|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 2 | Online Haggling at a Name - Your - Own - Price Retailer: Theory and Application显示文摘 | TERWIESCH C SAVIN S HANN I | 2005 | Man- agement Science2005，51，3： | 1 |
| 3 | How to monitor semi-natural key habitats in relation to grazing preferences of cattle in mountain summer farming areas an aerial photo and GPS method study显示文摘 | Hanne S Margareta I Ann N | 2004 | Landscape and Urban Planning2004，67，： | 1 |
| 4 | Understanding the motivations, participation and performance of open source software developers: a longitudinal study of the a- pache projects 显示文摘 | ROBERTS J HANN I H SLAUGHTER S | 2006 | Management Science2006，52，7： | 1 |
| 5 | Price Discrimination in E - Commerce? An Examination of Dynamic Pricing in Name - Your - Own Price Markets显示文摘 | HINZ O HANN I SPANN M | 2011 | MIS Quarterly2011，35，1： | 1 |
| 6 | Overcoming online information privacyconcerns: an information -processing theory approach 显示文摘 | Hann I Hui K Lee S T | 2007 | Journal ofManagement Information System2007，，2： | 1 |
| 7 | Lipid-based amphotericin B:a review of the last 10 years of use显示文摘 | Hann I M Prentice H G | 2001 | Intern J Antimicrob Agents2001，17，3： | 1 |
| 8 | Price dispersion and differentiation in online travel:an empirical investigation显示文摘 | E K Clemons I H Hann L M Hitt | 2002 | Management Science2002，，4： | 1 |
| 9 | Consumer privacy and mar-keting avoidance: a static model显示文摘 | HANN I H HUI Kai-Lung LEE S Y T | 2008 | Management Science2008，54，6： | 1 |
| 10 | Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric ( ALL97 ) and adult ( UKALLXII/E2993 ) trials显示文摘 | Ramanujachar R Richards S Hann I | 2007 | Pediatr Blood Cancer2007，48，3： | 1 |
| 11 | Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a proective study显示文摘 | Neth O Hann I Turner MW | 2001 | Lancet2001，358，9282： | 1 |
| 12 | Replication and cytolysis of an E1B-attenuated adenovirus in drug-resistant ovarian tumour cells is associated with reduced apoptosis显示文摘 | Kim YT Hann B | 2001 | Gene Ther2001，8，5： | 1 |
| 13 | Online haggling at a name- your- own- price retailer :theory and appli- cation 显示文摘 | TERWIECH C HANN I H SAVIN S | 2005 | Management Sci2005，51，3： | 1 |
| 14 | CNs-directed therapy for childhood acute lymphoblasticleukemia,childhood ALL collaborative group overview of 43 randomized trials显示文摘 | Clarke M Gaynon P Hann I | 2003 | J Clin Oncol2003，21，： | 1 |
| 15 | Validation of the healthy eating index with use of plasma biomarkers in clinical sample of women 显示文摘 | HANN C S ROCK C L KING I | 2001 | Am J Clin Nutr2001，74，： | 1 |
| 16 | Results and follow-up of a phase III randomized study of recombinant human-granulocyte stimulating factor as support for immunosuppressive therapy in patients with severe aplastic anaemia 显示文摘 | Gluckman E Rokicka-Milewska R Hann I | 2002 | Br J Haematol2002，119，4： | 1 |
| 17 | Replication and cytolysis of an E1B-attenuated adenovirus in drug-resistant ovarian tumour cells is associated with reduced apoptosis 显示文摘 | Ganly I Kim YT Hann B | 2001 | Gene Ther2001，8，5： | 1 |
| 18 | The nature of competition in electronic market:an empirical investigation of online travel agent offerings'显示文摘 | Hann I H Hitt LM | 2000 | Rand Journal of Ewnomics2000，141，： | 1 |
| 19 | Determinants of outcome after intensified therapy of childhood lymphoblastic leukemia:results from Medical Research Council United Kingdom acute lymphoblastic leukemia XI protocol显示文摘 | Hann I Vora A Harrison G | 2001 | Br J Haemato12001，113，1： | 1 |
| 20 | Adolescents with acute lymphoblastic leukaemia:outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials显示文摘 | Ramanujachar R Richards S Hann I | 2007 | Pediatr Blood Cancer2007，48，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员