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| 1 | Clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis显示文摘AIM To assess differences in clinical outcomes of isolated renal failure(RF) compared to other forms of organ failure(OF) in patients with severe acute pancreatitis(SAP).METHODS Using a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ(2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded. Differences in clinical outcomes after development of isolated RF in comparison to other forms of OF were determined using independent t and Mann-Whitney U tests for continues variables, and χ~2 test for discrete variables.RESULTS Among 500 patients with acute pancreatitis, 111 patients developed persistent OF: mean age was 54 years, and 75(67.6%) were male. Forty-three patients had isolated OF: 17(15.3%) renal, 25(21.6%) respiratory, and 1(0.9%) patient with cardiovascular failure. No differences in demographics, etiology of acute pancreatitis, systemic inflammatory response syndrome scores, or development of pancreatic necrosis were seen between patients with isolated RF vs isolated respiratory failure. Patients with isolated RF were less likely to require nutritional support(76.5% vs 96%, P = 0.001), ICU admission(58.8% vs 100%, P = 0.001), and had shorter mean ICU stay(2.4 d vs 15.7 d, P < 0.001), compared to isolated respiratory failure. None of the patients with isolated RF or isolated respiratory failure died.CONCLUSION Among patients with SAP per the Revised Atlanta Classification, approximately 15% develop isolated RF. This subgroup seems to have a less protracted clinical course compared to other forms of OF. Isolated RF might be weighed less than isolated respiratory failure in risk predictive modeling of acute pancreatitis. | Amir Gougol Mohannad Dugum Anwar Dudekula Phil Greer Adam Slivka David C Whitcomb Dhiraj Yadav Georgios I Papachristou | 2017 | World Journal of Gastroenterology2017，23，29： | 20 |
| 2 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 3 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 4 | Size Dependence of Mechan- ical Properties of Gold at the Micron Scale in the Absence of Strain Gradients显示文摘 | Greer J R Oliver W C Nix W D | 2005 | Acta Materialia2005，53，6： | 1 |
| 5 | Infant gastroesophageal reflux information on the World Wide Web显示文摘 | Balgowan R Greer L C D'Auria J P | 2016 | J Pediatr Health Care2016，30，2： | 1 |
| 6 | The aerobic growth of Aeromonas hydrophila and Listeria monocytogenes in broths and on pork显示文摘 | GILL C O GREER G G DILTS B D | 1997 | Int J Food Microbiol1997，35，： | 1 |
| 7 | Phase Ⅰ/Ⅱ trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia显示文摘 | List AF Spier C Greer John | 1993 | J Clin Oncol1993，11，9： | 1 |
| 8 | Biodegradation of pe- troleum hydrocarbon by psychrotrophic Pseudomonas strains possessing both alkane (alk) and naphthalene (nah) catabolic pathways 显示文摘 | Whyte L Bourbonniere L Greer C W | 1997 | Appl Environ Mierobiol1997，63，9： | 1 |
| 9 | Role of laminin in axonal extension from olfactory receptor cells显示文摘 | Greer C A | 1997 | J Neurobiol1997，32，： | 1 |
| 10 | Considering Diversity: The Positive Effects of Considerate Leadership in Diverse Teams 显示文摘 | Homan A C Greer L L | 2013 | Group Processes & Intergroup Relations2013，16，1： | 1 |
| 11 | Low-molecular-weight heparins for threm- boprophylaxis and treatment of venous thremboembolism in pregnan- cy: a systematic review of safety and efficacy 显示文摘 | Greer IA Nelson-Pierey C | 2005 | Blood2005，106，2： | 1 |
| 12 | Comparison of two methods for anteriorposterior isocenter localization in pelvic radiotherapy using electronic portal imaging显示文摘 | Greer P B Mortensen T M Jose C C | 1998 | Int J Radiat Oncol Biol Phys1998，41，： | 1 |
| 13 | Phase Ⅰ/Ⅱ trial of Cyclosporine as a chemotherapy resistance modifier in acute leukemia显示文摘 | List AF Spier C Greer J | 1993 | J Clin Oncol1993，11，： | 1 |
| 14 | Low - molecular - weight heparins for thromboprophylaxis and treatment of venous thromboembofism in pregnancy: a systematic review of safety and efficacy 显示文摘 | Greer IA Nelson - Piercy C | 2005 | Blood2005，106，： | 1 |
| 15 | Understanding health literacy: an expanded model显示文摘 | ZARCADOOLAS C PLEASANT A GREER DS | 2005 | Health Promot Int2005，20，2： | 1 |
| 16 | Phase Ⅰ/Ⅱ trial of cyclosporine as a chemotherapy resistance modifier in acute leukaemia显示文摘 | Spier C Greer J | 1993 | J Clin Oncol1993，11，9： | 1 |
| 17 | A Likely Mechanism for Pitch Deposition Control 显示文摘 | Shetty C S Greer C S Laubach G D | 1994 | Tappi Journal1994，77，10： | 1 |
| 18 | The occurrence of endosperm cells in wheat flour显示文摘 | Greer E N Hinton J J C Jones C R | 1951 | Cereal Chem1951，28，： | 1 |
| 19 | Biodegradation of petroleum hydrocarbons by psychrotrophic Pseudomonas strains possessing both alkane(alk) and naphthalene(nah) catabolic pathways显示文摘 | Whyte L C Bourbonniere L Greer C W | 1997 | Applied and Environmental Microbiology1997，63，： | 1 |
| 20 | Microbial functional potential and community composition in permafrost-affected soils of the NW Canadian Arctic显示文摘 | FRANK-FAHLE B A YERGEAU E GREER C W | 2014 | The Public Library of Science2014，9，84： | 1 |
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