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| 1 | TDD-net: a tiny defect detection network for printed circuit boards显示文摘Tiny defect detection (TDD) which aims to perform the quality control of printed circuit boards (PCBs) is a basic and essential task in the production of most electronic products. Though significant progress has been made in PCB defect detection, traditional methods are still difficult to cope with the complex and diverse PCBs. To deal with these problems, this article proposes a tiny defect detection network (TDD-Net) to improve performance for PCB defect detection. In this method, the inherent multi-scale and pyramidal hierarchies of deep convolutional networks are exploited to construct feature pyramids. Compared with existing approaches, the TDD-Net has three novel changes. First, reasonable anchors are designed by using k-means clustering. Second, TDD-Net strengthens the relationship of feature maps from different levels and benefits from low-level structural information, which is suitable for tiny defect detection. Finally, considering the small and imbalance dataset, online hard example mining is adopted in the whole training phase in order to improve the quality of region-of-interest (ROI) proposals and make more effective use of data information. Quantitative results on the PCB defect dataset show that the proposed method has better portability and can achieve 98.90% mAP, which outperforms the state-of-arts. The code will be publicly available. | Runwei Ding Linhui Dai Guangpeng Li Hong Liu | 2019 | CAAI Transactions on Intelligence Technology2019，4，2： | 27 |
| 2 | Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique显示文摘Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases. | Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao Chen Mingyu Lei Wenbing Chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu | 2017 | Science China(Life Sciences)2017，60，3： | 14 |
| 3 | Adsorption characteristics of a novel ceramsite for heavy metal removal from stormwater runoff显示文摘Urban sediments have rapidly increased in recent years around the world,and their effective management has become an important problem.To remove heavy metals from stormwater runoff and use sediments as a resource,a novel ceramsite was developed using sewer pipe sediments(SPS),river bed sediments(RBS),urban water supply treatment sludge(WSTS),and wastewater treatment plant excess sludge(WWTS).The optimal composition was determined based on the Brunauer–Emmett–Teller specific surface area and an orthogonal test design.The adsorption characteristics of the novel ceramsite for dissolved heavy metals(Cu^(2+)and Cd^(2+)) were investigated through adsorption isotherms and kinetic experiments at(25±1)℃.Both Cu^(2+) and Cd^(2+) were effectively removed by the novel ceramsite,and their equilibrium adsorption was 4.96 mg·g^(-1) and 3.84 mg·g^(-1),respectively.Langmuir isotherms and a pseudo-first-order kinetic equation described the adsorption process better than other techniques.Characterization analysis of the ceramsite composition before and after heavy metal adsorption showed that the Cu^(2+) and Cd^(2+) contents in the ceramsite increased after adsorption.The results revealed that adsorption is both a physical and chemical process,and that ceramsite can be used as a bioretention medium to remove heavy metals from stormwater runoff while simultaneously converting problematic urban sediments into a resource. | Jianlong wang Yuanling Zhao Pingping Zhang Liqiong Yang Huai'ao Xu Guangpeng Xi | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 9 |
