|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Progress in surgical and nonsurgical approaches for hepatocellular carcinoma treatment显示文摘BACKGROUND:Hepatocellular carcinoma(HCC) is a complex and heterogeneous malignancy,frequently occurs in the setting of a chronically diseased organ,with multiple confounding factors making its management challenging.HCC represents one of the leading causes of cancer-related mortality globally with a rising trend of incidence in some of the developed countries,which indicates the need for better surgical and nonsurgical management strategies.DATA SOURCES:Pub Med database was searched for relevant articles in English on the issue of HCC management.RESULTS:Surgical resection represents a potentially curative option for appropriate candidates with tumors detected at earlier stages and with well-preserved liver function.The long-term outcome of surgery is impaired by a high rate of recurrence.Surgical approaches are being challenged by local ablative therapies such as radiofrequency ablation and microwave ablation in selected patients.Liver transplantation offers potential cure for HCC and also correction of underlying liver disease,and minimizes the risk of recurrence,but is reserved for patients within a set of criteria proposed for a prudent allocation in the shortage of donor organs.Transcatheter locoregional therapies have become the palliative standard allowing local control for intermediate stage patients with noninvasive multinodular or large HCC who are beyond the potentially curative options.The significant survival benefit with the multikinase inhibitor sorafenib for advanced HCC has shifted the direction of research regarding systemic treatment toward molecular therapies targeting the disregulated pathways of hepatocarcinogenesis.Potential benefit is suggested from simultaneous or sequential multimodal therapies,and optimal combinations are being investigated.Despite the striking progress in preclinical studies of HCC immunotherapy and gene therapy,extensive clinical trials are required to achieve successful clinical applications of these innovative approaches.CONCLUSION:Treatment decisions have become increasingly complex for HCC with the availability of multiple surgical and nonsurgical therapeutic options and require a comprehensive,multidisciplinary approach. | Ender Gunes Yegin Erkan Oymac1 Emrah Karatay Ahmet Coker | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，3： | 14 |
| 2 | The relationship between ischemic stroke and weather conditions in Duzce, Turkey显示文摘BACKGROUND: Weather conditions are thought to increase the risk of stroke occurrence. But their mechanism has not yet been clarified. We investigated possible relationships between ischemic stroke and weather conditions including atmospheric pressure, temperature, relative humidity, and wind speed.METHODS: One hundred and twenty-eight patients with ischemic stroke who had been admitted to our hospital between January 1 and December 31, 2010 were enrolled in this study. We investigated the relationship between daily cases and weather conditions the same day or 1, 2, and 3 days before stroke.RESULTS: A negative correlation was found between maximum wind speed and daily cases 3 days before stroke. As the relationship between daily cases and changes of weather conditions in consecutive days was evaluated, a negative correlation was found between daily cases and change of atmospheric pressure in the last 24 hours.CONCLUSIONS: The maximum wind speed 3 days before stroke and change of atmospheric pressure in the last 24 hours were found to increase the cases of ischemic stroke. We recommend that individuals at risk of ischemic stroke should pay more attention to preventive measures, especially on days with low maximum wind speed, on subsequent 3 days, and on days with low atmospheric pressure in the last 24 hours. | Harun Gunes Hayati Kandis Ayhan Saritas Suber Dikici Ramazan Buyukkaya | 2015 | World Journal of Emergency Medicine2015，6，3： | 6 |
| 3 | Tracheobronchopathia osteochondroplastica: four cases显示文摘 | Dursun Tatar Gunes Senol Atike Demir Gulru Polat | 2012 | Chinese Medical Journal2012，，16： | 4 |
| 4 | Differences in parents of pediatric liver transplantation and chronic liver disease patients显示文摘BACKGROUND With advancements in the treatment of chronic liver disease(CLD),including liver transplantation(LT),quality of life and satisfaction after LT have become an important issue for pediatric patients and their parents.More evidence-based information is needed to describe and assess the impact of pediatric CLD on parents and the satisfaction of parents with treatment to better understand their needs.AIM To assess the satisfaction of parents of pediatric LT patients and that of parents of pediatric CLD patients METHODS During this survey,data were collected from parents of pediatric patients who underwent LT between January 2010 and April 2017(LT group;n=91)and parents of pediatric patients with chronic liver disease(CLD group;n=94).Group comparisons