|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Third order nonlinear optical properties of substituted poly (p-phenylene vinylene) derivatives 显示文摘 | H L Li S Rentsch H Bergner | 1991 | Institute of Physics Conference Series1991，126，： | 1 |
| 2 | Dialysate related cytokine induction and response to recombinant human erythropoietin in haemodialysis patients显示文摘 | Sitter T Bergner A Schiffl H | 2000 | Nephrol Dial Transplant2000，15，8： | 1 |
| 3 | Flux dependenee of cluster formation in neutron-irradiated weld material显示文摘 | Bergner F Ulbrieht A Hein H | 2008 | J Phys Condens Matter2008，20，10： | 1 |
| 4 | Dialysate related cytokine induction and response to recombinant human erythropoietin in haemodialysis patients显示文摘 | Sitter T Bergner A Schiffl H | 2000 | Nephrol Dial Transplant2000，15，8： | 1 |
| 5 | The effects of treated straw meal on ileal and faecal digestibility of nutrients in pigs显示文摘 | PARTRIDGE I G SIMON O BERGNER H | 1986 | Archives of Animal Nutrition1986，36，45： | 1 |
| 6 | N-Stoffweehsel und seine Regelmechanismen显示文摘 | Bergner H | 1989 | Arehiv für Tierernahrung1989，39，： | 1 |
| 7 | 查看详情显示文摘 | Schiffl H Lang SM Bergner A | | 0，，： | 1 |
| 8 | Establishment,functional and genetic characterization of three novel patient-derived rectal cancer cell lines显示文摘AIM To establish patient-individual tumor models of rectal cancer for analyses of novel biomarkers, individual response prediction and individual therapy regimens.METHODS Establishment of cell lines was conducted by direct in vitro culturing and in vivo xenografting with subsequent in vitro culturing. Cell lines were in-depth characterized concerning morphological features, invasive and migratory behavior, phenotype, molecular profile including mutational analysis, protein expression, and confirmation of origin by DNA fingerprint. Assessment of chemosensitivity towards an extensive range of current chemotherapeutic drugs and of radiosensitivity was performed including analysis of a combined radioand chemotherapeutic treatment. In addition, glucose metabolism was assessed with 18 F-fluorodeoxyglucose(FDG) and proliferation with 18 F-fluorothymidine.RESULTS We describe the establishment of ultra-low passage rectal cancer cell lines of three patients suffering from rectal cancer. Two cell lines(HROC126, HROC284 Met) were established directly from tumor specimens while HROC239 T0 M1 was established subsequent to xenografting of the tumor. Molecular analysis classified all three cell lines as CIMP-0/non-MSI-H(sporadic standard) type. Mutational analysis revealed following mutational profiles: HROC126: APC^(wt), TP53^(wt), KRAS^(wt), BRAF^(wt), PTEN^(wt); HROC239 T0 M1: APC^(mut), P53^(wt), KRAS^(mut), BRAF^(wt), PTEN^(mut) and HROC284 Met: APC^(wt), P53^(mut), KRAS^(mut), BRAF^(wt), PTEN^(mut). All cell lines could be characterized as epithelial(EpCAM+) tumor cells with equivalent morphologic features and comparable growth kinetics. The cell lines displayed a heterogeneous response toward chemotherapy, radiotherapy and their combined application. HROC126 showed a highly radio-resistant phenotype and HROC284 Met was more susceptible to a combined radiochemotherapy than HROC126 and HROC239 T0 M1. Analysis of 18 F-FDG uptake displayed a markedly reduced FDG uptake of all three cell lines after combined radiochemotherapy. CONCLUSION These newly established and in-depth characterized ultra-low passage rectal cancer cell lines provide a useful instrument for analysis of biological characteristics of rectal cancer. | Michael Gock Christina S Mullins Carina Bergner Friedrich Prall Robert Ramer Anja Goder Oliver H Kramer Falko Lange Bernd J Krause Ernst Klar Michael Linnebacher | 2018 | World Journal of Gastroenterology2018，24，43： | 1 |
| 9 | dialysate related cytokines induction and response to recombinant human erythropoietin in hemodialysis patients显示文摘 | SITTER T BERGNER A SCHIFFL H | 2000 | Nephrol Dial Transplant2000，15，： | 1 |
| 10 | Dialysate related cytokine induction and response to recombi-nant human erythropoietin in haemodialysis patients 显示文摘 | Sitter T Bergner A Schiffl H | 2000 | Nephrol Dial Transplant2000，15，8： | 1 |
| 11 | Dialysate related cytokine induction and response to recombinant human erythropoietin in haemodialysis pa- tients 显示文摘 | Sitter T Bergner A Schiffl H | 2000 | Nephml Dial Transplant2000，15，8： | 1 |
| 12 | N-Stoffwechsel und seine Regelmechanismen显示文摘 | Bergner H | 1989 | Archiv für Tierernhrung1989，39，： | 1 |
| 13 | Acceleration of irradiation hardening of low- copper reactor pressure vessel steel observed by means of SANS and tensile testing显示文摘 | Bergner F Ulbricht A Viehrig H W | 2009 | Philosophical Magazine Letters2009，89，： | 1 |
| 14 | Ultrapure dialysate reduces dose of recombinant human erythropoietin显示文摘 | SCHIFFL H LANG S M BERGNER A | 1999 | Nephron1999，83，3： | 1 |
| 15 | Dialysate related cytokine induction and response to recombinant human erythropoietin in haemodialysis patients显示文摘 | Sitter T Bergner A Schiffl H | | 0，，： | 1 |
| 16 | Titanium powder sintering for preparation of a porous functionally graded material destined for orthopaedic implants显示文摘 | THIEME M WIETERS K P BERGNER F SCHARNWEBER D WORCH H NDOP J KIM T J GRILL W | 2001 | Journal of Materials Science:Materials in Medicine2001，12，： | 1 |
| 17 | Dialysote related cytokine induction and response to recombinant human erythropoietin in haemodiolysis patients显示文摘 | Sitter T Bergner A Schiffl H | 2000 | Nephrol Dial Transplant2000，15，8： | 1 |
| 18 | Ab initio energy-adjusted pseudopotentials for elements of group 13-17 显示文摘 | Dolg M Kchle W Stoll H and Preuss H | 1993 | Molecular Physics1993，80，： | 1 |
| 19 | Dialysate related cytokine induction and response to recombinant human erythropoietin in themodiylsis patients显示文摘 | Sitter T Bergner A Schiffl H | 2000 | NephrolDialysisTransplantation2000，15，： | 1 |
| 20 | Human β-tryptase is a ring-like tetramer with active sites facing a central pore显示文摘 | Pereira PJB Bergner A Macedo Ribeiro S Huber R Matschiner G Fritz H | 1998 | Nature1998，392，6673： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员