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| 1 | Effect of alcohol consumption on liver stiffness measured by transient elastography显示文摘AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or continuation.METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver disease.TE was performed at least one week apart by senior operator.TE examinations with less than ten successful measures or with an interquartile range above 30% were excluded.We retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was available.Concomitant biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were recorded.Putative fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis C.Initial and final putative fibrosis score were compared according to alcohol consumption during follow-up.RESULTS:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two examinations.Thirty-seven patients met our criteria with a median follow-up of 32.5 wk.At the end of the study,13(35%) were abstinent,and 24(65%) relapsers.Eight patients had liver biopsy during follow-up.TE decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off value.In relapsers TE increased in 45% and decreased in 54% of patient.There was no statistical difference between initial and final TE in relapsers.In the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final TE.Using 19.5 kPa as cut-off for cirrhosis,7 patients had cirrhosis at initial TE and 5 patients had cirrhosis at final TE.Using 12.5 kPa as cut-off for cirrhosis,16 patients had cirrhosis at initial TE and 15 patients had cirrhosis at final TE.Evolution of biological data was in accordance with the relapse or abstinent status:abstinence ratio(duration of abstinence/duration follow-up) was correlated with AST ratio(r =-0.465,P = 0.007) and GGT ratio(r =-0.662,P<0.0001).GGT was correlated with initial(r = 0.488,P = 0.002) and final TE(r = 0.49,P<0.005).Final TE was correlated with AST(r = 0.362,P<0.05).Correlation between TE ratio and AST ratio(r = 0.44,P = 0.01) revealed that TE varied proportionally to AST for all patients irrespective of their alcohol status.The same relationship was observed between TE ratio and GGT ratio(r = 0.65,P<0.0001).Evolution of TE was significantly correlated with the ratio of time of abstinence to observation time(r =-0.387,P = 0.016) and the evolution of liver enzymes.CONCLUSION:TE significantly decreased with abstinence.Results of TE in alcoholic liver disease cannot be interpreted without taking into account alcohol consumption and liver enzymes. | Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot Dominique Guyader Romain Moirand | 2013 | World Journal of Gastroenterology2013，19，4： | 20 |
| 2 | “Smart”nanomaterials for cancer therapy显示文摘Recent development in nanotechnology has provided new tools for cancer therapy and diagnostics.Because of their small size,nanoscale devices readily interact with biomolecules both on the cell surface and inside the cell.Nanomaterials,such as fullerenes and their derivatives,are effective in terms of interactions with the immune system and have great potential as anticancer drugs.Comparatively,other nanomaterials are able to load active drugs to cancer cells by selectively using the unique tumor environment,such as their enhanced permeability,retention effect and the specific acidic microenvironment.Multifunctional and multiplexed nanoparticles,as the next generation of nanoparticles,are now being extensively investigated and are promising tools to achieve personalized and tailored cancer treatments. | LE GUYADER Laurent | 2010 | Science China Chemistry2010，53，11： | 4 |
| 3 | Iron metabolism imbalance at the time of listing increases overall and infectious mortality after liver transplantation显示文摘BACKGROUND Liver transplantation(LT)is the best treatment for patients with liver cancer or end stage cirrhosis,but it is still associated with a significant mortality.Therefore identifying factors associated with mortality could help improve patient management.The impact of iron metabolism,which could be a relevant therapeutic target,yield discrepant results in this setting.Previous studies suggest that increased serum ferritin is associated with higher mortality.Surprisingly iron deficiency which is a well described risk factor in critically ill patients has not been considered.AIM To assess the impact of pre-transplant iron metabolism parameters on posttransplant survival.METHODS From 2001 to 2011,553 patients who underwent LT with iron metabolism parameters available at LT evaluation were included.Data were prospectively recorded at the time of evaluation and at the time of LT regarding donor and recipient.Serum ferritin(SF)and transferrin saturation(TS)were studied as continuous and categorical variable.Cox regression analysis was used to determine mortality risks factors.Follow-up data were obtained from the local and national database regarding causes of