|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | H pylori infection causes chronic pancreatitis in Mongolian gerbils显示文摘AIM: To investigate whether chronic H pylori infection has the potential to induce pancreatitis in the Mongolian gerbil model, and whether it is dependent on an intact type Ⅳ secretion system. METHODS: Mongolian gerbils were infected with wild type (WT) H pylori typeⅠstrain B128 or its isogenic mutant B128 ?cagY (defective type Ⅳ secretion). After seven months of infection, H pylori was reisolated from antrum and corpus and H pylori DNA was analyzed by semi- nested polymerase chain reaction (PCR). Inflammation and histological changes were documented in the gastric antrum, corpus, and pancreas by immunohistochemistry. Cytokine mRNA, gastric pH, plasma gastrin, amylase, lipase, and glucose levels were determined. RESULTS: The H pylori infection rate was 95%. Eight infected animals, but none of the uninfected group, developed transmural inflammation and chronic pancreatitis. Extensive interstitial fibrosis and inflammation of the pancreatic lobe adjacent to the antrum was confirmed by trichrome stain, and immuno- histochemically. Pro-inflammatory cytokine mRNA was significantly increased in the antral mucosa of all infected gerbils. In the corpus, only cytokine levels of WT-infected animals and those developing transmural inflammation and pancreatitis were significantly increased. Levels of lipase, but not glucose or amylase levels, were significantly reduced in the pancreatitis group. H pylori DNA was detected in infected antral and corpus tissue,but not in the pancreas. CONCLUSION: H pylori infection is able to induce chronic pancreatitis in Mongolian gerbils independently of the type Ⅳ secretion system, probably by an indirect mechanism associated with a penetrating ulcer. | Gabriele Rieder Arno Karnholz Mechthild Stoeckelhuber Juanita L Merchant Rainer Haas | 2007 | World Journal of Gastroenterology2007，13，29： | 10 |
| 2 | Expression of tissue factor in pancreatic adenocarcinoma is associated with activation of coagulation显示文摘瞄准:在 thromboembolism 的开发在胰腺的癌症和它的角色学习织物因素(TF ) 的表示。方法:TF 表示被北污点和间接免疫荧光在八根人的胰腺的癌房间线学习。或者拼接的 TF (asTF ) 的表示被 RT-PCR 估计。另外, TF 表示被免疫荧光与胰腺的腺癌(PCa ) 在 19 个病人的胰腺的纸巾决定,有慢性胰炎(CP ) 的 9 个病人和 20 正常控制。血浆样品(30 PCa 病人, 13 CP 病人和 20 控制) 为可溶的 TF 层次和凝结激活标记被调查[thrombin-antithrombin III 建筑群(梭织) ,凝血素碎片 1 + 2 (F1 + 2 )] 。结果:所有胰腺的癌房间线表示了 TF (8/8 ) ,他们中的大多数表示了 asTF (6/8 ) 。在蛋白质水平的 TF 表示没与癌房间线的区别相关。几乎,二件胰腺的癌症组织样品染色了为 TF (17/19 ) 积极。在 CP 的所有样品,弱染色被限制为胰腺的管房间,而一些仅仅内皮下房间在正常控制的 9/20 是积极的。TF 并且在 PCa 病人梭织层次而 2 铺平的提高的 F1 + 没与控制相比到达统计意义,显著地与控制相比被提高。在病人们梭织的 CP 和 F1 + , 2 个层次证明了显著地与控制相比被提高,尽管梭织举起少些比在 PCa 病人被读。结论:我们结束那除了起来房间膜上的 TF 的调整表示,可溶的 TF 可能在胰腺的癌症贡献凝结系统的激活。 | Stephan L Haas Ralf Jesnowski Michael Steiner Frank Hummel Jrg Ringel Christine Burstein Horst Nizze Stefan Liebe J Matthias Lhr | 2006 | World Journal of Gastroenterology2006，12，30： | 9 |
| 3 | Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ. | Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 4 | Transforming heterogeneous data with database middleware: Beyond integration显示文摘 | Haas L | 1999 | IEEE Data Engg Bulletin1999，22，1： | 3 |
