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3篇 您的检索式：作者名="H.Kaufmann"

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		题名	作者	年代	出处	被引量
	1	Resistance to venetoclax and hypomethylating agents in acute myeloid leukemia显示文摘Despite the success of the combination of venetoclax with the hypomethylating agents(HMA)decitabine or azacitidine in inducing remission in older,previously untreated patients with acute myeloid leukemia(AML),resistance-primary or secondary-still constitutes a significant roadblock in the quest to prolong the duration of response.Here we review the proposed and proven mechanisms of resistance to venetoclax monotherapy,HMA monotherapy,and the doublet of venetoclax and HMA for the treatment of AML.We approach the mechanisms of resistance to HMAs and venetoclax in the light of the agents’mechanisms of action.We briefly describe potential therapeutic strategies to circumvent resistance to this promising combination,including alternative scheduling or the addition of other agents to the HMA and venetoclax backbone.Understanding the mechanisms of action and evolving resistance in AML remains a priority in order to maximize the benefit from novel drugs and combinations,identify new therapeutic targets,define potential prognostic markers,and avoid treatment failure.	Antoine N.Saliba August J.John Scott H.Kaufmann	2021	Cancer Drug Resistance2021，4，1：	2
	2	Therapy‐related acute promyelocytic leukemia: observations relating to APL pathogenesis and therapy*显示文摘	Michelle A.Elliott LouisLetendre AyalewTefferi William J.Hogan ChristopherHook Scott H.Kaufmann Rajiv K.Pruthi AnimeshPardanani Kebede H.Begna Aneel A.Ashrani Alexandra P.Wolanskyj ArefAl‐Kali Mark R.Litzow	2012	European Journal of Haematology2012，，3：	1
	3	How CHKing ROS signaling preserves genomic integrity显示文摘In a recent study published in Cell,Zhang et al.broadly identify proteins modified during oxidative stress induced by H_(2)O_(2) or chemotherapy drugs and establish the DNA damage protein CHK1 as a key regulator of mitochondrial ROS.	Annapoorna Venkatachalam Scott H.Kaufmann	2023	Cell Research2023，33，11：	0

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