were made based on the pediatric health-related quality of life(PedsQL)health care parent satisfaction scale,impact on family scale(IFS)and demographic characteristics.The PedsQL was administered to parents during a phone interview and the results were used to assess the health carerelated satisfaction of parents.The IFS was used to assess the impact of the child’s CLD status on the family.Demographic variables such as education level(elementary vs middle vs high vs university),monthly income(low vs middle vs high),and place of residence(village vs town vs city)were compared between CLD and LT parent groups.Finally,PedsQL and IFS results were also analyzed according to demographic variables.RESULTS A total of 185 parents aged 19 to 65 years were included.There were statistically significant differences between the LT and CLD groups in terms of career(P<0.001),monthly income(P=0.016),and education level(P=0.041).According to the PedsQL results,family inclusion,communication,technical skills,emotional needs,and overall satisfaction were significantly different between the groups;the LT group had consistently higher scores(P<0.001).Additionally,scores for the IFS parameters of financial impact,familial-social impact,personal strain,and total impact were consistently higher for the LT group(P<0.001).There were statistically significant relationships between education level,monthly income,and place of residence according to the IFS results but not the PedsQL results.There were inverse relationships between the difficulties that parents experience because of their child’s health and education levels,monthly income,and place of residence.However,no relationship was found between education level,monthly income,or place of residence and satisfaction with health care services provided in the hospital according to the PedsQL results.CONCLUSION Parents of children who underwent LT were very satisfied with the health care services provided to their children.However,they had more difficulties than parents of children with CLD. | Sami Akbulut Gulsen Gunes Hasan Saritas Bahar Aslan Yunus Karipkiz Khaled Demyati Sukru Gungor Sezai Yilmaz | 2020 | World Journal of Clinical Cases2020，8，11： | 3 |
| 5 | Carcinosarcoma of the gallbladder: Report of a case显示文摘 | Mehmet Ali Uzun Neset Koksal Yusuf Gunerhan Atilla Celik Pembegul Gune? | 2009 | Surgery Today2009，，2： | 2 |
| 6 | Incisional endometriosis after cesarean section, episiotomy and other gynecologic procedures 显示文摘 | Gunes M Kayikcioglu F Ozturkoglu E | 2005 | J Obstet Gynaecol Res2005，31，5： | 1 |
| 7 | Peanut/maize intercropping induced changes in rhizosphere and nutrient concentrations in shoots 显示文摘 | INAL A GUNES A ZHANG F | 2007 | Plant Physiology and Biochemistry2007，45，： | 1 |
| 8 | SOX4 expression levels in urothelial bladder carcinoma 显示文摘 | Gunes S Yegin Z Sullu Y Buyukalpelli R Bagci H | 2011 | Pathol Res Pract2011，207，7： | 1 |
| 9 | Erythropoietin protects the intestine against ischemia/reperfusion injury in rats显示文摘 | Guneli E Cavdar Z Islekel H | 2007 | M ol M ed2007，13，9： | 1 |
| 10 | HIF-lalpha regulates dif-ferentiation of limb bud mesenchyme and joint development显示文摘 | Provot S Zinyk D Gunes Y et cd | 2007 | J Cell Biol2007，177，： | 1 |
| 11 | A T-cen prolymphocytie leukemia case with central nervous system involvement 显示文摘 | MALKAN U Y GUNES G YAYAR O | 2015 | International Journal of Clinical and Experimental Medicine2015，15，14： | 1 |
| 12 | Effect of timing, IBA and Putrescine on rooting and shooting in Pyrus elaeagri folia pall softwood cuttings 显示文摘 | Dumano GH Aygun AA Gunes NT | 1999 | Hort Sic1999，69，11： | 1 |
| 13 | Value of brain natriuretic peptide after acute myocardial infarction显示文摘 | GUNES Y OKCUN B KAVLAK E | 2008 | Anadolu Kardiyol Derg2008，8，： | 1 |
| 14 | Progress on understanding debonding problems in reinforced concrete and steel members strengthened using FRP composites显示文摘 | Buyukozturk O Gunes O Karaca E | 2004 | Coust Building Mater2004，18，1： | 1 |
| 15 | Analysisi of vitamin D receptor gene polymorphisms in patients with chronic periodontitis 显示文摘 | Gunes S Sumer AP Keles GC | 2008 | Indian J Med Res2008，127，1： | 1 |
| 16 | The effect of oral L-camitine supplementation on the lipid profiles of hyperlipidaemic children显示文摘 | Gunes B Yalcin SS Kalkanoglu HS | 2005 | Aeta Paediatr2005，94，6： | 1 |
| 17 | Clinical profile and outcome of coronary artery ectasia显示文摘 | Gunes Y Boztosun B Yildiz A | 2006 | Heart2006，92，8： | 1 |
| 18 | Patter search optimization with applications on synthesis of linear antenna arrays显示文摘 | Gunes F Tokan F | 2010 | Expert Systems with applications2010，37，6： | 1 |
| 19 | Successful outpatient man-agement of the nonpalpable intra-abdominal testis withs taged fowlers-tephens orchiopexy显示文摘 | Cornelius D Gunes A | 2004 | JUrol2004，172，61： | 1 |
| 20 | Clinical Results of Tibial Pilon Fractures Treated by Open Reduction and Internal Fxation显示文摘 | Gunes O Ozcalabi ZT | 2003 | Aeta Orthopuedica Traumatologica Tureiea2003，37，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员