| 4 | Risk factors for pertussis among children hospitalized for pertussis during 2016-2017, in Guizhou Province of China: a case-control study显示文摘Aim:Pertussis is a respiratory tract infection,the vaccine for which was introduced in the Expanded Programme on Immunization(EPI)in Guizhou Province of China(hereafter referred as Guizhou)in the 1980s.This vaccine rapidly decreased incidence rates of pertussis in the province,however,despite the wide high coverage of the diphtheria,tetanus and acellular pertussis(DTaP)combined vaccine,there has been a resurgence of pertussis since 2014.Even with this recent increase in disease transmission,risk factors for pertussis infection have not been evaluated in Guizhou.We aimed to provide information on pertussis risk factors and insight on designing targeted pertussis control policies and measures through this study.Methods:A 1:2 matched retrospective case-control study was conducted between 2016 and 2017,involving infants and children younger than 6 years old and parents of the participants.The enrolled cases included clinical and laboratory confirmed pertussis cases according to the WHO-recommended pertussis definition.Controls were selected from children in the same neighborhood who were not diagnosed with pertussis prior to our investigation and did not exhibit any clinical manifestations of pertussis.Results:The household size[Matched odds ratio(OR_(m)=1.4,95%confidence interval(Cl):1.1-1.7]and household members with antecedent cough(OR_(m)=3.6,95%CI:1.8-7.2)were significantly associated with their child’s pertussis onset.The parents’occupations were significantly associated with their child’s pertussis onset(ORm=9.4,95%CI:1.6-54.8,for mother side;ORm=4.5,95%CI:1.2-16.5,for father side),when they worked in the business and/or service industry.Having family members with a history of cough was an independent risk factor for pertussis[Adjusted odds ratio(AOR)=43.6,95%CI:2.7-694.0].Besides,the parents’demographic characteristics and DTaP doses were not found to be independent factors.Conclusion:Household exposure is an important risk factor for pertussis infection in infants and young children and should therefore be considered as a major factor during formulation of pertussis control policies and measures. | Feng Jiang Keli Li Guangpeng Tang Yan Huang | 2021 | Global Health Journal2021，5，2： | 3 |
| 5 | Microsatellite DNA analysis proves nucleus of interspecies reconstructed blastocyst coming from that of donor giant panda显示文摘A method for DNA isolation from early development of blastocyst and further analysis of nuclear and mitochondrial DNA was developed in present study. Total DNA was prepared from interspecies reconstructed blastocyst and a giant panda specific microsatellite locus g010 was successfully amplified. DNA sequencing of the PCR product showed that two sequences of reconstructed blastocysts are the same as that of positive control giant panda. Our results prove that the nucleus of interspecies reconstructed blastocyst comes from somatic nucleus of donor giant panda. | DING Bo SHI Peng XIANGYU Jinggong ZHANG Yaping CHEN Dayuan SUN Qingyuan LI Guangpeng WANG Minkang LIU Yilong KANG Li HAN Zhiming SONG Xiangfen LI Jingsong CHEN Yuchun | 2000 | Chinese Science Bulletin2000，45，20： | 3 |
| 6 | Optimization of Technology for Increasing Total Ester Content of Jujube Wine by Adding Nutrients显示文摘Using jujube juice prepared from red jujube as raw material and Saccharomyces cerevisiae as experimental strain,the effect of nutrients on the content of total ester in jujube wine was studied. The nutrients affecting the total ester content of jujube wine were glutamine,arginine,calcium chloride and biotin by Plackett-Burman design. Through the steepest ascent test,it was determined that the central points of the optimum addition of nutrients were glutamine 40 mg/L,arginine 50 mg/L,calcium chloride 35 mg/L and biotin 0. 25 mg/L,respectively.Through Box-Behnken experiment design,taking glutamine,arginine,calcium chloride and biotin as experimental factors,and the content of total ester in jujube wine as response value,the response surface optimization experiment was carried out and the verification experiment was also carried out. It was found that the response surface model can be used to predict the total ester content of jujube wine when nutritional elements were added. When the content of total ester in jujube wine was the highest,the optimal combination of nutrients was glutamine38. 8 mg/L,arginine 53. 8 mg/L,calcium chloride 35. 7 mg/L and biotin 0. 3 mg/L. At this point,the content of total ester in jujube wine was 628 mg/L,which was very close to the predicted value. Through the sensory evaluation of jujube wine,it was found that adding nutrients could help to improve the taste of jujube wine,and the fermentation method of jujube wine by adding nutrients was simple and feasible. | Guangpeng LIU Fatao HE Yongbo DOU Fengtao ZHU Ling GAO Le CHU Yan ZHAO | 2019 | Asian Agricultural Research2019，11，5： | 2 |
