANNA L A HENDRA P J MADDAMS W | 1988 | Polymer1988，29，10： | 1 |
| 8 | Soybean and Sunflower Oil Performance in a Diesel Engine 显示文摘 | SCHLICK M L HANNA M A SCHINSTOCK J L | 1988 | Trans ASAE1988，31，5： | 1 |
| 9 | Characterizaiton of aqueous humie substances before and after chlorination 显示文摘 | Hanna J V Johnson W D Quezada R A | 1991 | Environ Sci Tech1991，25，6： | 1 |
| 10 | Kinetics of a reactive dye adsorption onto dolomiticsorbents 显示文摘 | WALKER G M HANSEN J HANNA J A | 2003 | Water Res2003，37，9： | 1 |
| 11 | The effect of intravenous opioid patient-controlled analgesia with and without background infusion on respiratory depression: a Meta-analysis显示文摘 | GEORGE J A LINE E HANNA M N | 2010 | J Opioid Manag2010，6，1： | 1 |
| 12 | Influence of cultivar nitrogen and frequency of insecticide application on vegetable leafminer (Diptera:Agromyzidae) population density and dispersion on snap beans显示文摘 | Hanna H Y Story R N Adams A J | 1987 | Journal of Economic Entomology1987，80，1： | 1 |
| 13 | Splittability over Semigroups 显示文摘 | HANNA A J MCMASTER T B M | 2006 | Semigroup Forum2006，73，： | 1 |
| 14 | The role of matrix metalloproteinase in the oral environment显示文摘 | Hannas A R Pereira J C Granjeiro J M | 2007 | Acta Odomol Seand2007，65，1： | 1 |
| 15 | Medic01egal aspects of testicular torsion显示文摘 | Matteson J R Stock J A Hanna M K | 2001 | Urology2001，57，： | 1 |
| 16 | Phylogenetic and molecular characteristics of Eurasian H9 avian influenza viruses and their detection by two different H9-specific RealTime reverse transcriptase polymerase chain reaction tests显示文摘 | Slomka M J Hanna A Mahmood S | 2013 | Veterinary Microbiology2013，162，4： | 1 |
| 17 | Registration of 'Tift 94' bermudagrass显示文摘 | Hanna W W Carrow R N Powell A J | 1997 | Crop Sci1997，37，： | 1 |
| 18 | Lithium intercalation into the titanosilicate sitinakite 显示文摘 | MILNE N A GRIFFITH C S HANNA J V | 2006 | Chemistry of Materials2006，18，14： | 1 |
| 19 | Art Outbreak of Japanese encephalitis in the Tones Strait, Australia, 1995 显示文摘 | HANNA J N RITCHIE S A PHILLIPS D A | 1996 | Med J Aust1996，165，5： | 1 |
| 20 | 显示文摘 | Cha J Y Hanna M A | 2002 | Industrial Crops and Products2002，16，： | 1 |
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