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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Serum lipids and uric acid relationship in ischemic thrombotic cerebrovascular disease显示文摘 | Bansal B C Gupta R R Bansal M R | 1975 | Stroke1975，6，： | 1 |
| 3 | Grapefruit juice reduces theoral bioavailability of fexofenadine but not desloratadine显示文摘 | Banfield C Gupta S Marino M | 2002 | ClinPharmacokinet2002，41，： | 1 |
| 4 | Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 sig- naling显示文摘 | Fillmore C M Gupta P B Rudnick J A | 2010 | Proc Natl Acad Sci USA2010，107，21： | 1 |
| 5 | Deposition, exhumation, and paleoclimate of an ancient lake deposit, Gale crater, Mars 显示文摘 | GROTZINGER J P GUPTA S MALIN M C | 2015 | Science2015，350，6257： | 1 |
| 6 | Three-to six-year follow-up of stand-alone BAK cages implanted by a single surgeon 显示文摘 | Button G Gupta M Barrett C Cammack P Benson D | 2005 | Sline J2005，5，： | 1 |
| 7 | The tribological properties of AI-CulSiCp metal-matrix composites fabricated using the rheocasting technique 显示文摘 | LIM S C GUPTA M REN L KWOK J K M | 1999 | Journal of Materials Processing Technolog1999，8090，： | 1 |
| 8 | Grapefruit juice reduces theoral bioavailability of fexofenadine but not desloratadine显示文摘 | Banfield C Gupta S Marino M | 2002 | ClinPharmacokinet2002，41，： | 1 |
| 9 | The crystallography and morphology of the S'-phase precipitate in an AI(CuMg) alloy显示文摘 | GUPTA A K GAUNT P CHATURVEDI M C | 1987 | Phil Mag A1987，55，3： | 1 |
| 10 | Telomerase activity in normal leukocytes and in hematologic malignancies显示文摘 | Counter C M Gupta J Harley C B | 1995 | Blood1995，85，9： | 1 |
| 11 | Wear resistant WC-Co composite hard coatings显示文摘 | Lim S C Gupta M Goh Y S | 1997 | Surface Engineering1997，13，3： | 1 |
| 12 | Utilizing con- forrnational changes for patterning thin films of recombinant spider silk proteins 显示文摘 | YOUNG S L GUPTA M HANSKE C | 2012 | Biomacromolecules2012，13，10： | 1 |
| 13 | Porous nylon-6 fibersvia a novel salt-induced electrospinng method显示文摘 | Gupta A Saquing C Afshari M | 2009 | Macromole-cules2009，42，3： | 1 |
| 14 | Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine显示文摘 | Banfield C Gupta S Marino M | 2002 | Clin Pharmacokinet2002，41，4： | 1 |
| 15 | Oxidative stress, inflammation, and cancer: How are they linked? 显示文摘 | Reuter S Gupta S C Chaturvedi M M | 2010 | Free Radical Biology and Medicine2010，49，11： | 1 |
| 16 | A system dynamics model for a multi-stage multi-line dual-card JIT-kanban system 显示文摘 | GUPTA Y P GUPTA M C | 1989 | In- ternational Journal of Production Research1989，27，2： | 1 |
| 17 | Evaluation of antimicrohial peptide nisin as a safe vaginal contraceptive agent in rabbits:in vitro and in vivo studies显示文摘 | REDDY K V R ARANHA C GUPTA S M | 2004 | Reproduction2004，128，1： | 1 |
| 18 | A genetic algorithm-based approach to cell composition and layout design problems显示文摘 | GUPTA Y GUPTA M C KUMAR A | 1996 | International Journal of Production Research1996，34，2： | 1 |
| 19 | A Parameteric Model for Synthetic Aperture Radar Measurements 显示文摘 | Gerry M J Potter L C Gupta I J | 1999 | IEEE Transactions on Antennas and Propagation1999，47，7： | 1 |
| 20 | Triterpenes and triterpene glycosides from Paradrymonia macrophylla显示文摘 | Terreaux C Maillard M C Gupta M P | | 0，，02： | 1 |
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