| 7 | Effects of salinity on embryonic and larval development of Chinese mitten crab Eriocheir sinensis(Decapoda: Brachyura) and salinity-induced physiological changes显示文摘To investigate the effects of salinity on early development of Chinese mitten crab ( Eriocheir sinensis ), and the salinity tolerance mechanism of embryos, different developmental stages of embryos (gastrula, eyespot and pre-hatching stage), and hatched stage I zoea and megalopa, were exposed to a range of salinities (1, 5, 10, 15 (control), 20, 25, 30, 35 and 40). Hatching, survival and molting were monitored. Effects of 24-hour hypersaline (35) and hyposaline (1) stress on egg diameter, water content, Na +/K +-ATPase (NKA) activity, and crustacean hyperglycemic hormone (CHH) gene mRNA expression in embryos and megalopa, are reported. Embryos are more tolerant of low (≤ 5) than high (≥25) salinities, with optimum ranges for gastrula and pre-hatching stage embryos being 5-20, and for eyespot embryo and stage I zoea, 10-20. Most megalopa can molt to the first juvenile instar by day 5 at salinities between 1 and 40, whereas molting of megalopa stages was delayed at 40. Hypersaline conditions resulted in a loss of moisture, reduction of egg volume, and a signifi cant increase in NKA activity and CHH mRNA expression at some developmental stages. Hyposaline conditions did not affect moisture content or egg volume, but resulted in decreased NKA activity and CHH mRNA expression in embryos. For megalopa stages, NKA activity was significantly upregulated following both hypo- and hypersaline stress. Our results suggest high salinity will inhibit development and hatching of E. sinensis embryos, and low salinity will affect the survival of their stage I zoea. Increased NKA activity in embryos and megalopa stages might indicate a hyporegulation response under hypersaline conditions. These findings provide useful information for spawning ground protection of indigenous E . sinensis and enrich the knowledge of embryonic tolerance mechanisms of hyperregulating crustaceans following osmotic stress. | WANG Ruifang HUANG Xiaorong WANG Haihua LU Jianxue SHI Xiaotao FENG Guangpeng ZHUANG Ping | 2019 | Journal of Oceanology and Limnology2019，37，5： | 2 |
| 8 | Phenolic compounds and antioxidant capacities of bayberry juices显示文摘 | Zhongxiang Fang Yuhuan Zhang Yuan Lü Guangpeng Ma Jianchu Chen Donghong Liu Xingqian Ye | 2008 | Food Chemistry2008，，4： | 2 |
| 9 | Optimization of Fermentation Process of Carrot Juice by Probiotics and Analysis of Aroma Components显示文摘Carrot juice was fermented by probiotic Lactobacillus casei( CTCF-LC1) and Lactobacillus reuteri( CTCF-LT1) with sensory score as the main evaluation index,and the fermentation process was optimized by single factor and response surface experiments.The optimum ratio of fermentative strains CTCF-LC1∶ CTCF-LT1 was 1∶ 1,fermentation time was 8 h,inoculum size was 3.1% and fermentation temperature was26.6℃.Under the optimum conditions,the sensory score of fermented carrot juice was 91.3,pH was 4.50,total acid content was 3.73 g/L,total sugar content was 54.25 g/L,and reducing sugar content was 28.41 g/L.The carrot juice has bright orange color and stable state.It not only has the fresh flavor of fruit and vegetable juice,but also has the unique aroma from lactic acid bacteria fermentation,as well as soft and even taste,moderate acidity and sweetness.The changes of aroma components of carrot juice before and after fermentation were analyzed by headspace solid phase microextraction( HSPME) coupled with gas chromatography-mass spectrometry( GC-MS).After fermentation,substances with medicinal flavor components were reduced,and a lot of floral and fruit-scented substances were produced,such as methyl myristate,β-pinene,phenylethanol,and geraniol.Therefore,the results of this study can provide a theoretical basis for the development of fermented fruit and vegetable juice products with unique flavor substances. | Xiaotian LI Guangpeng LIU Jinglong LI Fengtao ZHU Bo ZHAO Yan ZHAO Fatao HE | 2019 | Asian Agricultural Research2019，11，1： | 2 |
