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| 1 | Impact of macrophage inflammatory protein-lct deficiency on atheroscle- rotic lesion formation, hepatic steatosis, and adipose tissue expansion 显示文摘 | Kennedy A Gruen ML Gutierrez DA | 2012 | PLoS One2012，7，31： | 1 |
| 2 | Recombinant rubistatin (r-Rub), an MVD disintegrin, inhibits cell migration and proliferation, and is a strong apoptotic inducer of the human melanoma cell line SK-Mel-28 显示文摘 | Carey CM Bueno R Gutierrez DA | 2012 | Toxicon2012，59，： | 1 |
| 3 | Anatomic dis tribution of pulmonary emboli at pulmonary angiography: Im plications for cross-sectional imaging显示文摘 | Zuckerman DA Gutierrez FR | 1996 | Radiology1996，199，： | 1 |
| 4 | Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice显示文摘Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s disease.However,there is data suggesting that inflammation plays a role in its development and progression.Indeed,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease models.The purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in mice.LCN were prepared by the nanoprecipitation method.Male Swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in mice.In the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in mice.However,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition test.Moreover,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 downregulation.Our study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 modulation.This study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(approval No.02-2015)on April 16,2015. | Maria Eduarda Ziani Gutierrez Anne Suély Pinto Savall Edina da Luz Abreu Kelly Ayumi Nakama Renata Bem Dos Santos Marina Costa Monteiro Guedes Daiana SilvaÁvila Cristiane Luchese Sandra Elisa Haas Caroline Brandão Quines Simone Pinton | 2021 | Neural Regeneration Research2021，16，4： | 1 |
| 5 | Anatomic distribution of pulmonary emboli at pulmonary angiography:implications for crosssectional imaging显示文摘 | Oser RF Zuckerman DA Gutierrez FR | 1996 | Radiology1996，199，： | 1 |
| 6 | IL-17 produced during Trypanosoma cruzi infection plays a central role in regulating parasite-induced myocarditis显示文摘 | da Matta Guedes PM Gutierrez FR Maia FL | 2010 | PloS Negl Trop Dis2010，4，2： | 1 |
| 7 | Anatomic distribution of pulmonary emboli at pulmonary angiography:Implications for cross-sectional imaging显示文摘 | Oser RF Zuckerman DA Gutierrez FR | 1996 | Radiology1996，199，1： | 1 |
| 8 | Field evalu- ation of the single intradermal cervical tuberculin test and the interferon- y assay for detection and eradication of bovine tu- berculosis in Spain显示文摘 | Gonzalez OR Gutierrez CB Nistal DA | 1999 | Vet Microbiol1999，70，12： | 1 |
| 9 | Anatomic distribution of pulmonary emboli at pulmonary angiography:implications for cross-sectional imaging显示文摘 | Oser RF Zuckerman DA Gutierrez FR | 1996 | Radiology1996，199，1： | 1 |
| 10 | Detection and subtyping of Actinobacillus pleuropneumoniae strains by PCR-RFLP analysis of the tbpA and tb pB genes 显示文摘 | Da la Puente-Redondo V A del Blanco N G Gutierrez Martin C B | 2000 | Res Microbiol2000，151，8： | 1 |
| 11 | Anatomic distribution of pulmonary emboli at pulmonary angiography: hnplications for cross-sectional imaging 显示文摘 | Oser RF Zuckerman DA Gutierrez FR | 1996 | Radiology1996，199，1： | 1 |
| 12 | Anatomic distribution of pulmonary emboli at pulmonary angiography:implications for spiral and electron-beam CT显示文摘 | Oser RF Euckerman DA Gutierrez FR | 1996 | Radiology1996，199，： | 1 |
| 13 | Recombinant rubistatin (r-Rub), an MVD disintegrin, inhibits cell mi- gration and proliferation, and is a strong apoptotic inducer of the human melanoma cell line SK-Mel-28 显示文摘 | Careya CM Bueno R Gutierrez DA | 2012 | Toxicon2012，59，2： | 1 |
| 14 | Effect of chemical composition on the induction of DNA damage by ur- ban airborne particulate matter 显示文摘 | Gutierrez - Castillo ME Roubicek DA Cebrian Gareia ME | 2006 | Environ Mrd Mutagen2006，47，3： | 1 |
| 15 | Field evaluatior of the single intradermal cervical tuberculin test and the interferon-7 assay for detection and eradication of bovine tuberculosis in Spain显示文摘 | Gonzalez OR Gutierrez CB Nistal DA | 1999 | Vet Mierobiol1999，70，： | 1 |
| 16 | Anatomic distrib ution of pulmon ary emboli atpulmonary angiography implications for cross-sectional imaging显示文摘 | Oser RF Zuckerman DA Gutierrez FR | 1996 | Radiology1996，199，： | 1 |
| 17 | Recombinant rubistatin (r-Rub), an MVD disintegrin, inhibits cell mi- gration and proliferation,and is a strong apoptotic inducer of the human melanoma cell line SK-Me1-28 显示文摘 | Careya CM Bueno R Gutierrez DA | 2012 | Toxicon2012，59，2： | 1 |
| 18 | Economic Viability of Production of Tree Parica (Schizolobium amazonicum Huber ex. Ducke) of Reforestation Project in the Municipality Paragominas-PA, Brazil显示文摘 | Manoel Tavares de Paula Altem Nascimento Pontes Helio Raymundo Ferreira Filho Lucy Anne Cardoso Lobao Gutierrez Ismael Matos da Silva Maria da Conceicao Silva Damasceno Aline Lima de Sena | 2014 | Journal of Life Sciences2014，8，12： | 0 |
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