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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | The effect of acid treatment of coal on H2S evolution during pyrolysis in hydrogen显示文摘 | YASUSHI S MITSUNORI M HAJIME Y OSAMU Y MITSUO K MAMORU K | 1998 | Fuel1998，77，910： | 1 |
| 3 | Ac impedance analysis of bifunctinal air electrodes for metal-air batteries 显示文摘 | HAJIME A STEFAN M OTTO H | 2000 | J Electrochem Soc2000，147，： | 1 |
| 4 | Long-Term Beneficial Effect of Late Reperfusion for Acute Anterior Myocardial Infarction With Percutaneous Transluminal Coronary Angioplasty显示文摘 | Hajime H Masayuki T Kazuo M | 1998 | Circulatiort1998，98，22： | 1 |
| 5 | Management of complications associated with endoscopic submucosal dissection/endoscopic mucosal resection for esophageal cancer显示文摘 | Hajime I Naoyuki Y Hitomi M | 2013 | Digestive Endoscopy2013，25，1： | 1 |
| 6 | Numerical analysis of effects of tidal variations on storm surges and waves显示文摘 | SOOY K TOMOHIRO Y HAJIME M | 2008 | Applied Ocean Research2008，30，4： | 1 |
| 7 | Cultivation line and fruitripening discriminations of Shiikuwasha peel oils using aroma compositional electronic nose, and antioxidant analyses 显示文摘 | Yonathan A Goki M Hajime T | 2015 | Food Research International2015，67，： | 1 |
| 8 | Development of a quantitative realtime polymerase chain reaction targeted to the toxR for detection of Vibrio vulniticus显示文摘 | Hajime T Yukiko H Jiro M | | J Microbiol Methods0，61，1： | 1 |
| 9 | Sampling and detectionof legionella pneumophila aerosol generated from an industrialcooling tower显示文摘 | Sumiyo I Hiroshi M Hajime H | 2001 | The Annals of Occupational Hygiene2001，45，6： | 1 |
| 10 | Induction of true precocious puberty by neonatal treatment with danazol in female rats显示文摘 | Hajime M Mikihik Hajime M Mikihiko T | 1993 | Neuroscience Lett1993，157，： | 1 |
| 11 | Damping properties of thermoplastic-elastomer interleaved carbon fiber-rcinforced epoxy composites显示文摘 | Hajime K Manabu K Satoshi M | 2004 | Comp Sci Techn2004，，64： | 1 |
| 12 | Long-term outcome of primary percutaneous translurninal coronary angioplasty for low-risk acute myocardial infarction in patients older than 80 years: A single-center,open,randomized trial显示文摘 | Kazuo M Hajime H Masayuki T | 2002 | Am Heart J2002，143，： | 1 |
| 13 | Transition metal-aluminate catalysts for NO reduction by C3H6显示文摘 | Ken-ichi S Hajime M Atsushe S | 1998 | Appl Catal B : Environment1998，18，12： | 1 |
| 14 | The effects of angiotensin metabolites on the regulation of coagulation and fibrinolysis in cultured rat endothelial cells 显示文摘 | HIROMI N HAJIME T HARUCHIKA M | 1999 | Thromb Haemost1999，82，5： | 1 |
| 15 | MiRNA - 205 modulates cel- lular invasion and migration via regulating zinc finger E - box binding homeobox 2 expression in esophageal squamous cell carcinoma cells 显示文摘 | Kayoko M Hajime I Naoyuki Y | 2011 | Journal of Translational Medicine2011，9，： | 1 |
| 16 | pH dependence of inclusion complexation between cationic poly( -lysine) and a-cyclodextrin 显示文摘 | Kang M H Hajime T Tcoru O | 2002 | Macromolecules2002，35，9： | 1 |
| 17 | Resuscitation and preservation of agonally arrested hearts for transplantation显示文摘 | RYOTA S HAJIME H HIKARU M | 1989 | Transplant Proc1989，21，： | 1 |
| 18 | Function in ovarian tumors: direct and indirect findings at MR imaging显示文摘 | Yumiko O Tanaka M D Hajime M | 2004 | Radio Graphics2004，24，2： | 1 |
| 19 | Study of arsenic trioxide induced vascular shutdown and enthancement with radiation in solid tumor显示文摘 | Hajime M Robert JG Brent WW | 2004 | Radiat Med2004，22，4： | 1 |
| 20 | Enhanced expression of genes for ACC synthase, ACC oxidase, and NAC protein during high-temperature-induced necrosis of young inflorescenees of Cymbidium 显示文摘 | Satoru M Ryuya H Hajime O | 2006 | Physiologia Plantarum2006，128，： | 1 |
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