| 10 | Comparative Study on Functional Properties of Mulberry Black Tea Fermented by Phellinus igniarius and Eurotium cristatum显示文摘[Objectives]To compare functional properties of mulberry black tea fermented by Phellinus igniarius and Eurotium cristatum.[Methods]The functional components of mulberry black tea fermented by P.igniarius and E.cristatum,the deep processing and health care effects of two probiotic fungi were explored.[Results]The polysaccharide content in the tea fermented by P.igniarius was the highest at 0.410 mg/mL,and the hydroxyl radical scavenging rate was the strongest,reaching 60.31%;the content of flavonoids in the tea fermented by E.cristatum was the highest,reaching 60.65μg/mL,and the content of polysaccharides was 83.17%higher than that of mulberry black tea,reaching 0.279 mg/mL.[Conclusions]The mulberry black tea fermented by P.igniarius and E.cristatum has improved in different functional components,and has its own advantages in aroma and mouthfeel,so it has certain research value and market prospect. | Yanrui MA Xuezhen LI Xuemei YANG Guangpeng LIU Le CHU Yan ZHAO Fatao HE | 2022 | Medicinal Plant2022，13，3： | 2 |
| 11 | Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-lH-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents显示文摘 | ZHANG Lan DENG Xinshan WU Jiaofeng MENG Guangpeng LIU Congchong CHEN Guzhou ZHAO Qingchun HU Chun | 2017 | Chemical Research in Chinese Universities2017，33，3： | 1 |
| 12 | Predicting dynamic behaviors of a whole machine tool structure based on computer-aided engineering显示文摘 | Zhang Guangpeng Huang Yumei Shi Wenhao | 2003 | In- ternational Journal of Machine Tools Manufacture2003，43，7： | 1 |
| 13 | Research on dynamic characteristics of assembled thin plates structure by BEM显示文摘 | FANG YingWu HUANG YuMei ZHANG GuangPeng | 2005 | Key Engineering Materials2005，，： | 1 |
| 14 | Experimental investigation of dynamic normal characteristics of machined joint surfaces显示文摘 | FU Weiping HUANG YuMei ZHANG GuangPeng | 2000 | Journal of Vibration and Acoustics2000，，10： | 1 |
| 15 | Towards Practical Application of Li-S Battery with High Sulfur Loading and Lean Electrolyte:Will Carbon-Based Hosts Win This Race?显示文摘As the need for high-energy–density batteries continues to grow, lithium-sulfur(Li–S) batteries have become a highly promising next-generation energy solution due to their low cost and exceptional energy density compared to commercially available Li-ion batteries. Research into carbon-based sulfur hosts for Li–S batteries has been ongoing for over two decades, leading to a significant number of publications and patents.However, the commercialization of Li–S batteries has yet to be realized. This can be attributed, in part, to the instability of the Li metal anode. However, even when considering just the cathode side, there is still no consensus on whether carbon-based hosts will prove to be the best sulfur hosts for the industrialization of Li–S batteries. Recently, there has been controversy surrounding the use of carbon-based materials as the ideal sulfur hosts for practical applications of Li–S batteries under high sulfur loading and lean electrolyte conditions. To address this question, it is important to review the results of research into carbon-based hosts, assess their strengths and weaknesses, and provide a clear perspective. This review systematically evaluates the merits and mechanisms of various strategies for developing carbon-based host materials for high sulfur loading and lean electrolyte conditions. The review covers structural design and functional optimization strategies in detail, providing a comprehensive understanding of the development of sulfur hosts. The review also describes the use of efficient machine learning methods for investigating Li–S batteries. Finally, the outlook section lists and discusses current trends, challenges, and uncertainties surrounding carbon-based hosts, and concludes by presenting our standpoint and perspective on the subject. | Yi Gong Jing Li Kai Yang Shaoyin Li Ming Xu Guangpeng Zhang Yan Shi Qiong Cai Huanxin Li Yunlong Zhao | 2023 | Nano-Micro Letters2023，15，9： | 1 |
