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| 1 | Fatty liver is associated with an increased risk of diabetes and cardiovascular disease- Evidence from three different disease models: NAFLD, HCV and HIV显示文摘Fatty liver, which frequently coexists with necroinflammatory and fibrotic changes, may occur in the setting of nonalcoholic fatty liver disease(NAFLD) and chronic infections due to either hepatitis C virus(HCV) or human immunodeficiency virus(HIV). These three pathologic conditions are associated with an increased prevalence and incidence of cardiovascular disease(CVD) and type 2 diabetes(T2D). In this multidisciplinary clinical review, we aim to discuss the ever-expanding wealth of clinical and epidemiological evidence supporting a key role of fatty liver in the development of T2 D and CVD in patients with NAFLD and in those with HCV or HIV infections. For each of these three common diseases, the epidemiological features, pathophysiologic mechanisms and clinical implications of the presence of fatty liver in predicting the risk of incident T2 D and CVD are examined in depth. Collectively, the data discussed in this updated review, which follows an innovative comparative approach, further reinforce the conclusion that the presence of fatty/inflamed/fibrotic liver might be a shared important determinant for the development of T2 D and CVD in patients with NAFLD, HCV or HIV. This review may also open new avenues in the clinical and research arenas and paves the way for the planning of future, well-designed prospective and intervention studies. | Amedeo Lonardo Stefano Ballestri Giovanni Guaraldi Fabio Nascimbeni Dante Romagnoli Stefano Zona Giovanni Targher | 2016 | World Journal of Gastroenterology2016，22，44： | 4 |
| 2 | Prospective phase Ⅱ study of single-agent gemcitabine in untreated elderly patients with stage Ⅲ B/Ⅳ non-small cell lung cancer显示文摘 | Martoni A Di Fabio F Guaraldi M | 2001 | AM J Clin Oncol2001，24，6： | 1 |
| 3 | Severity of li- podystrophy is associated with decreased 'health -related quality of life 显示文摘 | Guaraldi G Murri R Orlando Gabriella | 2008 | AIDS Patient Care and STDs2008，22，7： | 1 |
| 4 | Glomerular filtration rates in HIV-infeeted patients treated with and without tenofovir: a prospective, observational study显示文摘 | Guaraldi G Roverato A Giovanardi C | 2009 | J Antimicrob Chemother2009，63，2： | 1 |
| 5 | Upregulation of nuclear-encoded mitochondrial LON protease in HAART-treated HIVpositive patients with lipodystrophy:immlications for the pathogenesis of the disease显示文摘 | Pinti M Gibellini L Guaraldi G | | 0，，06： | 1 |
| 6 | Lipodystrophy and quality of life of HIV - infected persons 显示文摘 | Guaraldi G Murri R Orlando G | 2008 | AIDS Rev2008，10，3： | 1 |
| 7 | Cushing syndrome:maybe not so uncommon of an endocrine disease显示文摘 | Guaraldi F Salvatori R | 2012 | J Am Board Fam Med2012，25，： | 1 |
| 8 | Nonalcoholic fatty liver disease in HIV-infected persons: epidemiology and the role of nucleoside reverse transcriptase inhibitors显示文摘 | Guaraldi G Stentarelli C Orlando G | 2010 | J Acquir Im- mune Defic Syndr2010，53，27： | 1 |
| 9 | High-dose epirubicin for untreated patients with advanced tumors: a phase Ⅰ study显示文摘 | MARTONI A MELOTTI B GUARALDI M | 1990 | Eur J Cancer1990，26，： | 1 |
| 10 | Cushing syndrome:maybe not so uncommon of an endocrine disease显示文摘 | Guaraldi F Salvatori R | | 0，，2： | 1 |
| 11 | Muhicenter randomised clinical trial on high-dose epirubicin plus cis-platinum versus vinorelbine pluse cis-platinum in advanced non small lung cancer 显示文摘 | Martoni A Guaraldi M Pina E | 1998 | Lung Cancer1998，22，： | 1 |
| 12 | Prospective phase II study of Single-agent gemcitabine in untreated elderly patients with stage IIIb/IV non-small cell lung cancer显示文摘 | Martoni A Di Fabio Guaraldi M | 2001 | Am J Clin Oncol2001，21，6： | 1 |
| 13 | Cushing syndrome:maybe not so uncommon of an endocrine disease显示文摘 | Guaraldi F Salvatori R | | 0，，02： | 1 |
| 14 | Mitochondrial complex III deficiency in a case of HCV related noninflammatory myopathy显示文摘 | P. Cortelli J. Mandrioli M. Zeviani R. Lodi C. Prata M. Pecorari G. Orlando G. Guaraldi | 2007 | Journal of Neurology2007，，10： | 1 |
| 15 | Cushing syndrome: maybe not so uncommon of an endocrine disease显示文摘 | Guaraldi F Salvatori R | 2012 | J Am Board Fam Med2012，25，2： | 1 |
| 16 | High dose epirubicin for untreated patients with advanced tumors: a phase Ⅰ study显示文摘 | MARTONI A MELOTTI B GUARALDI M et aI | 1990 | Eur J Cancer1990，26，： | 1 |
| 17 | lnvasive pulmonary and cerebral aspergillosis in a patient with Well's disease显示文摘 | Cocchi S Codeluppi M Guaraldi G | 2005 | Scand J Infect Dis2005，37，5： | 1 |
| 18 | Long-term psychometric outcomes of facial lipoatrophy therapy: forty-eight-week observational, nonrandomized study 显示文摘 | Orlando G Guaraldi G De Fazio D | 2007 | AIDS Patient Care STDS2007，21，11： | 1 |
| 19 | Prospective phase Ⅱ study of single agent gemcitabine in untreated elderly patients with stage Ⅲ B/1V non-small-cell lung cancer显示文摘 | Martoni A Di Fabio F Guaraldi M | 2001 | Am J Clin Oncol2001，24，6： | 1 |
| 20 | An Improved Multiple Scattering Model for Charged Particle Transport显示文摘 | Ferrari A Sala P R Guaraldi R | 1992 | Nucl Instr and Meth1992，71，： | 1 |
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