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| 1 | A novel human mAb (MERS-GD27) provides prophylactic and postexposure efficacy in MERS-CoV susceptible mice显示文摘Dear Editor,Since September 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) cases have been reported in more than 27 countries, and more than 2,000 cases have been confirmed in the laboratory (http://gffzz36b398b81f8a4a4chponwv0wbwwpq6ov9.ffgz.tsg.suse.edu.cn/emergencies/mers-cov/en/). MERS-CoV causes an acute and severe respiratory illness with a high mortality rate(~35%) in humans (Shi et al., 2017, Zaki et al., 2012).Neutralizing antibodies targeting the spike of MERS-CoV have been shown to be a therapeutic option for treatment of lethal disease (Agrawal et al., 2016, Ying et al., 2014). | Peihua Niu Guangyu Zhao Yao Deng Shihui Sun Wenling Wang Yusen Zhou Wenjie Tan | 2018 | Science China(Life Sciences)2018，61，10： | 11 |
| 2 | Two-photon-excited near-infrared emissive carbon dotsas multifunctional agents for fluorescence imaging andphotothermal therapy显示文摘C dots (CDs) have shown great potential in bioimaging and phototherapy.However, it is challenging to manipulate their fluorescent properties andtherapeutic efficacy to satisfy the requirements for clinic applications. In thisstudy, we prepared S, Se-codoped CDs via a hydrothermal method anddemonstrated that the doping resulted in excitation wavelength-independentnear-infrared (NIR) emissions of the CDs, with peaks at 731 and 820 nm.Significantly, the CDs exhibited a photothermal conversion efficiency of -58.2%,which is the highest reported value for C nanostructures and is comparable tothat of Au nanostructures. Moreover, the CDs had a large two-photon absorptioncross section (-30,045 GM), which allowed NIR emissions and the photothermalconversion of the CDs through the two-photon excitation (TPE) mechanism. Invitro and in vivo tests suggested that CDs can function as new multi functionalphototheranostic agents for the TPE fluorescence imaging and photothermaltheraov of cancer cells. | Minhuan Lan Shaojing Zhao Zhenyu Zhang Li Yan Liang Guo Guangle Niu Jinfeng Zhang Junfang Zhao Hongyan Zhang Pengfei Wang Guangyu Zhu Chun-Sing Lee Wenjun Zhang | 2017 | Nano Research2017，10，9： | 9 |
| 3 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 4 | Moisture-resistant,stretchable NO_(x)gas sensors based on laser-induced graphene for environmental monitoring and breath analysis显示文摘The accurate,continuous analysis of healthcare-relevant gases such as nitrogen oxides(NOx)in a humid environment remains elusive for low-cost,stretchable gas sensing devices.This study presents the design and demonstration of a moisture-resistant,stretchable NO_(x)gas sensor based on laser-induced graphene(LIG).Sandwiched between a soft elastomeric substrate and a moisture-resistant semipermeable encapsulant,the LIG sensing and electrode layer is first optimized by tuning laser processing parameters such as power,image density,and defocus distance.The gas sensor,using a needlelike LIG prepared with optimal laser processing parameters,exhibits a large response of 4.18%o ppm^(-1)to NO and 6.66%o ppm^(-1)to NO_(2),an ultralow detection limit of 8.3 ppb to NO and 4.0 ppb to NO_(2),fast response/recovery,and excellent selectivity.The design of a stretchable serpentine structure in the LIG electrode and strain isolation from the stiff island allows the gas sensor to be stretched by 30%.Combined with a moisture-resistant property against a relative humidity of 90%,the reported gas sensor has further been demonstrated to monitor the personal local environment during dfferent times of the day and analyze human breath samples to classify patients with respiratory diseases from healthy volunteers.Moisture-resistant,stretchable NO_(x)gas sensors can expand the capability of wearable devices to detect biomarkers from humans and exposed environments for early disease diagnostics. | Li Yang Guanghao Zheng Yaoqian Cao Chuizhou Meng Yuhang Li Huadong Ji Xue Chen Guangyu Niu Jiayi Yan Ye Xue Huanyu Cheng | 2022 | Microsystems & Nanoengineering2022，8，4： | 2 |
