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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Complete mappings of finite groups 显示文摘 | Hall M Paige L J | 1957 | Pacific Journal of Mathematics1957，5，： | 2 |
| 3 | Complete mappings of finite groups显示文摘 | HALL M PAIGE L J | 1957 | Pacific Journal of Mathematics1957，5，： | 1 |
| 4 | Laboranory mutants of OXA-10 beta- lactamase giving ceftazidime resistance in Pseudomonas aeruginosa 显示文摘 | Danel F Hall L M Livermore D M | 1999 | J Antimicrob Chemother1999，43，3： | 1 |
| 5 | Role of sediment composition in tracemetal distribution in lake sediments显示文摘 | Blilali L El Rasmussen P E Hall G E M | 2002 | Applied Geochemistry2002，17，： | 1 |
| 6 | Freezing point de- pression of NaC1-KCI-H20 solutions 显示文摘 | Hall D L Sterner S M and Bodner R J | 1988 | Economic Geology1988，100，5： | 1 |
| 7 | Effects of seawater ozonation on biofilm development in aquaculture tanks显示文摘 | Wietz M Hall M R Hj L | 2009 | Systematic and Applied Microbiology2009，32，4： | 1 |
| 8 | Carbon and nitrogen analysis of soil fractions using near infrared reflectance spectroscopy显示文摘 | Morra M J Hall M H Freeborn L L | 1991 | Soil Science Society of American Journal1991，，55： | 1 |
| 9 | Throwing the mountains into the lakes:On the perils of nomothetic conceptions of the exercise-affect relationship显示文摘 | Van Landuyt L M Ekkekakis P Hall | 2000 | Journal of Sport and Exercise Psychology2000，22，： | 1 |
| 10 | New mobile gene cassettes containing an aminogly coside resistance gene,aaeA 7,and a chloramphenico resistance gene, catB, in an integron in pBWH301 显示文摘 | Bunny K L Hall R M Stokes H W | 1995 | Antimicrob A gents Chem other1995，39，： | 1 |
| 11 | Mechanism of resistance to chlorotoluron in two biotypes of the grass weed Alopecurus myosuroides显示文摘 | Hall L M | 1995 | Pestic Biochem Physiol1995，53，3： | 1 |
| 12 | Stereophonic acoustic echo cancellation-an overview of the fundamental problem显示文摘 | M Mohan Sondhi Dennis R Morgan Joseph L Hall | 1995 | IEEE Signal Processing Letters1995，2，8： | 1 |
| 13 | Freezing point depression of NaCl-KCl-H2O solutions显示文摘 | Hall D L Sterner S M Bodnar R J | 1988 | Economic Geology1988，83，： | 1 |
| 14 | Freezing point depression of NaC1-KCI-HzO solutions显示文摘 | HALL D L STERNER S M BODNAR R J | 1988 | Economic Geology1988，83，： | 1 |
| 15 | The use of partial extraction geochemistry for copper esploration in northern Chile显示文摘 | Kelley D L Hall G E M Graham Closs L | 2003 | Geochemistry: Exploration Environment Analysis2003，3，1： | 1 |
| 16 | Sequence and spacing of TATA box elements are critical for accurate initiation from the β-phaseolin promoter显示文摘 | GRACE M L CHANDRASEKHARAN M B HALL T C CROWE A J | 2004 | Biological Chemistry2004，279，： | 1 |
| 17 | Development and validation of a measure of emotional intelligence显示文摘 | SCHUTTE N S MALOUFF J M HALL L E | 1998 | Personality and Individual Differences1998，，2： | 1 |
| 18 | Health-related quality of life measurement in women with polycystic ovary syndrome:a systematic review显示文摘 | Jones G L Hall J M Balen A H | 2008 | Hum Reprod Update2008，14，1： | 1 |
| 19 | Short communication 40Ar/39Ar ages of adular- ia from the Golden Cross, Neavesville and Komata epithermal de- posits, Hauraki Goldfield, New Zealand显示文摘 | Mauk J L Hall C M | 2004 | New Zealand Journal of Geology & Geophysics2004，47，： | 1 |
| 20 | Evolution of a TRIMS-CypA splice isoform in old world monkeys 显示文摘 | Newman R M Hall L Kirmaier A | 2008 | Plos Pathogens2008，4，10： | 1 |
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