|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Urban sustainability in the presence of flood and geological hazards: The development of a GIS-based vulnerability and risk assessment methodology显示文摘 | Michael Fedeski Julie Gwilliam | 2007 | Landscape and Urban Planning2007，，1： | 3 |
| 2 | Impurity induced disordering in InGaAs/InGaAlAs quantum wells using implanted fluorine and boron显示文摘 | Bryce A C Marsh J H Gwilliam R | 1991 | IEEE Proceeding-J1991，38，2： | 2 |
| 3 | The genome sequence of Schizosaceharomyces pombe显示文摘 | Wood V Gwilliam R Rajandream M A | 2002 | Nature2002，45，6874： | 1 |
| 4 | A review of issues in transit economics 显示文摘 | GWILLIAM K | 2008 | Research in Transportation Economics2008，，23： | 1 |
| 5 | Gamma-glutamyl carboxyl- ase (GGCX) microsatellite and warfarin dosing 显示文摘 | Chen LY Eriksson N Gwilliam R | 2005 | Blood2005，106，10： | 1 |
| 6 | An efficient room-temperature silicon-based lightemitting diode显示文摘 | Ng W L Lourenco M A Gwilliam R M Ledain S Shao G Homewood K P | | 0，，6825： | 1 |
| 7 | 炎症过程中载脂蛋白E亚型在星形胶质细胞和小胶质细胞的表达和分泌显示文摘神经炎症是神经退行性疾病的常见特征,受阿尔茨海默病危险因素载脂蛋白E(APOE)的调节。apoE蛋白在大脑中由星形胶质细胞和小胶质细胞合成。在人类APOE(E2、E3和E4)靶向替代小鼠的星形胶质细胞和小胶质细胞的原代培养物中,我们发现星形胶质细胞分泌2种apoE,而细胞内apoE只包含1种。2种形式的分泌型星形胶质细胞apoE在糖蛋白分离过程中均发生结合,酶促去除聚糖使2种形式的apoE融合为单一形式。因此,星形胶质细胞分泌的2种apoE是不同的糖基化的蛋白。小胶质细胞仅释放1种apoE,而细胞内apoE则由2种形式组成;分泌的apoE和2种细胞内apoE中的其中1种是糖基化的。我们用内源性肿瘤坏死因子α(TNFα)或外源性脂多糖(LPS)促炎刺激物处理原代培养的胶质细胞。LPS对星形细胞的apoE没有影响,而APOE2和APOE3小胶质细胞释放的apoE增加;对APOE4小胶质细胞也没有影响。与APOE2和APOE3小胶质细胞相比,APOE4小胶质细胞显示出更高的TNFα基线分泌。TNFα处理仅降低了APOE4星形胶质细胞中apoE的分泌和细胞表达。星形胶质细胞和小胶质细胞产生apoE种类的模式不受炎症的影响。2种处理后的星形胶质细胞中均未显示APOE mRNA的变化。总之,我们的数据表明,星形胶质细胞和小胶质细胞差异表达和分泌糖基化形式的apoE;并且相较于APOE2和APOE3,APOE4星形胶质细胞和小胶质细胞在免疫调节方面存在缺陷。 | Maria Fe Lanfranco Jordy Sepulveda Gregory Kopetsky GWilliam Rebeck 杜一星(编译) | 2021 | 神经损伤与功能重建2021，16，6： | 1 |
| 8 | Extraordinary opti- cal gain from silicon implanted with erbium显示文摘 | Lourenco M A Gwilliam R M Homewood K P | 2007 | Appl Phys Lett2007，91，14： | 1 |
| 9 | Reproducibility of soft tissue landmarks on three-dimensional facial scans显示文摘 | Gwilliam JR Cunningham SJ Hutton T | 2006 | European journal of orthodontics2006，28，5： | 1 |
| 10 | An analysis of outcomes and treatment costs for children undergoing sple- nectomy for chronic immune thrombocytopenia purpura 显示文摘 | Gwilliam NR Lazar DA Brandt ML | 2012 | J Pediatr Surg2012，，47： | 1 |
| 11 | The use of 16S rDNA clone libraries to describe the microbial diversity of activated sludge communities 显示文摘 | Blackall L L Burrell P C Gwilliam H | 1998 | Water Sci Technol1998，37，4： | 1 |
| 12 | An efficient room-temperature silicon-based light-emitting diode显示文摘 | Ng W L Lourenco M A Gwilliam R M Ledain S Shao G Homewood K P | | 0，，6825： | 1 |
| 13 | Electrical characterization of silicon nitride produced by plasma immersion ion implantation 显示文摘 | GWILLIAM R M SHANNON J M CHEN S M | 1997 | Surf Coat Tech1997，93，： | 1 |
| 14 | The genome sequence of Schizosaccharomyces pombe 显示文摘 | Wood V Gwilliam R Rajandream M A | 2002 | Nature2002，415，： | 1 |
| 15 | An efficient room-temperature silicon-based light-emitting diode显示文摘 | NG W L LOURENCO M A GWILLIAM R M | 2001 | Nature2001，410，： | 1 |
| 16 | An efficient room-temperature silicon-based light-emitting diode 显示文摘 | NG W L LOURENCO M GWILLIAM R | 2001 | Nature2001，410，6825： | 1 |
| 17 | The use of 16SrDNA clone libraries to describe the microbial diversity of activated sludge communities显示文摘 | Blackall L L Burrell P C Gwilliam H | 1998 | Water Sci Technol1998，37，4： | 1 |
| 18 | The use of 16S rDNA clone libraries to describe the microbial diversity of activated sludge communities 显示文摘 | Blackall L L Burrell P C Gwilliam H | 1998 | Water Science and Technology1998，37，45： | 1 |
| 19 | An Efficient Room-temperature Silicon-based Lighit-emitting Diode 显示文摘 | Wai L N Lourenco M A Gwilliam R M | 2001 | Nature2001，410，： | 1 |
| 20 | The relationship be- tween categories of non-audit services and audit fees: evidence from UK companies显示文摘 | Ezzamel M Gwilliam D R Holland K M | 2002 | International Journal of Auditing2002，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员