|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted. | Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh | 2015 | World Journal of Clinical Oncology2015，6，5： | 4 |
| 2 | Magnetic and crystallographic properties of several C1b type Heusler compounds 显示文摘 | Helmholdt R B de Groot R A Mueller F M | 1984 | J Magn Magn Mater1984，43，： | 2 |
| 3 | B-type natriuretic peptide and peak exercise oxygen consumption provide independent information for risk stratification in patients with stable congestive heart failure 显示文摘 | de Groote P Dagorn J Soudan B | 2004 | J Am Coll Cardiol2004，43，9： | 1 |
| 4 | The effect of estrogen receptor genotype on litter size and placental traits at term in F2 crossbred gilts 显示文摘 | Van Rens B T de Groot P N Van Der L T | 2002 | Theriogenology2002，57，6： | 1 |
| 5 | Effects of manganese oxide promoter on the CO and H2adsorption properties of titania-supported cobalt Fischer-Tropsch catalysts显示文摘 | MORALES F SMIT E GROOT F M F VISSER T WECKHUYSEN B M | 2007 | J Catal2007，246，1： | 1 |
| 6 | Seismic inversion successfully predicts reservoir, porosity, and gas content in Ibhubesi Field, Orange Basin, South Africa 显示文摘 | Berge T B Fred Aminzadeh Paul de Groot | 2002 | The Leading Edge2002，21，4： | 1 |
| 7 | Simultaneous detection of NOS-3 protein expression and nitric oxide production using a flow cytometer显示文摘 | Havenga MJE VanDam B Groot BS | 2001 | Analytical Biochemistry2001，290，2： | 1 |
| 8 | Structure and function of water channels显示文摘 | Fujiyoshi Y Mitsuoka K de Groot B L | 2002 | Curr Opin Struct Biol2002，12，4： | 1 |
| 9 | Dissipative particle dy- namics:bridging the gap between atomistic and meso- scopic simulation显示文摘 | GROOT R D WARREN P B | 1997 | J Chem Phys1997，107，11： | 1 |
| 10 | Non-islet cell tumour-in- duced hypoglycaemia: a review of the literature including two new cases 显示文摘 | Groot JW Rikhof B van Doom J | 2007 | Endocr Relat Cancer2007，14，4： | 1 |
| 11 | Water permeation across biological membranes: mechanism and dynamics of aqua- porirrl and GlpF显示文摘 | de Groot B L Grubmtiller H | 2001 | Science2001，294，： | 1 |
| 12 | Autoantibodies directed against domain Iof beta2-glycoprotein I 显示文摘 | de Laat B de Groot PG | 2011 | Curr Rheumatol Rep2011，13，1： | 1 |
| 13 | The consistency of large concerted motions in proteins in molecular dynamics simulations显示文摘 | de Groot B L van Aalten D M Amadei A | 1996 | Biophys J1996，71，4： | 1 |
| 14 | A quantum chemical explanation of the antioxidant activity of flavonoids显示文摘 | SASKIA A B E VAN ACKER MARCEL J DE GROOT el al | 1996 | Chem Res Toxicol1996，9，： | 1 |
| 15 | Non-islet cell tumor-induced hypoglycemia: a review of the literature including two new cases显示文摘 | de GROOT JWB RIKHOF B van DOORN J | 2007 | Ehdocr Relat Cancer2007，14，4： | 1 |
| 16 | Dissipative particle dynamics:Bridging the gap between atomistic and mesoscopic simulation显示文摘 | Groot R D Warren P B J | 1997 | Chem Phys1997，107，11： | 1 |
| 17 | Identifying fault and gas chimneys using multi-attributes and neural networks 显示文摘 | Meldahl P R Heggland B Bril and P de Groot | 2001 | The Leading Edge2001，20，5： | 1 |
| 18 | The Value of the World's Ecosystem Services and Natural Capital显示文摘 | Costanza R d'Arge R de Groot R Farberk S Grasso M Hannon B Limburg K Naeem S O'Neill R V Paruelo J Raskin R G Suttonkk P van den Belt M | | 0，，6630： | 1 |
| 19 | The association between sports participation, alcohol use and aggression violence: A systematic review显示文摘 | Snderlund A O' Brien K Kremer P Rowland B De Groot F Stalger P Zinkiewicz L Miller P | 2014 | Journal of Science & Medicine in Sport2014，17，1： | 1 |
| 20 | Lupus anticoagu-lants and the risk of a first episode of deep venous thrombosis 显示文摘 | DE GROOT PG LUTTERS B DERKSEN RH | 2005 | JThromb Haemost2005，3，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员