| 16 | Application of Metabonomics in the Research of Lactic Acid Bacteria-fermented Foods显示文摘Lactic acid bacteria have been important industrial floras in the food fermentation production industry since ancient times.Their metabonomics technology has been widely used in the process monitoring,product classification and flavor formation mechanism of lactic acid bacteria-fermented foods.In this study,we discussed the application status of metabonomics technology in lactic acid bacteria-fermented food industry and scientific research,including dairy products,soy products,beverages and some pickled foods.Metabolomics will be applied in the research fields of lactic acid bacteria metabolism mechanism of lactic acid bacteria-fermented foods,lactic acid bacteria metabolomics database construction and expansion,metabolomics and genomics,and proteomics.In particular,the metabolomics technology will be introduced into product development and quality monitoring of traditional Chinese lactic acid bacteria-fermented foods,such as fermented bean curd and suancai,thereby perfecting industry norms and improving the level of industry development. | Guangpeng LIU Yanrui MA Le CHU Fengtao ZHU Yongbo DOU Jiwu WANG Fatao HE | 2021 | Agricultural Biotechnology2021，10，3： | 1 |
| 17 | Matrix attachment regions included in a bicistronic vector enhances and stabilizes follistatin gene expressions in both transgenic cells and transgenic mice显示文摘In the present study, follistatin(FST) gene expression vectors with either a bicistronic gene transfer cassette alone, or a bicistron gene cassette carrying a matrix attachment region(MAR) were constructed and transfected to bovine fetal fibroblasts. Evaluations of both the integration and expression of exogenous FST indicated that the p MAR-CAG-FST-IRES-Ac GFP1-poly A-MAR(pMAR-FST) vector had higher capacity to form monoclonal transgenic cells than the vector without MAR,though transient transfection and integration efficiency were similar with either construct. Remarkably, protein expression in transgenic cells with the p MAR-FST vector was significantly higher than that from the bicistronic vector. Exogenous FST was expressed in all of the p MARFST transgenic mice at F_0, F_1 and F_2. Total muscle growth in F_0 mice was significantly greater than in wild-type mice,with larger muscles in fore and hind limbs of transgenic mice. p MAR-FST transgenic mice were also found with more evenly distributed muscle bundles and thinner spaces between sarcolemma, which suggests a correlation between transgene expression-associated muscle development and the trend of muscle growth. In conclusion, a p MAR-FST vector, which excluded the resistant genes and frame structure, enhances and stabilizes FST gene expressions in both transfected cells and transgenic mice. | Xiaoming HU Jing GUO Chunling BAI Zhuying WEI Li GAO Tingmao HU Shorgan BOU Guangpeng LI | 2016 | Frontiers of Agricultural Science and Engineering2016，3，1： | 1 |
| 18 | Predicting dynamic behaviours of a whole machine tool structure based on computer-aided engineering显示文摘 | ZHANG Guangpeng HUANG Yumei SHI Wenhao | 2003 | International Journal of Machine Tools & Manufacture2003，43，7： | 1 |
| 19 | Experimental investigation on damping behavior of normal joint surfaces at unit area显示文摘 | FU Weiping HUANG Yumei ZHANG Guangpeng | 1993 | Modeling Measurement & Control B1993，51，2： | 1 |
| 20 | Predicting dynamic behavior of a whole machine tool structure based on computer-aided engineering显示文摘 | ZHANG Guangpeng HUANG Yumei SHI Wenhao | 2003 | International Journal of Machine Tools and Manufacture2003，43，： | 1 |
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