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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | In vivo cultivation of human articular chondrocytes in a nude mouse-based contained defect organ culture model显示文摘 | Mueller-Rath R Gavé nis K Gravius S | | 0，，06： | 1 |
| 3 | Lack of effect on bone healing of injectable BMP-2 augmented hyaluronic acid显示文摘 | Maus U Andereya S Gravius S | 2008 | Arch Orthop Trauma Surg2008，128，12： | 1 |
| 4 | Operative treatment of congenital hip osteoarthritis with high hip luxation(Crowe type Ⅳ)显示文摘 | Kohlhof H Ziebarth K Gravius S | 2013 | Oper Orthop Traumatol2013，25，5： | 1 |
| 5 | Pelvic osseous infections: clinical outcome and surgical treatment 显示文摘 | Weber O Gravius S Henkel S | 2008 | Z Orthop Unfall2008，146，4： | 1 |
| 6 | Expression of CalfProchymosin in Saccharomyces Cerevisae, Gene 显示文摘 | Goffer CG Moir DT Gravius TC | 1984 | 27 ( 1 ) : 35 -461984，27，1： | 1 |
| 7 | Pelvic osseous infections : clinical outcome and surgical treatment 显示文摘 | WEBER O GRAVIUS S HENKEL S | 2008 | Z Orthop Unfall2008，146，4： | 1 |
| 8 | BMP-2 incorporated in a triealeium phosphate bone substitute enhances bone remodeling in sheep 显示文摘 | Maus U Andereya S Gravius S | 2008 | Biomater Appl2008，22，6： | 1 |
| 9 | Genetic instability and strain degeneration in Streptomyces rimosus 显示文摘 | Gravius B Bezmalinovic T Hranueli D | 1993 | Appl Environ M icrobiol1993，59，7： | 1 |
| 10 | Genetic instability and strain degeneration in Streptomyces rimosus 显示文摘 | Gravius B Bezmalinovic T Hranueli D | 1993 | Appl Environ Microbiol1993，59，7： | 1 |
| 11 | Genetic instability and strain degeneration in Streptomyces rimosus 显示文摘 | Gravius B Bezmalinovic T I-Iranueli D | 1993 | Appl Environ Microbiol1993，59，7： | 1 |
| 12 | Mechanical in vitro testing of fifteen commercial bone cements based on polymethylmethacrylate显示文摘 | Gravius S Wirtz D C Marx R | 2007 | Orthop Unfall2007，145，5： | 1 |
| 13 | The 387 kb linear plasmid pPZG101 of Streptomyces rimosus and its interactions with the chromosome显示文摘 | GRAVIUS B GLOCKER D PIGAC J | 1994 | Microbiology1994，140，9： | 1 |
| 14 | Biological acetabular defect reconstruction in revision hip arthroplasty using impaction bone grafting and an acetabular reconstruction ring显示文摘 | Friedrich MJ Gravius S Schmolders J | 2014 | Oper Orthop Traumatol2014，26，2： | 1 |
| 15 | The role of group I metabotropic glutamate receptors in schizophrenia 显示文摘 | Pietraszek M Nagel J Gravius A | 2007 | Amino Acids2007，32，2： | 1 |
| 16 | Lack of effect on bone healing of injectable BMP-2 augmented hyaluronic acid显示文摘 | Maus U Andereya S Gravius S | | 0，，12： | 1 |
| 17 | Uncemented femoral revision arthroplasty using a modular tapered,fluted titanium stem:5-to 16-year results of 163 cases显示文摘 | Wirtz DC Gravius S Ascherl R | 2014 | Acta Orthop2014，85，6： | 1 |
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