death.RESULTS At the end of a 95-mo median follow-up,196 patients were dead,38 of them because of infections.In multivariate analysis,overall mortality was significantly associated with TS>75%[HR:1.73(1.14;2.63)],SF<100μg/L[HR:1.62(1.12;2.35)],hepatocellular carcinoma[HR:1.58(1.15;2.26)],estimated glomerular filtration rate(CKD EPI Cystatin C)[HR:0.99(0.98;0.99)],and packed red blood cell transfusion[HR:1.05(1.03;1.08)].Kaplan Meier curves show that patients with low SF(<100μg/L)or high SF(>400μg/L)have lower survival rates at 36 mo than patients with normal SF(P=0.008 and P=0.016 respectively).Patients with TS higher than 75%had higher mortality at 12 mo(91.4%±1.4%vs 84.6%±3.1%,P=0.039).TS>75%was significantly associated with infection related death[HR:3.06(1.13;8.23)].CONCLUSION Our results show that iron metabolism imbalance(either deficiency or overload)is associated with post-transplant overall and infectious mortality.Impact of iron supplementation or depletion should be assessed in prospective study. | Elodie Fallet Michel Rayar Amandine Landrieux Christophe Camus Pauline Houssel-Debry Caroline Jezequel Ludivine Legros Thomas Uguen Martine Ropert-Bouchet Karim Boudjema Dominique Guyader Edouard Bardou-Jacquet | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 4 | Insulin resistance–associated hepatic iron overload显示文摘 | Michel-Henry Mendler Bruno Turlin Romain Moirand Anne-Marie Jouanolle Thierry Sapey Dominique Guyader Jean-Yves le Gall Pierre Brissot Véronique David Yves Deugnier | 1999 | Gastroenterology1999，，5： | 2 |
| 5 | Noise Feedback Coding Revisited:Refurbished Legacy Codecs and New Coding Models显示文摘Noise feedback coding(NFC) has attracted renewed interest with the recent standardization of backward-compatible enhancements for ITU-T G.711 and G.722.It has also been revisited with the emergence of proprietary speech codecs,such as BV16,BV32,and SILK,that have structures different from CELP coding.In this article,we review NFC and describe a novel coding technique that optimally shapes coding noise in embedded pulse-code modulation(PCM) and embedded adaptive differential PCM(ADPCM).We describe how this new technique was incorporated into the recent ITU-T G.711.1,G.711 App.III,and G.722 Annex B(G.722B) speech-coding standards. | Stéphane Ragot Balázs Kvesi Alain Le Guyader | 2012 | ZTE Communications2012，10，2： | 2 |
| 6 | Liveriron is a surrogate marker of severe fibrosis in chronic hepatitis C显示文摘 | GUYADER D THIROUARD A S ERDTMANN L | 2007 | J Hepatol2007，46，4： | 1 |
| 7 | Self-repelling snakes for topology-preserving segmentation models显示文摘 | Le GUYADER C VESE L A | 2008 | IEEE Transactions on Image Processing2008，17，5： | 1 |
| 8 | Sound radiation by finite cylindrical ring stiffened shells 显示文摘 | LAULAGNET B GUYADER J L | 1990 | Journal of Sound and VibIation1990，138，2： | 1 |
| 9 | Sound radiation by finite cylindrical ring stiffened shells显示文摘 | Laulagnet B Guyader J L | 1990 | Journal of Sound and Vibration1990，138，2： | 1 |
| 10 | Magnetic resonance imaging and assessment of liver iron content in genetic hemochromatosis显示文摘 | Guyader D Gandon Y Robert J Y | | 0，，3： | 1 |
| 11 | Sound Radiation from Finite Cylindrical Shells,Partially Covered with Longitudinal Strips of Compliant Layer显示文摘 | Laulagnet B Guyader J L | 1995 | Journal of Sound and Vibration1995，186，5： | 1 |
| 12 | Segmentation under geometrical conditions using geodesic active contours and interpolation using level set methods显示文摘 | Gout C Guyader C L Vese L | 2005 | Numer Algorithms2005，39，： | 1 |
| 13 | Sound radiation by finite cylindrical ring stiffened shells显示文摘 | Laulagnet B Guyader J L | 1990 | Journal of Sound and Vibration(ISSN0022-460X)1990，138，2： | 1 |
| 14 | Sound radiation by finite cylindrical ring stiffened shells显示文摘 | LAULAGNET B GUYADER J L | | 0，，02： | 1 |
| 15 | Detection and quantification of noroviruses in shellfish显示文摘 | Le Guyader Francoise S Parnaudeau Sylvain Schaeffer Julien | 2009 | Appl Environ Microbiol2009，75，3： | 1 |
| 16 | Sound radiation by finite cylindrical ring stiffened shells显示文摘 | GUYADER J L | 1990 | Journal of Sound and Vibration1990，138，2： | 1 |
| 17 | Magnitude of rainfall on viral contamination of the marine environment during gastroenteritis epidemics in human coastal population 显示文摘 | MIOSSEC L LE GUYADER F HAUGARREAU L | 2000 | Rev Epidemiol Sante2000，48，： | 1 |
| 18 | Evidence for loss of mitochondria in Microsporidia from amitochondrial-type HSP70 in Nosema locustae显示文摘 | Germot A Herve P Guyader H L | 1997 | Molecular and Biochemical Parasitology1997，87，： | 1 |
| 19 | Experiments on routes to chaos in ball bearings显示文摘 | MEVEL B GUYADER J L | 2008 | Journal of Sound and Vibration2008，318，3： | 1 |
| 20 | Sound radiationby finite cylindrical ring stiffened shells 显示文摘 | LAULAGNET B GUYADER J L | 1990 | Journal of Sound and Vibration1990，138，2： | 1 |
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