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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | Terminal guidance for impact attitude angle constrained flight trajectories 显示文摘 | Kim M Grider K V | 1973 | IEEE Transaction on Aerospace and Electronic System1973，9，6： | 1 |
| 3 | Propulsion in guinea-pig colon induced by 5-HT Via 5-HT4 and 5-HT3 receptors显示文摘 | Jin JG Foxx-Orenstein AE Grider JR | 1999 | Pharmacol Exp Ther1999，288，1： | 1 |
| 4 | Neurotransmitters mediating the intestinal peristaltic reflex in the mouse显示文摘 | Grider J R | 2003 | J Pharmacol Exp Ther2003，307，： | 1 |
| 5 | 5 - Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine 显示文摘 | Grider JR Foxx - Orenstein AE Jin JG | 1999 | Gastroenterologry1999，115，： | 1 |
| 6 | Terminal guidance for impact attitude angle constrained flight trajectories 显示文摘 | Kim M Grider K V | 1973 | IEEE Transactions on Aerospace and Electronic Systems1973，9，6： | 1 |
| 7 | h randomized double-blind trial comparing continuous thoracic epidural bupivacaine with and without opioid in contrast to a continuous paravertebral infusion of bupivacaine for post-thoracotomy pain显示文摘 | Grider JS Mullet TW Saha SP | 2012 | J Cardiothorac Vasc hnesth2012，26，1： | 1 |
| 8 | Lipid raft - targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac 1, respectively 显示文摘 | Grider MH Park D Spencer DM | 2009 | J Neurosci Res2009，87，14： | 1 |
| 9 | Age-dependent influence of dietary zinc restriction on short-term memory in male rats显示文摘 | Keller K A Grider A Coffield J A | 2001 | Physiol Behav2001，72，3： | 1 |
| 10 | Perioperative management of patients with an intrathecal drug delivery system for chronic pain 显示文摘 | Grider J Brown R Colclough G | 2008 | Anaesth Anal2008，107，4： | 1 |
| 11 | Autoinhibition of endothelial nitric oxide synthase (eNOS) in gut smooth muscle by nitric oxide显示文摘 | John R. Grider Karnam S. Murthy | 2008 | Regulatory Peptides2008，，1： | 1 |
| 12 | Charac- terization of PAPCAP receptors and signaling path- ways in rabbit gastric muscle cells显示文摘 | JIN J G MURTHY K S GRIDER I R | 1997 | Am G Physiol1997，272，： | 1 |
| 13 | Brain-derived neurotrophic factor augments peristalsis by augmenting 5-HT and calcitonin gene-related peptide release 显示文摘 | Grider JR Piland BE Gulick MA | 2006 | Gas- troenterology2006，130，3： | 1 |
| 14 | Interplay of somatostatin,opioid,and GABA neurons in the regulation of the peristaltic reflex显示文摘 | Grider JR | | 0，，04： | 1 |
| 15 | Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis 显示文摘 | Grider J R | 1993 | Am J Physiol1993，264，： | 1 |
| 16 | Terminal guidance for impact attitude angle constrained flight trajectories 显示文摘 | Kim M Grider K V | 1973 | IEEE Transactions on Aerospace and Electronic Systems1973，9，6： | 1 |
| 17 | Mechanism of atrial natriuretic peptide release with increased inspiratory resitsance显示文摘 | Lee LY Grider J | 1996 | J Lab Clin Med1996，128，3： | 1 |
| 18 | Terminal Guidance for Impact Attitude Angle Constrained Flight Trajectories 显示文摘 | Kim M Grider K V | 1973 | IEEE Transactions on Aerospace and Electronic Systems1973，9，6： | 1 |
| 19 | Telormeres,telomerase and cancer显示文摘 | Grider CW Blackburn HE | 1996 | Scientific Am1996，274，： | 1 |
| 20 | Terminal guidance for impact attitude angle constrained flight trajectories 显示文摘 | Kim M Grider K V | 1973 | IEEE Transactions on Aerospace and Electronic Systems1973，9，6： | 1 |
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