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| 1 | Forskolin and Phorbol 12-myristate 13-acetate modulates the expression pattern of AP-1 factors and cell cycle regulators in estrogen-responsive MCF-7 cells显示文摘Activator protein-1(AP-1)transcription factor is a key component of many signal transduction pathways involved in the regulation of cellular processes and controls rapid responses of mammalian cells when exposed to the variety of stimulus.The phorbol 12-myristate 13-acetate and Forskolin(Fo)are well-known kinase activators/stimulators of Protein Kinase C(PKC)and Protein Kinase A(PKA)respectively.Importantly,these kinases are found to be present in transitional points of many cell signaling pathways,especially those involved in proliferation.The stimulating effect of PKC and PKA on the expression of AP-1 factors in MCF-7 breast cell proliferation is not well characterized.Hence,the role of PKC by PMA treatment and the role of PKA by using Fo in MCF-7 cells is investigated.Where,cells treated with PMA showed increased cell proliferation,while Fo had no effect,but inhibited the PMA induced proliferation.The RT-PCR results showed the PMA induced c-Jun,c-Fos and Fra-1 expressions compared to control and Fo.However,Fo in combination with PMA,inhibit the PMA induced above mRNA expressions where Fo alone has no effect.Western blot studies validated the c-Jun expressions in PMA treated MCF-7 cells.Further,PMA increases the mRNA expression of Cyclin-E1,Cyclin-D1,and CDK-4,whereas Fo decreases their expressions.Thus,mitogenic effect of PMA and inhibitory action of Fo on MCF-7 cells is probably enhanced via activation of AP-1 factors and concomitant action of cell cycle regulators in the downstream singling cascade. | R.L.Babu M.Naveen Kumar Rajeshwari H.Patil K.M.Kiran Kumar K.S.Devaraju Govindarajan T.Ramesh S.Chidananda Sharma | 2019 | Genes & Diseases2019，6，2： | 2 |
| 2 | 浆纱时的纱线拉伸决定织造的经纱断头显示文摘通常纺织厂的生产能力由织机开口的效率决定,而开口效率取决于上浆织轴的质量。对原纱进行上浆加工时,纱线会受到拉伸,这是生产高质量上浆织轴需考虑的重要因素之一。张力引起的拉伸导致纱线伸长,以及纱线和纤维横截面减小,从而影响纤维强度。较高织造水平所需的高质量浆纱要求具有较高的断裂伸长率。如果断裂伸长率低于一定限度,织机上的经纱断头就将增加。为得到较高的断裂伸长率,浆纱时纱线拉伸率应尽可能小,特别是湿区的纱线拉伸率应越小越好。对不同线密度的棉纱、聚酯/棉混纺纱的纱线拉伸率、浆纱拉伸率和原纱伸长率的控制进行了研究,以降低织机上的经纱断头。 | R.N.Narkhedkar P.V.Kadole H.Patil 曾文敏 | 2014 | 国际纺织导报2014，，6： | 0 |
| 3 | Expeditious synthesis,antileishmanial and antioxidant activities of novel 3-substituted-4-hydroxycoumarin derivatives显示文摘A series of novel 3-substituted-4-hydroxycoumarin derivatives 6(a–1) were synthesized in high yield using one-pot three component coupling reaction catalyzed by ceric ammonium nitrate. These compounds were evaluated for antileishmanial activity against Leishmania donovani promastigotes and antioxidant activity(DPPH-radical scavenging activity). Two compounds, 6h(IC_(50)= 9.90 μmol/L) and 6i(IC_(50)= 6.90 μmol/L) displayed potent antileishmanial activity when compared with standard antileishmanial agents pentamidine(IC_(50)= 16.15 μmol/L) and miltefosine(IC_(50)= 12.50 μmol/L). Three compounds, 6c(IC_(50)= 10.79 μmol/L), 6h(IC50= 10.60 μmol/L), and 6i(IC_(50)= 10.73 μmol/L) showed significant antioxidant activity favorably with the antioxidant standards butylated hydroxy toluene(IC_(50)= 16.47 μmol/L) and ascorbic acid(IC_(50)= 12.69 μmol/L). A molecular docking study of compounds 6(a–1) suggested a possible mode of binding with the Adenine phosphoribosyltransferase enzyme of L.donovani. ADME properties were predicted in silico and support the potential of 6(a–1) to show favorable drug-like properties. | Zahid Zaheer Firoz A.Kalam Khan Jaiprakash N.Sangshetti Rajendra H.Patil | 2016 | Chinese Chemical Letters2016，27，2： | 0 |
| 4 | Metal nanoparticles as inhibitors of enzymes and toxins of multidrug-resistant Staphylococcus aureus显示文摘Staphylococcus aureus is an aerobic Gram-positive spherical bacterium known to cause a broad range of infections worldwide.It is a major cause of infective skin and soft infections and severe and life-threatening conditions,such as pneumonia,bloodstream infections,and endocarditis.The emergence of drug-resistant strains of S aureus,par-ticularly methicillin-resistant S aureus(MRSA),has become a significant concern in the healthcare community.Antibiotic-resistant S aureus is commonly acquired in hospitals and long-term care facilities.It often affects pa-tients with weakened immune systems,those undergoing invasive medical procedures,or those who have been hospitalized for extended periods.In the US,S aureus is known to cause potentially fatal illnesses,such as toxic shock syndrome(TSS)and acute-onset toxic shock syndrome(TSS),which are characterized by fever and hy-potension.It develops resistance to antibiotics through several mechanisms,such as the production of enzymes that inactivate antibiotics,target site modification,efflux pumps,and plasmid-mediated resistance.Therefore,preventing the spread of drug-resistant S aureus is needed,and there is an urgent need to explore novel ap-proaches in the development of anti-staphylococcal agents.This article reviews the principal infections caused by S aureus,major virulence factors,mechanisms of resistance development,and nanotechnology-based solutions for the control of drug-resistant S aureus. | Amruta A.Joshi Ravindra H.Patil | 2023 | Infectious Medicine2023，2，4： | 0 |
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