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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Pancreatic pseudocyst 显示文摘 | Gumaste V Pitchumoni CS | 1996 | Gastr- oenterologist1996，4，1： | 1 |
| 3 | Significance of Pleural effusion in patients with acute pancreas显示文摘 | Gumaste V Singh V Dave P | 1992 | Am J Gastroenterol1992，87，： | 1 |
| 4 | Significance of pleural effusion in patients with acute pancreatitis显示文摘 | Gumaste V Dave P | 1992 | Am J Gastroenterol1992，，87： | 1 |
| 5 | Treatment of gastroparesis: an update 显示文摘 | Gumaste V Baum J | 2008 | Digestion2008，78，4： | 1 |
| 6 | Pancreatic pseudocyst显示文摘 | Gumaste V Pitchumoni CS | 1996 | Gastroenterologist1996，4，： | 1 |
| 7 | Significance of pleural effusion in patients with acute pancreatitis显示文摘 | Singh V Dave P | 1992 | Am J Gastroenterol1992，87，6： | 1 |
| 8 | Prophylactic antibiotic therapy in the management of acute pancreatitis显示文摘 | Gumaste V | 2000 | J Clin Gastroenterol2000，31，1： | 1 |
| 9 | Benign and malignant colorectal strictures in ulcerative colitis显示文摘 | Gumaste V Sachar DB Greenstein AJ | 1992 | Gut1992，33，7： | 1 |
| 10 | A mild and efficient method for the preparation of acyl azides from carboxylic acids using triphosgene显示文摘 | Gumaste V K Bhawal B M Deshmukh A R A S | 2002 | Tetrahedron Letters2002，43，： | 1 |
| 11 | Alkylation of benzene with long chain (C8-C18) linear primary alcohols over zeolite-Y显示文摘 | Deshmukh A R A S Gumaste V K Bhawal B M | 2000 | Catalysis Letter2000，，64： | 1 |
| 12 | Significance of pleural effusion in pa- tients with acute pancreatitis 显示文摘 | Gumaste V Singh V Dave P | 1992 | Am J Gastroenterol1992，87，7： | 1 |
| 13 | Corrosive ingestion in adults显示文摘 | Ramasamy K Gumaste V V | 2003 | J Clin Gastroenterol2003，37，2： | 1 |
| 14 | CT Colonography Can Be an Adjunct to Optical Colonoscopy in CRC Screening显示文摘 | Vivek V Gumaste | 2009 | Dig Dis Sci2009，54，： | 1 |
| 15 | Treatment of gastroparesis : an update显示文摘 | Gumaste V Baum J | 2008 | Digestion2008，78，4： | 1 |
| 16 | Pseudocyst management endo- scopic drainage and other emerging techniques显示文摘 | Gumaste V V Aron J | 2010 | Clin Castroenterol2010，44，5： | 1 |
| 17 | Pseudocyst management endo- scopic drainage and other emerging techniques显示文摘 | Gumaste V V Amn J | 2010 | J Clin Gastroenterol2010，44，5： | 1 |
| 18 | Treatment of gastroparesis:an update显示文摘 | Gumaste V Baum J | 2008 | Digestion2008，78，4： | 1 |
| 19 | Significance of pleural effusion in patients with acute pancreatitis显示文摘 | Gumaste V Singh V Dave P | 1992 | Am J Gastroenterol1992，87，7： | 1 |
| 20 | Analytical and experi-mental characterization of bonding over active circuitry显示文摘 | Zhang L Gumaste V Poddar A | 2007 | Jour-nal of Electronic Packaging2007，129，4： | 1 |
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