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| 1 | Reversible acetylation modulates dishevelled-2 puncta formation in canonical Wnt signaling activation显示文摘Dear Editor,Dishevelled-2(DVL2)is a central adaptor protein that propagates signals from upstream receptors to downstream effectorβ-catenin in canonical Wnt signaling.At high local concentration,DVL2 assembles into signalosomes through DIX domain-mediated homo-polymerization to provide a docking platform for the recruitment of signaling components,which is critical for Wnt signaling transduction and activation;1 however,the exact underlying mechanism remains inconclusive.Although the roles of phosphorylation and ubiquitination in DVL2-puncta formation have been discussed before,2 the impact of lysine acetylation of DVL2 on this process remains elusive.Here we investigated the effect of acetylation on DVL2-puncta formation. | Jinhong Shen Lin Hu Li Yang Mengshi Zhang Weihong Sun Xiaomei Lu Gufa Lin Chao Huang Xiaoren Zhang Y.Eugene Chin | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 2 | Activation of the Melanocortin-4 receptor signaling byα-MSH stimulates nervedependent mouse digit regeneration显示文摘Background:Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and regeneration.However,the expression and function of Mc4r in the mouse limb and digit has not been fully investigated.Our previous work showed that Mc4r−/−mice fail to regenerate the digit,but whether activation of MC4R signaling could rescue digit regeneration,or stimulate proximal digit regeneration is not clear.Results:We analyzed the expression dynamics of Mc4r in the embryonic and postnatal mouse limb and digit using the Mc4r-gfp mice.We found that Mc4r-GFP is mainly expressed in the limb nerves,and in the limb muscles that are undergoing secondary myogenesis.Expression of Mc4r-GFP in the adult mouse digit is restricted to the nail matrix.We also examined the effect ofα-MSH on mouse digit regeneration.We found that administration ofα-MSH in the Mc4r+/−mice rescue the delayed regeneration of distal digit tip.α-MSH could rescue distal digit regeneration in denervated hindlimbs.In addition,α-MSH could stimulate regeneration of the proximally amputated digit,which is non-regenerative.Conclusions:Mc4r expression in the mouse limb and digit is closely related to nerve tissues,andα-MSH/MC4R signaling has a neurotrophic role in mouse digit tip regeneration. | Hanqian Xu Hailin Zhang Yanqing Fang Huiran Yang Ying Chen Chao Zhang Gufa Lin | 2021 | Cell Regeneration2021，10，1： | 1 |
| 3 | High-resolution single-cell analysis paves the cellular path for brain regeneration in salamanders显示文摘Salamanders are excellent models for studying vertebrate brain regeneration,with the promise of developing novel therapies for human brain lesions.Yet the molecular and cellular mechanism of salamander brain regeneration remains largely elusive.The insight into the evolution of complex brain structures that lead to advanced functions in the mammalian brain is also inadequate.With high-resolution single-cell RNA sequencing and spatial transcriptomics,three recent studies have reported the differentiation paths of cells in the salamander telencephalon in the journal Science,bringing both old and new cell types into the focus and shedding light on vertebrate brain evolution,devel-opment,and regeneration. | Binxu Yin Xinyun Li Gufa Lin Heng Wang | 2022 | Cell Regeneration2022，11，1： | 0 |
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