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| 1 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 2 | Double-balloon enterosco- py:Indications,diagnostic yield,and complications in a series of 275 patients with suspected small-bowel disease显示文摘 | Heine GD Hadithi M Groenen MJ | 2006 | Endoscopy2006，38，1： | 1 |
| 3 | A prospective study compa- ring video capsule endoscopy with double-balloon enteruscopy in pa- tients with obscure gastrointestinal bleeding 显示文摘 | Hadithi M Heine GD Jacobs MA | 2006 | Am J Gastroenterol2006，101，1： | 1 |
| 4 | A prospective study compa- ring video capsule endoscopy with double-balloon enteroscopy in patients with obscure gastrointestinal bleeding 显示文摘 | Hadithi M Heine GD Jacobs MA | 2006 | Am J Gastroenterol2006，101，1： | 1 |
| 5 | Double-balloon enterosco- py:Indications, diagnostic yield and complications in a series of 275 patients with suspected small- bowel disease 显示文摘 | Hine GD Hadithi M Groenen M J | 2006 | Endoscopy2006，38，1： | 1 |
| 6 | Double-balloon enteroscopy:indications,diagnostic yield,and complications in a series of 275 patients with suspected small-bowel disease显示文摘 | HEINE G D HADITHI M GROENEN M J | 2006 | Endoscopy2006，38，1： | 1 |
| 7 | The fuzzy Kalman filter: State estimation using possibilistic techniques 显示文摘 | Maria F Jimenez A AI Hadithi B M | 2006 | Fuzzy Sets and Systems2006，157，16： | 1 |
| 8 | Protein transduction domains and their utility in gene therapy显示文摘 | Beerens A M J Al Hadithy A F Y Rots M G | 2003 | Curr Gene Ther2003，3，： | 1 |
| 9 | Double-balloon endoscopy: indications, diagnostic yield, and complications in a series of 275 pa- tients with suspected small-bowel disease 显示文摘 | Heine GD Hadithi M Groenen M J | 2006 | Endoscopy2006，38，1： | 1 |
| 10 | A prospective study comparing video capsule endoscopy with doublmballoon enteroscopy in patients with obscure, gastrointestinal bleeding 显示文摘 | HADITHI M HEINE GD JACOBS MA | 2006 | Am J Gastroenterol2006，101，1： | 1 |
| 11 | A prospective study comparing video capsule endoscopy with double-balloon enterascopy in patients with obscure gastrointestinal bleeding 显示文摘 | HADITHI M HEINE G D JACOBS M A | 2006 | Am J Gastroenterol2006，101，1： | 1 |
| 12 | Double-balloon enteroseopy:indications,diagnostic yield,and complications in a series of 275 patients with suspected small-bowel disease显示文摘 | Heine GD Hadithi M Groenen MJ | 2006 | Gastrointest Endose2006，38，： | 1 |
| 13 | A prospective study comparing video capsule endoscopy with double-balloon enteroscopy in patients with obscure gastrointestinal bleeding 显示文摘 | Hadithi M Heine GD Jacobs MA | 2006 | Am J Gastroenterol2006，101，1： | 1 |
| 14 | Association betweenheterophil/lymphocyte ratio,a marker of resistance′to stress,andsome production and fitness traits in chickens显示文摘 | Murrani W K Rawi A J Hadithi M F | 2006 | Brit Poult Sci2006，47，： | 1 |
| 15 | A Prospective study comparing video capsule endoscopy with double balloon enteroscopy in patients with obscure gastrointestinal bleeding显示文摘 | Hadithi M Heine GD Jacobs MA | 2006 | Am J Gastroenterol2006，101，1： | 1 |
| 16 | A prospective study eomparing video capsule endoscopy with double-bal- loon enteroscopy in patients with obscure gastrointestinal bleeding显示文摘 | Hadithi M Heine GD Jacobs MA | 2006 | Am J Gastroenterol2006，101，1： | 1 |
| 17 | Double-balloon enteroscopy:indication,diagnostic yield,and complication in a series of 275 patients with suspected small-bowel disease显示文摘 | Heine CD Hadithi M Groenen M J | 2006 | Gastrointest Endosc2006，38，： | 1 |
| 18 | Double-balloon enteroscopy: indications, diagnostic yield, and complications in a series of 275 patients with suspected smallbowel disease显示文摘 | Heine GD Hadithi M Groenen MJ | 2006 | Gastrointest Endosc2006，38，1： | 1 |
| 19 | Double-balloon enteroscopy: Indications, diagnostic yield and complicationsin a series of 275 patients with suspected small-bowel disease 显示文摘 | HINE GD HADITHI M GROENEN MJ | 2006 | Endoscopy2006，38，1： | 1 |
| 20 | A prospective study comparing video capsule endoscopy with double-balloon enteroscopy in patients with obscure gastrointestinal bleeding显示文摘 | Hadithi M Heine GD Jacobs MA | 2006 | Am J Gastroenterol2006，101，1： | 1 |
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