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| 1 | Contrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction显示文摘AIM:To investigate perfusion change in contrastenhanced ultrasonography(CEUS) to evaluate liver fibrosis based on biliary obstruction using an animal model.METHODS:New Zealand white rabbits(3-4 kg) underwent bile duct ligation to form a biliary obstruction model.We performed liver CEUS and laboratory tests on the day before the operation(day 0) and every 7 postoperative days until the rabbits were sacrificed.After CEUS,signal intensity of liver parenchyma with a time-intensity curve was analyzed.Perfusion parameters were automatically calculated from regionof-interests,including peak signal intensity,mean transit time,area under the curve and time to peak.Histological grades of liver fibrosis were assessed according to the Metavir score system immediately after sacrifice.Generalized estimating equations were used to analyze the association between liver fibrosis grades and perfusion parameters for statistical analysis.The perfusion parameters were measured on the last day and the difference between day 0 and the last day were evaluated.RESULTS:From the nine rabbits,histological grades of liver fibrosis were grade 1 in one rabbit,grade 2 and 3 in three rabbits each,and grade 4 in two rabbits.Among the four CEUS parameters,only the peak signal intensity measured on the last day demonstrated a significant association with liver fibrosis grades(OR =1.392,95%CI:1.114-1.741,P =0.004).The difference in peak signal intensity between day 0 and the last dayalso demonstrated an association with liver fibrosis(OR =1.191,95%CI:0.999-1.419,P =0.051).The other parameters tested,including mean transit time,area under the curve,and time to peak,showed no significant correlation with liver fibrosis grades.CONCLUSION:This animal study demonstrates that CEUS can be used to evaluate liver fibrosis from biliary obstruction using peak signal intensity as a parameter. | Hyun Joo Shin Eun Young Chang Hye Sun Lee Jung Hwa Hong Gyuri Park Hyun Gi Kim Myung-Joon Kim Mi-Jung Lee | 2015 | World Journal of Gastroenterology2015，21，9： | 4 |
| 2 | Mxil,a protein that specifically interacts withMax to bind Myc-Max recognition sites显示文摘 | Zervos AS Gyuris J Brent R, | 1993 | Cell1993，72，： | 1 |
| 3 | Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor显示文摘 | Choi HS Gyuris J | 1995 | Mol Endocrinol1995，9，： | 1 |
| 4 | Sexual imprint- ing in human mate choice显示文摘 | Bereezkei T Gyuris P & Weisfeld G E | 2004 | Proceedings of the Royal Society B: Biological Sciences2004，271，1544： | 1 |
| 5 | The chromatintargeting protein Brd2 is required for neural tube closure and embryogenesis 显示文摘 | Gyuris A Donovan DJ Seymour KA | 2009 | Biochim Biophys Acta2009，1789，5： | 1 |
| 6 | Alkaloids from Leucojum vernum and antiretroviral activity of amaryllidaceae alkaloids 显示文摘 | Szlavik L Gyuris A Minarovits J | 2004 | Planta Med2004，70，9： | 1 |
| 7 | Mxil, a protein that spe- cifically interacts with Max to bind Myc - Max recognition sites 显示文摘 | ZERVOS A S GYURIS J BRENT R | 1993 | Cell1993，72，2： | 1 |
| 8 | Sexual imprinting in human mate choice 显示文摘 | Bereczker T Gyuris P Weisfeld GE | 2004 | Proc Roy Soc B2004，271，1544： | 1 |
| 9 | Homogamy,genetic similarity,and imprinting;parental influence on mate choice preferences显示文摘 | Bereczkei T Gyuris P Koves P | 2002 | Personality and Individual Differences2002，33，5： | 1 |
| 10 | Sexual imprinting in human mate choice显示文摘 | Bereczkei T Gyuris P Weisfeld G E | 2004 | Proceedings of the Royal Society of B:Biological Sciences2004，271，1544： | 1 |
| 11 | Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor 显示文摘 | Lee JW Choi I-IS Gyuris J | 1995 | Mol Endocrinol1995，9，2： | 1 |
| 12 | Dipeptidyl peptidase activity of CD26 in serum and urine as a marker of cholestasis:experimental and clinical evidence显示文摘 | Perner F Gyuris T Rakoczy G | 1999 | J Lab Clin Med1999，134，1： | 1 |
| 13 | Combined Use of Collision Cell Technique and Methanol Addition for the Analysis of Arsenic in a High-chloride-containing Sample by ICP-MS 显示文摘 | Jinsung A Junseok L Gyuri L | 2015 | Microchemieal Journal2015，120，： | 1 |
| 14 | Dimerization of the human papillomavirus E7 oncoprotein in viv显示文摘 | Clemens K E Brent R Gyuris J | 1995 | Virology1995，214，1： | 1 |
| 15 | Epitope mapping of the Syrian hamster prion protein utilizing chimeric and mutant genes in a vaccinia virus expression system显示文摘 | Rogers M Serban D Gyuris T | 1991 | J Immunol1991，147，10： | 1 |
| 16 | Asses of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor显示文摘 | Lee JW Choi HS Gyuris J | 1995 | Mol Endocrinol1995，9，2： | 1 |
| 17 | The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis 显示文摘 | Gyuris A Donovan DJ Seymour KA | 2009 | Biochim Biophys Acta2009，1789，： | 1 |
| 18 | Alkaloids from Leucojum vernum and antiretroviral activity of Amaryllidaceae al- kaloids 显示文摘 | SZLAVIK L GYURIS A MINAROVITS J | 2004 | Planta Med2004，70，9： | 1 |
| 19 | Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor显示文摘 | Lee J W Choi H S Gyuris J | 1995 | Mol Endocrinol1995，9，2： | 1 |
| 20 | Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor显示文摘 | Lee JW Choi HS Gyuris J | 1995 | Mol Endocrinol1995，9，2： | 1 |
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