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| 1 | Olive oil consumption and non-alcoholic fatty liver disease显示文摘The clinical implications of non-alcoholic fatty liver diseases(NAFLD)derive from their potential to progress to fibrosis and cirrhosis.Inappropriate dietary fat intake,excessive intake of soft drinks,insulin resistance and increased oxidative stress results in increased free fatty acid delivery to the liver and increased hepatic triglyceride(TG)accumulation.An olive oil-rich diet decreases accumulation of TGs in the liver,improves postprandial TGs,glucose and glucagonlike peptide-1 responses in insulin-resistant subjects, and upregulates glucose transporter-2 expression in the liver.The principal mechanisms include:decreased nuclear factor-kappaB activation,decreased lowdensity lipoprotein oxidation,and improved insulin resistance by reduced production of inflammatory cytokines(tumor necrosis factor,interleukin-6)and improvement of jun N-terminal kinase-mediated phosphorylation of insulin receptor substrate-1.The beneficial effect of the Mediterranean diet is derived from monounsaturated fatty acids,mainly from olive oil.In this review,we describe the dietary sources of the monounsaturated fatty acids,the composition of olive oil,dietary fats and their relationship to insulin resistance and postprandial lipid and glucose responses in non-alcoholic steatohepatitis,clinical and experimental studies that assess the relationship between olive oil and NAFLD,and the mechanism by which olive oil ameliorates fatty liver,and we discuss future perspectives. | Nimer Assy Faris Nassar Gattas Nasser Maria Grosovski | 2009 | World Journal of Gastroenterology2009，15，15： | 22 |
| 2 | Lower baseline ALT cut-off values and HBV DNA levels better differentiate HBeAg(-) chronic hepatitis B patients from inactive chronic carriers显示文摘AIM:To determine whether new cut-off values for alanine aminotransferase(ALT)and baseline hepatitis B virus(HBV)DNA levels better differentiate HBeAg(-) chronic hepatitis B(CHB)patients from inactive chronic carriers. METHODS:Ninety-one patients[32 HBeAg(+)CHB, 19 inactive carriers and 40 HBeAg(-)CHB]were followed up for 2 years and were tested for HBV DNA levels by a PCR-based assay.ALT was tested twice during the last 6 mo using new cut-off values:ULN(upper limit of normal)30 IU/L for males,19 IU/L for females. Diagnostic accuracy,sensitivity,specificity,positive and negative predictive values were calculated by discriminant analysis. RESULTS:When using the revised ALT cut-off values, the lowest optimal HBV DNA level that differentiated HBeAg(-)CHB patients from inactive carriers was 50000 copies/mL.The diagnostic accuracy of HBV DNA to determine inactive carriers with a cut-off of 50000 copies/mL was similar to the previously recommended cut-off of 100 000 copies/mL(91%).HBV DNA levels were lower than the cut-off value in 95%of inactive carriers and in 28%of HBeAg(-)CHB patients.With ALT<30 IU/L in men and<19 IU/L in women and HBV DNA levels<100 000 copies/mL,the risk of CHB is 5%.On the other hand,if ALT values were>30 IU in men and>19 IU in women and baseline HBV DNA levels were>100000 copies/mL,the risk is 86%. CONCLUSION:New cut-off values for ALT together with HBV DNA levels proposed by AASLD(American Association for the Study of Liver Diseases)and NIH (National Institute of Health)consensus seem appropriate to characterize inactive carriers. | Nimer Assy Zaza Beniashvili Agness Djibre Gattas Nasser Maria Grosovski William Nseir | 2009 | World Journal of Gastroenterology2009，15，24： | 7 |
| 3 | Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats显示文摘AIM: To evaluate the effects of different types of dietary fats on the hepatic lipid content and oxidative stress parameters in rat liver with experimental non-alcoholic fatty liver disease (NAFLD). METHODS: A total of 32 Sprague-Dawley rats were randomly divided into fi ve groups. The rats in the control group (n = 8) were on chow diet (Group 1), rats (n = 6) on methionine choline-defi cient diet (MCDD) (Group 2), rats (n = 6) on MCDD enriched with olive oil (Group 3), rats (n = 6) on MCDD with fish oil (Group 4) and rats (n = 6) on MCDD with butter fat (Group 5). After 2 mo, blood and liver sections were examined for lipids composition and oxidative stress parameters.RESULTS: The liver weight/rat weight ratio increased in all treatment groups as compared with the control group. Severe fatty liver was seen in MCDD + fish oil and in MCDD + butter fat groups, but not in MCDD and MCDD + olive oil groups. The increase in hepatic triglycerides (TG) levels was blunted by 30% in MCDD + olive oil group (0.59 ± 0.09) compared with MCDD group (0.85 ± 0.04, P < 0.004), by 37% compared with MCDD + fi sh oil group (0.95 ± 0.07, P < 0.001), and by 33% compared with MCDD + butter group (0.09 ± 0.1, P < 0.01). The increase in serum TG was lowered by 10% in MCDD + olive oil group (0.9 ± 0.07) compared with MCDD group (1.05 ± 0.06). Hepatic cholesterol increased by 15-fold in MCDD group [(0.08 ± 0.02, this increment was blunted by 21% in MCDD + f ish oil group (0.09 ± 0.02)]. In comparison with the control group, ratio of long-chain polyunsaturated fatty acids omega-6/ | Osamah Hussein Masha Grosovski Etti Lasri Sergio Svalb Uzi Ravid Nimer Assy | 2007 | World Journal of Gastroenterology2007，13，3： | 3 |
| 4 | Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome显示文摘 | Ali Abid Ola Taha William Nseir Raymond Farah Maria Grosovski Nimer Assy | 2009 | Journal of Hepatology2009，，5： | 1 |
| 5 | Isolation of an APRT heterozygote from TK6 human lymphoblasts显示文摘 | Pongsaensook P Smith L E Grosovsky A J | 1997 | Mutat Res1997，377，1： | 1 |
| 6 | Radiation-induce Mutations in Unirradiated DNA显示文摘 | GROSOVSKY A J | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 7 | Radiation-induce mutations in unirradiated DNA 显示文摘 | Grosovsky A J | 1999 | Proc Natl Acad Sci USA1999，，96： | 1 |
| 8 | Radiation-induced mutations in unirradiated DNA 显示文摘 | Grosovsky A | 1999 | proc Natl Acad Sci USA1999，96，10： | 1 |
| 9 | Orlistat reverse fatty infiltration and improves hepatic fibrosis in obese patients with nonalcoholic steatohepatitis(NASH)显示文摘 | Hussein O Grosovski M Schlesinger S | 2007 | Dig Dis Sci2007，52，10： | 1 |
| 10 | Radiation-induced mutations in unirradiated DNA 显示文摘 | Grosovsky A | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
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