| 5 | Model division multiple access for semantic communications显示文摘In a multi-user system,system resources should be allocated to different users.In traditional communication systems,system resources generally include time,frequency,space,and power,so multiple access technologies such as time division multiple access(TDMA),frequency division multiple access(FDMA),space division multiple access(SDMA),code division multiple access(CDMA),and non-orthogonal multiple access(NOMA)are widely used.In semantic communication,which is considered a new paradigm of the next-generation communication system,we extract high-dimensional features from signal sources in a model-based artificial intelligence approach from a semantic perspective and construct a model information space for signal sources and channel features.From the high-dimensional semantic space,we excavate the shared and personalized information of semantic information and propose a novel multiple access technology,named model division multiple access(MDMA),which is based on the resource of the semantic domain.From the perspective of information theory,we prove that MDMA can attain more performance gains than traditional multiple access technologies.Simulation results show that MDMA saves more bandwidth resources than traditional multiple access technologies,and that MDMA has at least a 5-dB advantage over NOMA in the additive white Gaussian noise(AWGN)channel under the low signal-to-noise(SNR)condition. | Ping ZHANG Xiaodong XU Chen DONG Kai NIU Haotai LIANG Zijian LIANG Xiaoqi QIN Mengying SUN Hao CHEN Nan MA Wenjun XU Guangyu WANG Xiaofeng TAO | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，6： | 2 |
| 6 | Quantitative determination of free phytosterols in tobacco leaves by UPLC-MS/ MS显示文摘 | TAN Jianlin NIU Xuemei YANG Guangyu | 2013 | Journal of Liquid Chromatography and Related Technologies2013，36，5： | 1 |
| 7 | China Aerospace Academy of Systems Science and Engineering Established显示文摘On April 24,2016,the first National Day of Space Flight,China Aerospace Academy of Systems Science and Engineering(CAASSE)was officially established.Established from the former Beijing Institute of Information and Control and the Institute for Astronau- | NIU Guangyu | 2016 | Aerospace China2016，17，1： | 0 |
| 8 | Decorating ketjen black with ultra-small Mo_(2)C nanoparticles to enhance polysulfides chemisorption and redox kinetics for lithium-sulfur batteries显示文摘The low sulfur utilization and fast capacity fading resulting from the sluggish redox reaction and abominable polysulfides shuttle greatly hinder the practical applications of lithium-sulfur(Li-S) batteries.Herein, we develop a facile 'in-situ growth' method to decorate ultra-small Mo2 C nanoparticles(USMo2 C) on the surface of Ketjen Black(KB) to functionalize the commercial polypropylene(PP) separators,which can accelerate the redox kinetics of lithium polysulfides conversion and effectively increase the utilization of sulfur for Li-S batteries. Importantly, the US-Mo2 C nanoparticles have abundant sites for chemical adsorption towards polysulfides and the conductive carbon networks of KB have cross-linked pore channels, which can promote electron transport and provide physical barrier and volume expansion space for polysulfides. Due to the combined effects of the US-Mo2 C and KB, Li-S cells employing the multifunctional PP separators modified with KB/US-Mo2 C composite(KB/US-Mo2 C@PP) exhibit a high specific capacity(1212.8 mAh g^(-1) at 0.2 C), and maintain a reversible capacity of 1053.3 m Ah g^(-1) after 100 cycles.More importantly, the KB/US-Mo2 C@PP cells with higher sulfur mass loading of 4.9 mg cm^(-2) have superb areal capacity of 2.3 mAh cm^(-2). This work offers a novel and promising perspective for high-performance Li-S batteries from both the shuttle effect and the complex polysulfides conversion. | Nan Jiang Guangyu Jiang Dechao Niu Jiayi Mao Meiwan Chen Kaiyuan Li Yongsheng Li | 2020 | Journal of Energy Chemistry2020，29，12： | 0 |
| 9 | QIAN Xuesen Think Tank to Promote the Development of Xiong'an New District显示文摘The sixth QIAN Xuesen Forum'QIAN Xuesen Think Tank to Promote the Development of Xiong’an New District'was held in Beijing on April 23,2017 before the arrival of the second Space Day.Under the guidance of the Chinese Academy of Engineering(CAE),China Aerospace Science and Technology Corporation(CASC)and the preparatory work committee of Xiong’an New District,the forum was | NIU Guangyu WANG Deng | 2017 | Aerospace China2017，18，1： | 0 |
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