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| 1 | Exercise sustains the hallmarks of health显示文摘Exercise has long been known for its active role in improving physical fitness and sustaining health.Regular moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative and therapeutic strategy for various diseases.It is well-documented that exercise maintains and restores homeostasis at the organismal,tissue,cellular,and molecular levels to stimulate positive physiological adaptations that consequently protect against various pathological conditions.Here we mainly summarize how moderate-intensity exercise affects the major hallmarks of health,including the integrity of barriers,containment of local perturbations,recycling and turnover,integration of circuitries,rhythmic oscillations,homeostatic resilience,hormetic regulation,as well as repair and regeneration.Furthermore,we summarize the current understanding of the mechanisms responsible for beneficial adaptations in response to exercise.This review aimed at providing a comprehensive summary of the vital biological mechanisms through which moderate-intensity exercise maintains health and opens a window for its application in other health interventions.We hope that continuing investigation in this field will further increase our understanding of the processes involved in the positive role of moderate-intensity exercise and thus get us closer to the identification of new therapeutics that improve quality of life. | Yan Qiu Benjamin Fernández-García H.Immo Lehmann Guoping Li Guido Kroemer Carlos López-Otín Junjie Xiao | 2023 | Journal of Sport and Health Science2023，12，1： | 1 |
| 2 | Contribution of extracellular polymeric substances(EPS)to the sludge aggregation显示文摘 | L Xiaomeng S Guoping L Hongwei | 2010 | Environmental Science and Technology2010，44，11： | 1 |
| 3 | Kinetics of relative electrical conductivity and correlation with gas composition in modified atmosphere packaged bayberries (Myrica rubra Siebold and Zucearini) 显示文摘 | Guoping F Hongshun Y Yunfei L | 2005 | LWT2005，，38： | 1 |
| 4 | Clinical and prognostic value of elevated CA125 levels in patients with coronary heart disease 显示文摘 | Rong X Yunke Z Guoping L | 2014 | Herz2014，17，： | 1 |
| 5 | Observer Design for Descriptor Markovian Jumping System with Nonlinear Perturbations 显示文摘 | Xiaomei Z Guoping L Yufan Z | 2008 | Circuits System Process2008，27，1： | 1 |
| 6 | The improvement of weathering resistance by increasing P contents in cast strips of low carbon steels 显示文摘 | Guoping Z Zhenyu L Yiqing Q | 2009 | Materials & Design2009，30，10： | 1 |
| 7 | Isolation of methyl parathion - degrading strain M6 and cloning of the methyl parathion hydrolase gene 显示文摘 | Zhongli C L Shunpeng F Guoping | 2001 | Appl Environ Microbiol2001，67，10： | 1 |
| 8 | Effects of oxidized and glycated lowdensity lipoproteins on transcription and secretion of plasminogen activator inhibitor-1 in vascularendothelial cells显示文摘 | Guoping M Ma Andrew J Halayko Gerald L Stelmack | 2006 | Cardiovascular Pathology2006，15，： | 1 |
| 9 | Clinical and prognostic value of elevated CA125 levels in patients with coronary heart disease显示文摘 | Rong X Yunke Z Guoping L et a/ | 2015 | Herz2015，40，4： | 1 |
| 10 | Regional Output Spillovers in China:Estimates from a VAR Model显示文摘 | Groenewold N Guoping L &Anping C | 2007 | Regional Science2007，86，1： | 1 |
| 11 | Increased monocyte adhesion to aortic endothelium in rats with hyperhomocysteinemia role of chemokine and adhesion molecules显示文摘 | Guoping Wang Connie WH Fion L | 2002 | Arterioscler Thromb Vasc Biol2002，22，： | 1 |
| 12 | A new key frame representation for video segment retrieral显示文摘 | Kin-Wai S Kin-Man L Guoping Q | 2005 | IEEE Trans on Circuit and Systems for Video Tech2005，15，9： | 1 |
| 13 | Apolipoprotein B/ apolipoprotein A1 ratio and non-high-density lipoprotein cholesterol : Predictive value for CHD severity and prognostic utility in CHD patients显示文摘 | LITING P GUOPING L ZHENYUE C | 2015 | Herz2015，40，1： | 1 |
| 14 | Effects of SO_(2)derivatives on sodium currents in acutely isolated rat hippocampal lead-exposed neurons显示文摘In this study, the effects of acute SO_2 derivatives and chronic lead exposure together on sodium cur-rents (INa) were investigated in acutely isolated rat hippocampal neurons by using the whole-cell patch clamp techniques. We found that chronic lead exposure hardly reduced the amplitudes of INa. In the normal condition, sodium current started to appear at around ?70 mV, and reached the peak current at around ?40 mV. After chronic lead exposure, the data changed to ?70 and ?30 mV. After adding SO2 derivatives, the data changed to ?80 and ?40 mV, respectively. SO_2 derivatives caused a significant in-crease of INa in hippocampal chronic-lead exposed neurons. Chronic lead exposure induced a right shift of the activation curve and a left shift of the inactivation curve of sodium channels. SO_2 derivatives caused negative shifts of the activation and inactivation curves of INa in hippocampal chronic-lead ex-posed neurons. Lead exposure put off the time reaching the peak of INa activation. SO_2 derivatives in-creased the time constants of inactivation after lead exposure. The interaction of lead and SO_2 deriva-tives with voltage-dependent sodium channels may lead to changes in electrical activity and contribute to worsening the neurotoxicological damage. | DU ZhengQing Lü GuoPing | 2008 | Science China(Life Sciences)2008，51，9： | 1 |
| 15 | A new key frame representation for video segment retrieval 显示文摘 | Kin W S Kin M L Guoping Q | 2005 | IEEE Trans on Circuits and Systems for Video Technology2005，15，9： | 1 |
| 16 | A new key frame representation for video segment retrieval显示文摘 | Kin W S Kin M L Guoping Q | 2005 | IEEE Trans on Circuits and Systems for Video Technology2005，15，9： | 1 |
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