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| 1 | Silicon optical MEMS:optical components and sensors显示文摘 | Kazuhiro Hane | 2002 | 光学精密工程2002，10，6： | 4 |
| 2 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 3 | Water Quality Index Using Modified Random Forest Technique: Assessing Novel Input Features显示文摘Water quality analysis is essential to understand the ecological status of aquatic life.Conventional water quality index(WQI)assessment methods are limited to features such as water acidic or basicity(pH),dissolved oxygen(DO),biological oxygen demand(BOD),chemical oxygen demand(COD),ammoniacal nitrogen(NH3-N),and suspended solids(SS).These features are often insufficient to represent the water quality of a heavy metal–polluted river.Therefore,this paper aims to explore and analyze novel input features in order to formulate an improved WQI.In this work,prospective insights on the feasibility of alternative water quality input variables as new discriminant features are discussed.The new discriminant features are a step toward formulating adaptive water quality parameters according to the land use activities surrounding the river.The results and analysis obtained from this study have proven the possibility of predicting WQI using new input features.This work analyzes 17 new input features,namely conductivity(COND),salinity(SAL),turbidity(TUR),dissolved solids(DS),nitrate(NO3),chloride(Cl),phosphate(PO4),arsenic(As),chromium(Cr),zinc(Zn),calcium(Ca),iron(Fe),potassium(K),magnesium(Mg),sodium(Na),E.coli,and total coliform,in predicting WQI using machine learning techniques.Five regression algorithms-random forest(RF),AdaBoost,support vector regression(SVR),decision tree regression(DTR),and multilayer perception(MLP)-are applied for preliminary model selection.The results show that the RF algorithm exhibits better prediction performance,with R2 of 0.974.Then,this work proposes a modified RF by incorporating the synthetic minority oversampling technique(SMOTE)into the conventional RF method.The proposed modified RF method is shown to achieve 77.68%,74%,69%,and 71%accuracy,precision,recall,and F1-score,respectively.In addition,the sensitivity analysis is included to highlight the importance of the turbidity variable in WQI prediction.The results of sensitivity analysis highlight the importance of certain water quality variables that are not present in the conventional WQI formulation. | Wen Yee Wong Ayman Khallel Ibrahim Al-Ani Khairunnisa Hasikin Anis Salwa Mohd Khairuddin Sarah Abdul Razak Hanee Farzana Hizaddin Mohd Istajib Mokhtar Muhammad Mokhzaini Azizan | 2022 | Computer Modeling in Engineering & Sciences2022，，9： | 2 |
| 4 | CT angiography and perfusion in stroke显示文摘 | Hanes TS | 2002 | Appl Radiol2002，31，6： | 1 |
| 5 | Chitosan nanoparticle as gene therapy vector via gaslrointestinal mueosa administration: results of an in vitro and in vivo study 显示文摘 | SUH J WIRTZ D HANES J | 2007 | Life Sci2007，80，4： | 1 |
| 6 | Drought effect on electrophoretic protein pattern of Anoectochilus for mosa- nus显示文摘 | Pandey D M Wu R Z Hane E J | 2005 | Scientia Horticuhurae2005，168，： | 1 |
| 7 | In vitro selection and evolution of functional proteins by using ribosome display显示文摘 | Hanes J Plückthun A | 1997 | Proc Natl Acad Sci USA1997，94，10： | 1 |
| 8 | Enamel uptake and patient exposure to fluoride:comparison of APF gal and foam显示文摘 | Whitford GM Adair SM Hanes CMM | 1995 | American Academy of Pediatric dentistry1995，17，3： | 1 |
| 9 | Effect of Nionthe ion selectivity of rust layer on low alloy steel显示文摘 | ChenX DongJ HanE H etal | 2007 | Ma terials Letters2007，61，： | 1 |
| 10 | Impact of extreme temperatures on parasitoids in climate change perspective显示文摘 | Hanee T van Baaren J Vemon P | 2007 | Annual Review of Entomology2007，，52： | 1 |
| 11 | Propofol attenuates hydrogen peroxide-induced mechanical and metabolic derangements in the isolated rat hearts显示文摘 | Hane A | 1996 | Anesthesiology1996，84，1： | 1 |
| 12 | Sequencing inputs to multi-commodity pipelines显示文摘 | Christopher A Hane | 1995 | Annals of Operation Research1995，57，4： | 1 |
| 13 | In vitro selection and evolution of functional proteins by using ribosome display 显示文摘 | Hanes J Pluckthun A | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 14 | Fabian TCTetracy-clines of treating mulutidrug-resistant Acinetobacter baumanniiventilator-associated pneumonia 显示文摘 | Wood GC Hanes SD Boucher BA ^ al | 2003 | Intensive Care Med2003，29，11： | 1 |
| 15 | Oral drug delivery with polymeric nanoparticles : the gastrointestinal mucus barriers 显示文摘 | Ensign LM Cone R Hanes J | 2012 | Adv Drug Deliv Rev2012，64，6： | 1 |
| 16 | In vitro selection and evolution of functional proteins by using ribosome display显示文摘 | Plückthun A | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 17 | Irreversible membrane fouling during ultrafiltration of surface water显示文摘 | Katsuki Kimura Yasuhi Hane Yoshimasa Watanabe | 2004 | Water Research2004，38，14： | 1 |
| 18 | Ribosome display:an in vitro method for election and evolution of antibodies from libraries 显示文摘 | Schaffitzel C Hanes J Jermutus L | 1999 | J Immunol Methods1999，231，： | 1 |
| 19 | The tissue renin-angiotensin-aldosterone system in diabetes mellitus显示文摘 | Hanes D S Nahar A Weir M R | 2004 | Cruu Hypertens Rep2004，6，2： | 1 |
| 20 | Urban planning as an urban problem: The reconstruction of Tokyo after the Great Kanto Earthquake显示文摘 | Hanes J E | 2000 | Seisaku Kagaku2000，7，3： | 1 |
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