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| 1 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 2 | Toxicity and survival in primary glioblastoma patients treated with concomitant plus adjuvant temozolomide versus adjuvant temozolomide: results of a single-institution, retrospective, matched-pair analysis显示文摘 | A. Gutenberg H. C. Bock G. Reifenberger W. Brück A. Giese | 2013 | Acta Neurochirurgica2013，，3： | 2 |
| 3 | Amplitudes of surface waves and magnitudes of shallow earthquakes显示文摘 | Gutenberg B | 1945 | Bulletin ofthe Seismological Society of America1945，35，1： | 1 |
| 4 | Immunopathology of primary hypophysitis: implications for pathogenesis显示文摘 | Gutenberg A Buslei R Fahlbusch R | 2005 | Am J Surg Pathol2005，29，3： | 1 |
| 5 | Immunopathology of primary hypophysitis :implications for pathogenesis 显示文摘 | Gutenberg A Buslei R Fahlbuscb R | 2005 | Am J Surg Pathol2005，9，3： | 1 |
| 6 | Amplitudes of P, PP, and S and magnitude of shallow earthquakes显示文摘 | Gutenberg B | 1945 | Bull Seism Soc Amer1945，35，： | 1 |
| 7 | Frequency of earthquakes in California显示文摘 | Gutenberg B Richter C F | 1944 | Bull Seism Soc Am1944，34，： | 1 |
| 8 | Tsunamis and earthquakes显示文摘 | Gutenberg B | 1939 | Bull Seismic Soc Amer1939，29，4： | 1 |
| 9 | Magnitude and energy of earthquakes显示文摘 | Gutenberg B Richter C F | 1956 | Ann Geofis1956，9，： | 1 |
| 10 | Frequency of earthquake in California 显示文摘 | Gutenberg Richter C F | 1944 | Bull seism Soc Amer1944，34，： | 1 |
| 11 | Primary hypophysitis: clinical-pathological correla-tions 显示文摘 | Gutenberg A | 2006 | Eur J Endocrinol2006，155，1： | 1 |
| 12 | Pregnancy, postpartum autoimmune thyroiditis, and autoimmune hypophysi- tis : intimate relationships 显示文摘 | Landek-Salgado MA Gutenberg A Lupi I | 2010 | Autoimmun Rev2010，9，3： | 1 |
| 13 | Frequency of earthquakes in California显示文摘 | Gutenberg B Richter C F | 1944 | Bull Seism Soc Amer1944，34，： | 1 |
| 14 | On Seismic Waves (Third Paper)显示文摘 | Gutenberg B Richter C F | | 0，，： | 1 |
| 15 | Frequency of earthquakes in California显示文摘 | Gutenberg R Richter C F | 1944 | Bull Seism Soc Am1944，34，4： | 1 |
| 16 | Frequency of earthquakes in California显示文摘 | GUTENBERG Beno RICHTER Charles F | 1944 | Bulletin of the Seismological Society of America1944，34，4： | 1 |
| 17 | Magnitude and energy of earthquakes显示文摘 | Gutenberg Richter | | 0，，： | 1 |
| 18 | Seismicity of the earth显示文摘 | Gutenberg B Richter C F | 1945 | Geological Society of America Bulletin1945，56，6： | 1 |
| 19 | Pregnancy,postpartum autoimmune thyroiditis,and autoimmune hypophysitis:intimate relationships显示文摘 | Landek-Salgado MA Gutenberg A Lupi I | 2010 | Autoimmun Rev2010，9，3： | 1 |
| 20 | Frequency of earthquakes in California显示文摘 | Gutenberg R C Richter F | 1944 | Bull Seismol Soc Am1944，34，： | 1 |
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