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| 1 | Surgical therapy and prognosis of sarcomatoid carcinoma of the gallbladder显示文摘BACKGROUND:Sarcomatoid carcinoma of the gallbladder is rare and its characteristics are poorly understood.This study aimed to understand the behavior and prognosis of sarcomatoid carcinoma of the gallbladder as well as its clinical manifestations and survival rate of patients after radical or palliative surgery,and to review the reported data worldwide and our 10 patients. METHODS:From 2004 to 2009,ten patients were pathologically diagnosed with sarcomatoid carcinoma of the gallbladder and underwent operation at our center.These characteristics,clinical presentations,tumor-node-metastasis(TNM)staging,surgical modes,and prognosis were reviewed,retrospectively.We collected the data of 46 patients reported in the English-language literature worldwide and analyzed the survival with ours.The survival rate was estimated using the Kaplan-Meier method,and was compared using the log-rank test. RESULTS:The median age of the 10 patients was 67 years (inter-quartile range 59-74 years),and the size of tumor inter- quartile ranged from 3.1 to 7.9 cm.In this series,9 patients received radical surgery,and one undewent palliative surgery. There was no surgical mortality,and one patient underwent a second operation because of liver metastasis.The median survival time of the patients was 9 months(inter-quartile range 6-12 months),with 3 patients still being alive until follow-up;however,two patients had tumor recurrence.The data from the 56 patients(10 patients in our series and 46 reported elsewhere)statistically indicated that the median age was 66 years(inter-quartile range 61-74.5 years)and the overall median survival was 5.5 months(inter-quartile range 2.5-10 months).The survival time in the patients undergoing radical surgery(n=42)was significantly longer than that in the patients undergoing palliative surgery(n=14)(P=0.031). CONCLUSIONS:The survival of the patients with sarcomatoid carcinoma of the gallbladder is poor.Some patients may die shortly after the surgery because of recurrence or metastasis. However,radical surgery is still necessary if possible. | Hu, Zhen-Hua Li, Zhi-Wei Shen, Liang Zhang, Min Zheng, Shu-Sen | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，2： | 16 |
| 2 | 胆囊肉瘤样癌1例报告显示文摘1病历简介病人女性,81岁,因'间断性右上腹疼痛1周伴乏力'于2013-11-20入院。既往有冠心病和2型糖尿病病史。查体:全身皮肤及巩膜无黄染,腹软,右上腹压痛,无反跳痛,Murphy征可疑阳性,肝脾肋下未触及,移动性浊音阴性。肝功能提示:谷氨酸转氨酶47 U/L,白蛋白28 g/L,碱性磷酸酶736 U/L。血常规提示:白细胞10.5×109/L,中性粒细胞百分比为82.3%,血红蛋白77 g/L。超声示:胆囊结石并胆囊炎,胆囊窝积液,肝脏多发实质性病灶。MRI示:胆囊炎并多发结石,不排除胆囊肿瘤,肝脏多发小结节,腹腔积液。剖腹探查发现,胆囊与大网膜、胃等粘连紧密并侵犯相邻组织,胆囊与网膜及右肝相侵犯处组织破裂出血。 | 严诗伟 任柏勇 | 2014 | 中国实用外科杂志2014，34，S1： | 2 |
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