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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Investigation of Laminated Fabric Cages Used in Rolling Bearings by ToF - SIMS 显示文摘 | Gunst U Zabel W R Valle N | 2010 | Tribology International2010，43，56： | 1 |
| 3 | Esophageal Squamous cell cancer in paitients with head and neckcancer prevalence of human papillom virus DNA sequences显示文摘 | De Villiers EM Gunst K Stein H | 2004 | Int J Cancer2004，109，2： | 1 |
| 4 | The stromal cell-derived factor-lalpha/CXCR4 ligand-receptot axis is critical for progenitor survival and migration in the pancreas显示文摘 | KAYALI A G VAN GUNST K CAMPBELL I L | 2003 | J Cell Biol2003，163，4： | 1 |
| 5 | Role of protein kinase Calpha in regulation ofI and force in human myometrium显示文摘 | Fomin VP Kronbergs A Gunst S | 2009 | Reprod Sci2009，16，1： | 1 |
| 6 | Changing epidemiology of trauma deaths leads to a bimodal distribution显示文摘 | Gunst M Ghaemmaghami V Gruszecki A | 2010 | Proc(Bayl Univ Med Cent)2010，23，4： | 1 |
| 7 | Bone blood supply after change of implant显示文摘 | Gunst MA Rahn BA Ruedi T | 1985 | Helv Chir Acta1985，52，1： | 1 |
| 8 | Polyorchidism : a strange anoma- ly with unsuspected properties显示文摘 | Spranger R Gunst M Kuhn M | 2002 | J Urol2002，168，： | 1 |
| 9 | Esophageal squamous cell cancer in patients with head and neck cancer:prevalence of human papillo- mavirus DNA sequences显示文摘 | De Villiers EM Gunst K Stein H | 2004 | Int J Cancer2004，109，2： | 1 |
| 10 | Signal transduction in smooth muscle invited review:Focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle显示文摘 | Gerthoffer WT Gunst SJ | 2001 | J Appl Physiol2001，91，2： | 1 |
| 11 | Peripherally inserted central catheters may lower the incidence of catheter-related blood stream infections in patients in surgical intensive care units显示文摘 | Gunst M Matsushima K Vanek S | 2010 | Surg Infect (Larchmt)2010，，： | 1 |
| 12 | The impact of using esti- mated GFR versus creatinine clearance on the evaluation of recov- ery from acute kidneyinjury in the ICU显示文摘 | Schetz M Gunst J Van den Berghe G | 2014 | Intensive Care Med2014，40，11： | 1 |
| 13 | Interferon-induced proteins:identification of Mx proteins in various mammalian species 显示文摘 | Horisberger M A Gunst M C | 1991 | Virology1991，180，： | 1 |
| 14 | An auditory brain-computer interface (BCI) 显示文摘 | Nijboer F Furdea A Gunst I | 2008 | Journal of Neuroscience Methods2008，167，1： | 1 |
| 15 | The stromal cell-derived factor-1alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas显示文摘 | Kayali AG Van Gunst K Campbell IL | 2003 | Cell Biol2003，163，4： | 1 |
| 16 | Effect of length history on contractile behavior of canine tracheal smooth muscle 显示文摘 | Gunst SJ | 1986 | Am J Physiol1986，250，： | 1 |
| 17 | The contractile aaratus and mechanical roerties of airway smooth muscle显示文摘 | Gunst S J Tang DD | 2000 | Eur Resir J2000，15，3： | 1 |
| 18 | Th1 and Th2 pancreatic inflammation differentially affects homing of islet - reactive CD4 cells in nonobese diabetic mice 显示文摘 | Hill NJ Van Gunst K Sarvetnick N | 2003 | J Immunol2003，170，4： | 1 |
| 19 | , Mechanisms for the mechanical placticity of tracheal smooth muscle 显示文摘 | Gunst S J Meiss RA Wu MF | 1995 | Am J Physiol1995，268，： | 1 |
| 20 | Dynamic association between {alha}-actinin and {beta}-integrin regulates contraction of canine tracheal smooth muscle显示文摘 | Zhang W Gunst SJ | 2006 | J Physiol2006，572，3： | 1 |
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