| 5 | Can a polymorphism in the thalassemia gene and a heterozygote CFTR mutation cause acute pancreatitis?显示文摘The case of a 32-year-old black woman of African descent who suffered from repeated episodes of acute pancreatitis, initially triggered when flying on airplanes, is reported. She did not drink alcohol or smoke. Genetic analysis was negative for cationic trypsinogen, serine protease inhibitor Kazal type 1 and chymotrypsin C. However, hemoglobin F was elevated. Sequencing of the thalassemia gene revealed a novel alteration in the 5' region indicative of a functional abnormality of the molecule. Sequencing the cystic fibrosis transmembrane conductance regulator(CFTR) gene revealed a heterozygote sequence variant. The combination of a hemoglobin gene mutation known for thalassemia in conjunction with the hitherto undescribed CFTR mutation is suggested to pave the road for initial and repetitive pancreatitis attacks. This will be discussed. | J-Matthias L?hr Stephan Haas | 2014 | World Journal of Clinical Cases2014，2，3： | 2 |
| 6 | Tumor Marker Evolution: Comparison with Imaging for Assessment of Response to Chemotherapy in Patients with Colorectal Liver Metastases显示文摘 | Robbert J. Haas Dennis A. Wicherts Eduardo Flores Michel Ducreux Francis Lévi Bernard Paule Daniel Azoulay Denis Castaing Antoinette Lemoine René Adam | 2010 | Annals of Surgical Oncology2010，，4： | 2 |
| 7 | Securing ad hoc networks显示文摘 | L Zhou Z J Haas | 1999 | IEEE Network Magazine Special Issue on Network Security1999，13，6： | 1 |
| 8 | I, 25-Dihydroxyvitarnin D3 decreases podocyte loss and podocyte hypertrophy in the subtotaUy nephrectomized rat 显示文摘 | Kuhimann A Haas S Gross L | 2004 | Am J Physiol Renal Physiol2004，286，3： | 1 |
| 9 | Ligand binding to integrins显示文摘 | Plow EF Haas TA Zhang L | 2000 | J Biol Chem2000，275，21： | 1 |
| 10 | Primary and secondary structure of a new viroid 'species' (CbVdl) present in the Coleus blumei cultivar 'Bienvenue 显示文摘 | SPIEKER R L HAAS B CHARNG Y C | 1990 | Nucleic Acids Res1990，18，13： | 1 |
| 11 | Securing ad hoc networks显示文摘 | Zhou L Haas Z J | 1999 | IEEE Network1999，13，6： | 1 |
| 12 | A randomized clinical trial of inpatient family intervention,lII:effects at 6-month and 18 -month follow-ups 显示文摘 | Spencer J H Glick I D Haas G L | 1988 | Am J Psychiatry1988，145，9： | 1 |
| 13 | Simulated rarefied aerodynamics of the Magellan spacecraft during aerobraking显示文摘 | Haas Brian L Schmitt Durwin A | 1994 | Journal of Spacecraft and Rockets1994，31，5： | 1 |
| 14 | Securing ad hoc networks显示文摘 | Zhou L Haas Z | 1999 | IEEE Network1999，13，6： | 1 |
| 15 | Ligand binding to integrins显示文摘 | Plow EF Haas TA Zhang L | 2000 | J Biol Chem2000，275，21： | 1 |
| 16 | Rhetorical reading strategies and the construction of meaning 显示文摘 | HAAS C FLOWER L | 1988 | College Composition and Com- munication1988，39，2： | 1 |
| 17 | Superconduc- tively Levitated Transport System-the SupraTrans Pro- ject 显示文摘 | Schultz L Haas O de Verges P | 2005 | IEEE Transaction on Applied Superconductiv- ity2005，15，2： | 1 |
| 18 | Predominance of a single genotype of Mycobacterium tuberculosis in countries of east Asia显示文摘 | Van Soolingen D Oian L De Haas P | 1995 | J Clin Microbiol1995，33，12： | 1 |
| 19 | Rare earth elements in hydrothermal systems: Estimates of standard partial mold thermodynamic properties of aqueous complexes of the rare earth elements at high pressures and temperatures 显示文摘 | Haas J R Shock E L Sassani D C | 1995 | Geochimica et Cosmochimica Acta1995，59，21： | 1 |
| 20 | Contracting and information sharing under supply chain eompetition显示文摘 | HAA Y TONG S L | 2008 | Management Science2008，54，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员