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| 1 | Constitutive androstane receptor agonist, TCPOBOP,attenuates steatohepatitis in the methionine choline-deficientdiet-fed mouse显示文摘AIM:To ascertain whether constitutive androstane receptor(CAR)activation by 1,4-bis-2-(3,5,-dichloropyridyloxy)benzene(TCPOBOP)modulates steatohepatitis in the methionine choline-deficient(MCD)diet-fed animal.METHODS:C57/BL6 wild-type mice were fed the MCD or standard diet for 2 wk and were treated with either the CAR agonist,TCPOBOP,or the CAR inverse agonist,androstanol.RESULTS:Expression of CYP2B10 and CYP3A11,known CAR target genes,increased 30-fold and 45-fold,respectively,in TCPOBOP-treated mice fed the MCD diet.TCPOBOP treatment reduced hepatic steatosis(44.6 ± 5.4% vs 30.4 ± 4.5%,P < 0.05)and serum triglyceride levels(48 ± 8 vs 20 ± 1 mg/dL,P < 0.05)in MCD diet-fed mice as compared with the standard diet-fed mice.This reduction in hepatic steatosis was accompanied by an increase in enzymes involved in fatty acid microsomal ω-oxidation and peroxisomal β-oxidation,namely CYP4A10,LPBE,and 3-ketoacyl-CoA thiolase.The reduction in steatosis was also accompanied by a reduction in liver cell apoptosis and inflammation.In contrast,androstanol was without effect on any of the above parameters.CONCLUSION:CAR activation stimulates induction of genes involved in fatty acid oxidation,and ameliorates hepatic steatosis,apoptosis and inflammation. | Edwina S Baskin-Bey Akira Anan Hajime Isomoto Steven F Bronk Gregory J Gores | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 2 | The effect of acid treatment of coal on H2S evolution during pyrolysis in hydrogen显示文摘 | YASUSHI S MITSUNORI M HAJIME Y OSAMU Y MITSUO K MAMORU K | 1998 | Fuel1998，77，910： | 1 |
| 3 | Cloning,sequence analysisand expression in Escherichia coli if the gene encoding a uricasefrom the yeast-like symbionts of brown planthoppers,Nilapa-rvata lugens显示文摘 | Yuichi H Tetsuhiko S Hajime I | 2000 | Insect Biochemistry and Molecular Biology2000，30，： | 1 |
| 4 | Enzymatic synthesis of carbohydrate esters of fatty acid(I) esterification of sucrose, glucose,fructose and sorbitol显示文摘 | Hajime S Tsuyoshi U Toshiyuki N | 1984 | Journal of the American Oil Chemists Society1984，61，11： | 1 |
| 5 | Reduction of cerebellar glucose metabolism in advanced Alzheimer's disease 显示文摘 | Kazunari I Masahiro S Hajime K | 1997 | J Nucl Med1997，38，： | 1 |
| 6 | Infrared carbonyl absorptions and conformations of methyl-substituted acetones显示文摘 | Minoru H Takeaki H and Hajime S | 1967 | Bulletin of the Chemical Society of Japhan1967，40，10： | 1 |
| 7 | Transition metal-aluminate catalysts for NO reduction by C3H6显示文摘 | Ken-ichi S Hajime M Atsushe S | 1998 | Appl Catal B : Environment1998，18，12： | 1 |
| 8 | Molecular cloning of β-galactosidase from japanese pear (Pyrus pyrifolia) and its gene expression with fruit ripening显示文摘 | TATEISHI A HIROAKI I HAJIME S | 2001 | Plant and Cell Physiology2001，42，5： | 1 |
| 9 | A long-term culture of human hepatocytes which shows a high growth potential and express their differentiated phenotype 显示文摘 | Hino H Tateno C Hajime S | 1999 | Biochem Biophys Res Com1999，256，： | 1 |
| 10 | Preparation and characteristics of fine hollow carbon particles显示文摘 | HISASHI T TAKHIRO S HAJIME Y | 1996 | Journal of Colloid and Interface Science1996，177，2： | 1 |
| 11 | The Swift Ultra-Violet/Optical Telescope显示文摘 | Peter W. A. Roming Thomas E. Kennedy Keith O. Mason John A. Nousek Lindy Ahr Richard E. Bingham Patrick S. Broos Mary J. Carter Barry K. Hancock Howard E. Huckle S D. Hunsberger Hajime Kawakami Ronnie Killough T Scott Koch Michael K. Mclelland Kelly Smith | 2005 | Space Science Reviews (-)2005，，3： | 1 |
| 12 | Improvement of the new no detection method using laser-induced two-photon ionization with a tof mass spectrometer显示文摘 | Lee S H Yoshizumi K Hajime A | 2000 | Environ Sci Technol2000，34，20： | 1 |
| 13 | Nitrogen removal from wastewater using simultaneous nitrate reduction and anaerobic ammonium oxidation in single reactor显示文摘 | Tatsuo S Kazuichi I Hajime I | 2006 | J Biosci Bioengin2006，102，4： | 1 |
| 14 | Resuscitation and preservation of agonally arrested hearts for transplantation显示文摘 | RYOTA S HAJIME H HIKARU M | 1989 | Transplant Proc1989，21，： | 1 |
| 15 | Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice显示文摘 | HIROAKI O HAJIME N YASUYUKI S | 2005 | Journal of Hepatology2005，42，： | 1 |
| 16 | Expression analysis of genes encoding plasma membrane aquaporins during seed and fruit development in tomato显示文摘 | Hajime S Takehiro S Ichiro T | 2006 | Plant Science2006，171，2： | 1 |
| 17 | Increased expression of trk proto-oncogene by γ-interferon in human neuroblastoma cell lines显示文摘 | TOHRU S HAJIME H | 1994 | J Cancer Res1994，85，2： | 1 |
| 18 | Nitrogen removal from wastewater using simultaneous nitrate reduction and anaerobic ammonium oxidation in single reactor显示文摘 | TATSUO S KAZUICHI I HAJIME I | 2006 | Journal of Bioscience and Bioengineering2006，102，4： | 1 |
| 19 | Interaction between β-amyloid protein and heparan sulfate proteoglycans from the cerebral capillary basement membrane in Alzheimer's disease显示文摘 | Hajime S Mohammad G Shigeru S | 2009 | J Clin Neurosci2009，16，： | 1 |
| 20 | Measuring the impact of large-scale transportation projects on land price using spatial statistical models显示文摘 | Morito T Hajime S | 2008 | Papers in Regional Science2008，87，3： | 1 |
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