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| 1 | Hepatocellular injury and the mortality risk among patients with COVID-19: A retrospective cohort study显示文摘BACKGROUND Clearly,infection with severe acute respiratory syndrome coronavirus 2 is not limited to the lung but also affects other organs.We need predictive models to determine patients’prognoses and to improve health care resource allocation during the coronavirus disease 2019(COVID-19)pandemic.While treating COVID-19,we observed differential outcome prediction weights for markers of hepatocellular injury among hospitalized patients.AIM To investigate the association between hepatocellular injury and all-cause inhospital mortality among patients with COVID-19.METHODS This multicentre study employed a retrospective cohort design.All adult patients admitted to Al-Azhar University Hospital,Assiut,Egypt and Abo Teeg General Hospital,Assiut,Egypt with confirmed COVID-19 from June 1,2020,to July 30,2020 were eligible.We categorized our cohort into three groups of(1)patients with COVID-19 presenting normal aminotransferase levels;(2)patients with COVID-19 presenting one-fold higher aminotransferase levels;and(3)patients with COVID-19 presenting two-fold higher aminotransferase levels.We analysed the association between elevated aminotransferase levels and all-cause in-hospital mortality.The survival analysis was performed using the Kaplan–Meier method and tested by log-rank analysis.RESULTS In total,376 of 419 patients met the inclusion criteria,while 29(8%)patients in our cohort died during the hospital stay.The median age was 40 years(range:28-56 years),and 51%were males(n=194).At admission,54%of the study cohort had liver injury.The pattern of liver injury was hepatocellular injury with an aspartate aminotransferase(AST)predominance.Admission AST levels were independently associated with all-cause in-hospital mortality in the logistic regression analysis.A one-fold increase in serum AST levels among patients with COVID-19 led to an eleven-fold increase in in-hospital mortality(P<0.001).Admission AST levels correlated with C-reactive protein(r=0.2;P<0.003)and serum ferritin(r=0.2;P<0.0002)levels.Admission alanine aminotransferase levels correlated with serum ferritin levels(r=0.1;P<0.04).Serum total bilirubin levels were independently associated with in-hospital mortality in the binary logistic regression analysis after adjusting for age and sex but lost its statistical significance in the fully adjusted model.Serum ferritin levels were significantly associated with in-hospital mortality(P<0.01).The probability of survival was significantly different between the AST groups and showed the following order:a two-fold increase in AST levels>a one-fold increase in in AST levels>normal AST levels(P<0.0001).CONCLUSION Liver injury with an AST-dominant pattern predicts the severity of COVID-19.Elevated serum ferritin levels are associated with fatal outcomes. | Ali Madian Ahmed Eliwa Hytham Abdalla Haitham A Azeem Aly | 2021 | World Journal of Hepatology2021，13，8： | 3 |
| 2 | New methodology for es- timating reliability in transportation networks with degraded link capacities 显示文摘 | HAITHAM A D EMAM B | 2006 | Journal of Intelligent Transportation Systems2006，10，3： | 1 |
| 3 | Acombined traveler behavior and system performancemodel with advanced traveler information systems 显示文摘 | HAITHAM M DEEK A L’KHATTAK AJ etal | 1998 | Transportation Research Record1998，32，7： | 1 |
| 4 | Optimizing thesupply chain of a petrochemical company under uncertain operatingand economic conditions 显示文摘 | Haitham M S L Mohamed A A Imad M A Enzi A F | 2004 | Industrial & Engineering ChemicalResearch2004，43，1： | 1 |
| 5 | Aspartate transferase-to-platelet ratio index-plus: A new simplified model for predicting the risk of mortality among patients with COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has a spectrum of clinical syndromes with serious involvement of the lung and frequent effection of the liver and hemostatic system.Blood biomarkers are affordable,rapid,objective,and useful in the evaluation and prognostication of COVID-19 patients.AIM To investigate the association between aspartate transferase-to-platelet ratio index(APRI)and in-hospital mortality to develop a COVID-19 mortality prediction model.METHODS A multicenter cohort study with a retrospective design was conducted.Medical records of all consecutive adult patients admitted to Al-Azhar University Hospital(Assiut,Egypt)and Chest Hospital(Assiut,Egypt)with confirmed COVID-19 from July 1,2020 to October 1,2020,were retrieved and analyzed.The patient cohort was classified into the following two categories based on the APRI:(1)COVID-19 presenting with APRI≤0.5;and(2)COVID-19 presenting with APRI(>0.5 and≤1.5).The association between APRI and all-cause in-hospital mortality was analyzed,and the new model was developed through logistic regression analyses.RESULTS Of the 353 