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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Rough sets theory for multicriteria decision analysis显示文摘 | GRECO S MATARAZZO B SLOWINSKI R | 2001 | European Journal of Operational Research2001，129，1： | 1 |
| 3 | Corrosin of Iron in an H2S- CO2-H20 System显示文摘 | Greco Edward C William B Wright | 1962 | Corrosion1962，18，： | 1 |
| 4 | Rough sets methodology for sorting problems in presence of multiple attributes and criteria显示文摘 | Greco S Matarazzo B Slowinski R | 2002 | European J of Operational Research2002，138，2： | 1 |
| 5 | Renal artery stenosis:prevalenceof,risk factors for,and management of in-stent stenosis显示文摘 | Boateng F K Greco B A | 2013 | Am J Kidney Dis2013，61，1： | 1 |
| 6 | Corrosion of iron in an H2 S - CO2 - H20 system: Corrosion filrm properties on pure iron 显示文摘 | ASardisco J B Wright W B Greco E C | 1963 | Corrosion1963，19，10： | 1 |
| 7 | The contribution of water hyacinth ( Eichhornia erassipes) and zooplankton to the internal cycling of Phosphorus in the eutrophic Pampulba Reservoir 显示文摘 | Pinto-Coelho R M Greco M K B | 1999 | Brazil Hydrobiologia1999，411，： | 1 |
| 8 | Estrogen receptor beta messenger ribonucleic acid expression in the forebrain of proestrous,pregnant,and lactating female fats 显示文摘 | Greco B Lubbers LS Blaustein JD | 2003 | Endocrinology2003，144，5： | 1 |
| 9 | Rough Approximation of Preference Relation by Dominance Relations显示文摘 | Grecos Matarazzo B Slowinski R | 1999 | European Journal of Operational Research1999，117，1： | 1 |
| 10 | Rough approximation by dominance relations显示文摘 | Greco S Matarazzo B Slowinski R | 2002 | International Journal of Intelligent Systems2002，，17： | 1 |
| 11 | Intergeneric wheat x barley hybrid 显示文摘 | Blanco A Fracchiolla G V Greco B | 1986 | J Hered1986，77，： | 1 |
| 12 | RE-l-silen- cing transcription factor shows tumor-suppressor func- tions and negatively regulates the oncogenic TAC1 in breast cancer cells 显示文摘 | Reddy B Y Greco S J Patel P S | 2009 | Proc Natl Acad Sci U S A2009，106，11： | 1 |
| 13 | Importance of cyclophoephamide-induced bystander effect on T cells for a successful tumor eradication in response to adoptive immunotherapy in mice 显示文摘 | Pmietti E Greco G Garrone B | 1998 | J Clin Invest1998，101，2： | 1 |
| 14 | Rough sets theory for multi-criteria decision analysis显示文摘 | Greco S Matarazzo B Slowinski R | 2001 | European Journal of Operational Research2001，129，1： | 1 |
| 15 | Rough set theory for multicriteria decision analysis显示文摘 | Greco S Matarazzo B Slowinski R | | 0，，： | 1 |
| 16 | Rough approximation by dominance relations显示文摘 | Greco S Matarazzo B Slowinski R | | 0，，02： | 1 |
| 17 | Rough approximation by dominance relations显示文摘 | GRECO S MATARAZZO B SLOWINSKI R | 2002 | International Journal of Intelli- gent Systems2002，17，2： | 1 |
| 18 | Rough sets theory for multicriteria decision analysis显示文摘 | Greco S Matarazzo B Slowinski R | 2001 | European Journal of Operational Research2001，129，： | 1 |
| 19 | Transpositional behaviour of an Ac/Ds system for revere genetics in rice显示文摘 | Ouwerkerk P B De Kam R J | 2003 | Theor Appl Genet2003，108，1： | 1 |
| 20 | Importance of cyclophosphamide-indueed bystander effect on T cells for a successful tumor eradication in response to adoptive immunotherapy in mice显示文摘 | Proietti E Greco G Garrone B | 1998 | J ClinInvest1998，101，2： | 1 |
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