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| 1 | Oxidative Stress, Biochemical and Histopathological Alterations in the Liver and Kidney of Female Rats Exposed to Low Doses of Deltamethrin (DM):A Molecular Assessment显示文摘Objective To evaluate histopathological alterations of the liver and kidney of female rats exposed to low doses of DM and its potential genotoxic activity. Methods Female Wistar rats were randomly assigned to control (3 groups, 6 rats in each) and treatment groups (3 groups, 6 rats in each). They were subjected to subcutaneous injections of DM (at doses of 0.003, 0.03, and 0.3 mg/kg bw/d) after 30, 45, and 60 d, respectively. Results Significant alterations were recorded in liver parenchyma induced by hepatic vacuolization, fragmented chromatin in nuclei, dilatation of sinusoids and congestions. Lesions within proximal and distal tubules were observed in the kidneys. Tissue congestions and severe alterations within glomeruli were visible. DM as a pyrethroid insecticide induced significant increase (P≤0.05) of plasma MDA concentrations after 45 d. A significant increase (P≤0.05) in plasma ALT (after 45 and 60 d) and AST (after 60 d) concentrations was recorded as compared to controls. During the whole experimental period the toxic agent provoked significant DNA damages (P≤0.05), especially in the dominance of classes 3 and 4 of obtained comet. Conclusion DM even at a very low dose displays harmful effects by disrupting hepatic and renal function and causing DNA damages in puberscent female rats. Low doses of DM are hepatotoxic and nephrotoxic. | CHARGUI Issam GRISSA Intissar BENSASSI Fatma HRIRA Mohamed Yahia HAOUEM Samir HAOUAS Zohra BENCHEIKH Hassen | 2012 | Biomedical and Environmental Sciences2012，25，6： | 2 |
| 2 | Effects of olive oil and its frac- tions on oxidative stress and the liver's fatty acid composition in 2, 4-Dichlorophenoxyacetic acid- treated rats 显示文摘 | Nakbi A Tayeb W Grissa A | 2010 | Nutr Metab (Lond)2010，7，： | 1 |
| 3 | The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats 显示文摘 | Grissa I Vergnaud G Pourcel C | 2007 | BMC Bioinformatics2007，8，1： | 1 |
| 4 | Protective effect of resveratrol on ethanol - induced lipid peroxidation in rats 显示文摘 | Kasdallah - Grissa A Mornagui B Aouani E | 2006 | Alcohol Alcohol2006，41，3： | 1 |
| 5 | The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats 显示文摘 | Grissa I Vergnaud G Pourel C | 2007 | BMC Bioinform2007，8，1： | 1 |
| 6 | Modulation of adipokines and cytoldnes in gestafional diabetes and macrosomia显示文摘 | Ategbo J M Grissa O Yessoufou A | 2006 | J Clin Endocrinol Metab2006，91，10： | 1 |
| 7 | CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats显示文摘 | Grissa I Vergnaud G Pourcel C | 2007 | Nucleic Acids Research2007，35，： | 1 |
| 8 | The CRISPRdb data- base and tools to display CRISPRs and to generate dic- tionaries of spacers and repeats 显示文摘 | Grissa I Vergnaud G Pourcel C | 2007 | BMC Bioinformat- ics2007，8，： | 1 |
| 9 | Modulation of adipokines and cytokines in gestational diabetes and macrosomia显示文摘 | Ategbo JM Grissa O Yessoufou A | 2006 | J Clin Endocrinol Metab2006，91，10： | 1 |
| 10 | Modulation of Adipokines and Cyto Kines in Gestational Diabetes and Macrosomia显示文摘 | J-M Ategbo O Grissa A Yessoufou | | 0，，10： | 1 |
| 11 | Modulation of adipokines and cytokines in gestational diabetes and macrosomia显示文摘 | Ategbo JM Grissa O Yessoufou A | 2006 | J Clin Endocrinol Metab2006，91，10： | 1 |
| 12 | Magnesium sulfate versus ipratropium bromide in chronic obstructive pulmonary disease exacerbation: a randomized trial显示文摘 | Nouira S Bouida W Grissa MH | 2014 | American journal of therapeutics2014，21，3： | 1 |
| 13 | The CPdSPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and re- peats 显示文摘 | GRISSA I VERGNAUD G POURCEL C | 2007 | BMC Bioinformatics2007，8，： | 1 |
| 14 | The CRISPR database and tools to display CRISPRs and to generate dictionaries of spacers and repeats 显示文摘 | GRISSA I VERGNAUD G POURCEL C | 2007 | BMC Bioinfonnatics2007，8，： | 1 |
| 15 | Antioxidant status and circulating lipids are altered in human gestational diabetes and macrosomia 显示文摘 | Grissa O Ategbo JM Yessoufou A | 2007 | Translat Res2007，150，3： | 1 |
| 16 | Antioxidant status and circulating lipids are altered in human gestational diabetes and macrosomia 显示文摘 | Grissa O Ategbo JM Yessoufou A | 2007 | Transl Res2007，150，5： | 1 |
| 17 | The CRISPR databaseand tools to display CRISPRs and to generate dictionaries of spacer-sand repeats显示文摘 | GRISSA I VERGNAUD G POURCEL C | 2007 | BMC Bioinfoimatics2007，8，： | 1 |
| 18 | Modulation ofadipokines and cytokines in gestational diabetes and macrosomia显示文摘 | Ateqbo JM Grissa O Yessoufou A | 2006 | J Clin Endocrinol Metab2006，91，10： | 1 |
| 19 | CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats 显示文摘 | Grissa I Vergnaud G Pourcel C | 2007 | Nucleic acids research2007，35，2： | 1 |
| 20 | Growth factor concentrations and their placental mRNA expression are modulated in gestational diabetes mellitus: possible interactions with maerosomia 显示文摘 | Grissa O Yessoufou A Mrisak I | 2010 | BMC Pregnancy Childbirth2010，10，： | 1 |
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