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| 1 | 低社会经济地位与美国成年人早发冠状动脉粥样硬化性心脏病的关系显示文摘低社会经济地位(socioeconomic status,SES)的个体承担着不成比例的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)负担。在美国低收入地区,CHD仍然是死亡的主要原因。该研究旨在评估美国低SES个体的过量CHD负担,以及传统风险因素和与低SES相关因素影响所占的比例。 | Hamad R Penko J Kazi DS Coxson P Guzman D Pengxiao C.Wei Mason A Wang EA Goldman L Fiscella K Bibbins-Domingo K 周卫(译) 刘莉(审校) | 2020 | 中华高血压杂志2020，28，7： | 7 |
| 2 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 3 | Kinetic Insights into the Role of the Solvent in the PolymorpHism of 5-Fluorou-racil from Molecular Dynamics Simulations显示文摘 | Hamad S Moon C Catlow C R A | 2006 | J Phys Chem B2006，110，7： | 1 |
| 4 | Structure and stability of small TiO2 nanoparticles显示文摘 | Hamad S Catlow C R A Woodley S M | 2005 | J Phys Chem B2005，109，15： | 1 |
| 5 | A new multivariate mapping method for studying species assemblages and their habitats: example using bottom trawl surveys in the Bay of Biscay(France) 显示文摘 | Souissi S Ibanez F Hamadou R B | 2001 | Sarsia2001，86，： | 1 |
| 6 | Titanium plates support for chest wall reconstruction with Gore-Tex dual mesh after sternochondral resection显示文摘 | Hamad AM Marulli G Bulf R | 2009 | Eur J Cardiothorac Surg2009，36，4： | 1 |
| 7 | Behavior of concrete block masonry under axial compression显示文摘 | DRYSDALE R G HAMAD A A | 1979 | ACI Structural Journal1979，76，3： | 1 |
| 8 | Increased thrombin generation in women with a history of preeclampsia 显示文摘 | Rafik Hamad R Curvers J Berntorp E | 2009 | Thromb Res2009，123，4： | 1 |
| 9 | Synchronous Multiple Ossifying Tumors of the Digits: Metastatic Cardiac Myxoma显示文摘 | Hamade Y Moriuchi R Miyauchi T | 2016 | Circulation2016，133，6： | 1 |
| 10 | A pro- spective, randomized study of the effects of continuous ultrafiltra- tion in hepatic patients after cardiac valve surgery显示文摘 | EI TAHAN M R HAMAD R A GHONEIMY Y F | 2010 | J Cardio- thorac Vasc Anesth2010，24，1： | 1 |
| 11 | Using Ge/Si ratios to decouple iron and silica fluxes in Precambrian banded iron formations显示文摘 | Hamade T Konhauser K O Raiswell R | 2003 | Geology2003，31，1： | 1 |
| 12 | Risk factors for persistent tzopho-blastic activity after surgery for ectopic pregnancy显示文摘 | Nathorst-Boos J Rafik Hamad R | 2004 | Acta Obstet Gynecel Stand2004，83，5： | 1 |
| 13 | Creep life prediction of service-exposed turbine blades显示文摘 | MARAHLEH G KHEDER A R I HAMAD H F | 2006 | Materials Science and Engineering2006，，： | 1 |
| 14 | Model for Facilities or Vendors Location in A Global Scale Considering Several Echelons in the Chain 显示文摘 | HAMAD R GUALDA N D F | 2008 | Network Spatial Economies2008，8，23： | 1 |
| 15 | Using Ge/Si ratios to decouple iron and silica fluxes in Precambrian banded iron formations显示文摘 | Hamade T Konhauser K O Raiswell R Goldsmith S and Morris R C | | 0，，： | 1 |
| 16 | Different secretion patterns of matrix metalloproteinases and IL-8 and effect of corticotropin-releasing hormone in preterm and term cervical fibroblasts显示文摘 | Dubicke A Akerud A Sennstrom M Hamad R R Bystrom B Malmstrom A | 2008 | Mol Hum Reprod2008，14，： | 1 |
| 17 | Risk factors for persistent显示文摘 | Nathorst boos J Rarik hamad R | 2001 | J Obstet Gynecol2001，10，6： | 1 |
| 18 | Assessing the effects of shear, compression, and peel on the cathodic degradation of elastomer - to - metal adhesive bonds显示文摘 | Hamade R F Dillard D A | 2005 | International Journal of Adhesion and Adhesives2005，25，： | 1 |
| 19 | Creep life prediction of service-exposed turbine blades 显示文摘 | Marahleh G Kheder A R I Hamad H F | 2006 | Materials Science and Engineering A2006，433，： | 1 |
| 20 | Using Ge/Si ratios to decouple iron and silica fluxes in Precambrian banded iron formations显示文摘 | Hamade T Konhauser K O Raiswell R | 2003 | Geology2003，31，： | 1 |
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