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| 1 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 2 | Strength of preference in the graph model for conflict resolution 显示文摘 | Hamouda L Kilgour D M Hipel K W | 2004 | Group Decision and Negotiation2004，13，5： | 1 |
| 3 | Strength of preference in graph models for multiple-decision-makerconflicts 显示文摘 | Hamouda L Kilgour D M Hipel K W | 2006 | Applied Mathematics and Computation2006，179，1： | 1 |
| 4 | Strength of preference in graph models for multiple-decision-maker conflicts显示文摘 | HAMOUDA L KILGOUR D M HIPEL K W | 2006 | Applied Mathematics and Computation2006，179，1： | 1 |
| 5 | The first carbonate field application of a new organically cross-linked water shut-off polymer system显示文摘 | Hardy B R Botermans H W Hamouda A | 1999 | SPE1999，50，738： | 1 |
| 6 | Modulation Recognition for MIMO Relaying Broadcast Channels with Direct Link显示文摘 | Ben C W Dayoub I Hamouda W | 2014 | IEEE Wireless Communications Letters2014，3，1： | 1 |
| 7 | Glucose challenge stimulates reactive oxygen species (ROS) generation by leucoeytes显示文摘 | Mohanty P Hamouda W Garg R | 2000 | J Clin Endocrinol Metab2000，85，8： | 1 |
| 8 | Effect of triiodothyronine on reactive oxygen species generation by leukocytes,indices of oxidative damage,and antioxidant reserve显示文摘 | Magsino CHJR Hamouda W Ghanim H | 2000 | Metabolism2000，49，6： | 1 |
| 9 | Cross-layer Antenna Selection and Channel Allocation for MIMO Cognitive Radios显示文摘 | Ghosh A Hamouda W | 2011 | IEEE Transactions on Wireless Communications2011，10，11： | 1 |
| 10 | Effect of triiodothyronine on reactive oxygen species generation by leukocytes, indices of oxidative damage, and antioxidant reserve显示文摘 | Magsino CH Jr Hamouda W Ghanim H | 2000 | Metabolism2000，49，6： | 1 |
| 11 | Inhibitory effect of a two day fast on reactive oxygen species generation by leucocytes and plasma ortho-tyrosine and metatyrosine concentrations显示文摘 | Dandona P Mohanty P Hamouda W | 2001 | J Clin Endocrinol Nutr2001，86，： | 1 |
| 12 | Auto- matic Modulation Recognition Using Wavelet Transform and Neural Networks in Wireless Systems 显示文摘 | HASSAN K DAYOUB I HAMOUDA W | 2010 | EUR- ASIP Journal on Advances in Signal Processing2010，，42： | 1 |
| 13 | The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes,lipid peroxidation,and protein carbonylation显示文摘 | Dandona P Mohanty P Ghanim H Aljada A Browne R Hamouda W | 2001 | J Clin Endocrinol Metab2001，86，1： | 1 |
| 14 | An Efficient Medium Access Control Protocol for Mobile Ad hoc Networks Using Antenna Arrays显示文摘 | Pan Yuxin Hamouda W Elhakeem A | 2007 | Canadian Journal of Electrical and Computer Engineering2007，32，1： | 1 |
| 15 | Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes显示文摘 | Mohanty P Hamouda W Garg R | 2000 | J Clin Endocrinol Metab2000，85，8： | 1 |
| 16 | Insulin inhibits intranuclear nuclear factor kappa B and stimulates I kappa B in mononuclear cells in obese subjects:evidence for an anti-inflammation effect?显示文摘 | Dandona P Aljada A Mohanty P Ghanim H Hamouda W Assian E | 2001 | J Clin Endocrinol Metab2001，86，7： | 1 |
| 17 | Inhibitory effect of a two day fast on reactive oxygen species generation by leucocytes and plasma ortho - tyrosine and metatyrosine concentrations显示文摘 | Dandona P Mohanty P Hamouda W | 2001 | J Clin Endocrind Metab2001，86，： | 1 |
| 18 | Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes显示文摘 | Mohanty P Hamouda W Garg R | 2000 | J Clin Endocrinol Metab2000，85，8： | 1 |
| 19 | Effect of triiodothyromine on reactive oxygen species genera- tion by leukocytes of oxidative damage, and antioxi- dant reserve 显示文摘 | Magsino CH Jr Hamouda W Ghanim H | 2000 | Metabolism2000，49，： | 1 |
| 20 | Inhibitory effect of a two day fast on reactive oxygen species generation by leucocytes and plasma ortho - tyrosine and metatyrosine concentrations 显示文摘 | Dandona P Mohanty P Hamouda W | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
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