patients who satisfied the inclusion criteria,10%were admitted to the intensive care unit(n=36)and 7%died during the hospital stay(n=25).The median age was 40 years and 50.7%were male.On admission,49%had aspartate transferase-dominant liver injury.On admission,APRI(>0.5 and≤1.5)was independently associated with all-cause in-hospital mortality in unadjusted regression analysis and after adjustment for age and sex;after stepwise adjustment for several clinically relevant confounders,APRI was still significantly associated with all-cause inhospital mortality.On admission,APRI(>0.5 and≤1.5)increased the odds of mortality by fivetimes(P<0.006).From these results,we developed a new predictive model,the APRI-plus,which includes the four predictors of age,aspartate transferase,platelets,and serum ferritin.Performance for mortality was very good,with an area under the receiver operating curve of 0.90.CONCLUSION APRI-plus is an accurate and simplified prediction model for mortality among patients with COVID-19 and is associated with in-hospital mortality,independent of other relevant predictors. | Ali Madian Ahmed Eliwa Hytham Abdalla Haitham A Azeem Aly | 2022 | World Journal of Gastroenterology2022，28，16： | 1 |
| 6 | A fuzzy heuristic approach for predicting asphaltene precipitation potential 显示文摘 | Haitham M S Lababidi Ali A Garrouch Mohammed A Fahim | 2001 | Energy & Fuels2001，18，1： | 1 |
| 7 | Speed sensorless induction motor drive with predictive current controller 显示文摘 | JAROSLAW G HAITHAM A R | 2013 | IEEE Transactions on In- dustrial Electronics2013，60，2： | 1 |
| 8 | Late endocarditis of Amplatzer atrial septal occluder device in a child显示文摘Bacterial endocarditis following atrial septal defect closure using Amplatzer device in a child is extremely rare. We report a 10-year-old girl who developed late bacterial endocarditis, 6 years after placement of an Amplatzer atrial septal occluder device. Successful explantation of the device and repair of the resultant septal defect was carried out using a homograft patch. The rare occurrence of this entity prompted us to highlight the importance of a closed long-term follow up, review the management and explore preventive strategies for similar patients who have multiple co-morbidities and a cardiac device. A high index of suspicion is warranted particularly in pediatric patients. | Neerod K Jha Laszlo Kiraly John SK Murala Csaba Tamas Haitham Talo Hazem El Badaoui Magdi Tofeig Malaika Mendonca Sameer Sajwani Mary A Thomas Sura Ahmed Al Doory Mohammad D Khan | 2015 | World Journal of Cardiology2015，7，10： | 1 |
| 9 | DNA polymerase beta 显示文摘 | Haitham TI Osama A Samuel H | 2002 | The Int J Bioc & Cell Biology2002，34，： | 1 |
| 10 | Supply chain optimization of petroleum organization under uncertainty in market demands and prices显示文摘 | WAFA B E HAITHAM A O LABABIDI M S | 2008 | European Journal of Operational Research2008，189，3： | 1 |
| 11 | A new stochastic discrete-event micro simulation model for evaluating traffic operations at Electronic Toll Collection plazas 显示文摘 | Al-Deek Haitham M Mohamed Ayman A Malone Linda | 2005 | Journal of Intelligent Transportation Systems2005，，9： | 1 |
| 12 | Analysis of concrete constructionlive loads on newly poured slabs 显示文摘 | Saeed K Haitham A | 1994 | Journal ofstructure engineering1994，，120： | 1 |
| 13 | Survey results for concreteconstruction live loads on newly poured slabs 显示文摘 | Haitham A Saeed K | 1994 | Journal of Structure Engineering1994，，120： | 1 |
| 14 | A simplified analyti- cal method for predicting the critical velocity of vehi- cle impact on steel columnsOriginal Research Article 显示文摘 | HAITHAM A T WANG Y C | 2014 | Journal of Constructional Steel Research2014，92，1： | 1 |
| 15 | Analysis of Segmental Piers Consisted of Concrete Filled FRP Tubes Original Research Article 显示文摘 | Mohamed A E I Gawady Haitham M Dawood | 2012 | Engineering Structures2012，38，1： | 1 |
| 16 | Simplified FE vehicle modelfor assessing the vulnerability of axially compressed steelcolumns against vehicle frontal impact显示文摘 | HAITHAM A T WANg Y C | 2014 | Applied Me-chanics Division2014，237，： | 1 |
| 17 | Space vector PWM technique for a three-to-flve-phase matrix converter显示文摘 | ATIFL AHMED S K HAITHAM A | 2012 | IEEE Transactions on Industry Applications2012，48，2： | 1 |
| 18 | Space-Vector pulsewidth mod-ulation for three-level NPC converter with the neutralpoint voltage control 显示文摘 | ARKADIUSZ LEWICKI ZBIGNIEW KRZEMINSKI HAITHAM A BU RUB | 2011 | IEEE Transactions on In-dustrial Electronics2011，58，11： | 1 |
| 19 | Performance Evaluation of Short-Term Time-Series Traffic Prediction Model显示文摘 | SHERIF I M HAITHAM A M | 2002 | Journal of Transportation Engineering2002，128，6： | 1 |
| 20 | Development of an Expert System for Underbalanced Drilling Using Fuzzy Logic显示文摘 | Ali A G Haitham M S L | 2001 | Journal of Petroleum Science and Engineering2001，31，1： | 1 |
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