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| 1 | 基于纳米磁流体尸体CT血管造影的可行性探究显示文摘目的初步探索纳米磁流体(magnetic nanoparticle ferrofluid,MNPF)用于尸体计算机断层扫描血管造影(postmortem computed tomography angiography,PMCTA)的可行性。方法纳米粒子γ-Fe2O3(30nm)通过油酸(oleic acid,OA)进行表面修饰,修饰后物质移至液体石蜡油(paraffin oil,PO)中,使用高速搅拌器搅拌,制备成γ-Fe2O3含量为200g/L的MNPF。使用手动负压灌注法,将MNPF、PO和OA分别导入3只牛心脏的冠状动脉及左心室。将灌有不同液体的牛心移至CT机上扫描,观察冠脉或左心室显影情况。结果灌注MNPF的牛心,其冠脉呈现高信号,3D重建后可以较好地显示冠脉解剖形态。灌注PO和OA的牛心,冠脉呈现低信号,无法通过3D重建显示冠脉解剖形态。结论MNPF可以提高冠脉显影效果,对于PMCTA可能有一定的研究价值。 | 夏志远 Christine Bruguier Fabrice Dedoui Silke Grabherr Marc Augsburger 刘蓓蓓 | 2021 | 中国法医学杂志2021，36，3： | 7 |
| 2 | Modern post-mortem imaging:an update on recent developments显示文摘Modern post-mortem investigations use an increasing number of digital imaging methods,which can be collected under the term“post-mortem imaging”.Most methods of forensic imaging are from the radiology field and are therefore techniques that show the interior of the body with technologies such as X-ray or magnetic resonance imaging.To digitally image the surface of the body,other techniques are regularly applied,e.g.three-dimensional(3D)surface scanning(3DSS)or photogrammetry.Today’s most frequently used techniques include post-mortem computed tomography(PMCT),post-mortem magnetic resonance imaging(PMMR),post-mortem computed tomographic angiography(PMCTA)and 3DSS or photogrammetry.Each of these methods has specific advantages and limitations.Therefore,the indications for using each method are different.While PMCT gives a rapid overview of the interior of the body and depicts the skeletal system and radiopaque foreign bodies,PMMR allows investigation of soft tissues and parenchymal organs.PMCTA is the method of choice for viewing the vascular system and detecting sources of bleeding.However,none of those radiological methods allow a detailed digital view of the body’s surface,which makes 3DSS the best choice for such a purpose.If 3D surface scanners are not available,photogrammetry is an alternative.This review article gives an overview of different imaging techniques and explains their applications,advantages and limitations.We hope it will improve understanding of the methods. | Silke Grabherr Coraline Egger Raquel Vilarino Lorenzo Campana Melissa Jotterand Fabrice Dedouit | 2017 | Forensic Sciences Research2017，2，2： | 5 |
| 3 | 基于纳米磁流体尸体磁共振成像血管造影的可行性研究显示文摘目的初步探究纳米磁流体(magnetic nanoparticle ferrofluid,MNPF)在尸体磁共振成像血管造影(postmortem magnetic resonance angiography,PMMRA)的可行性。方法纳米粒子γ-Fe2O3(30nm)通过油酸(oleic acid,OA)表面修饰后,均匀分散在石蜡油(paraffin oil,PO)中,制备γ-Fe2O3浓度为0~1000μg/ml的MNPF。MNPF导入试管密封后固定在MR仪扫描床上,使用T1w-SE、T2w-SE和3DT2*w-GR扫描序列获取影像数据并分析影像学特点。将γ-Fe2O3浓度为0μg/ml、25μg/ml和1000μg/ml的MNPF灌注至牛离体心脏冠脉中,使用T1wSE、T2w-SE扫描序列获取影像数据并分析影像学特点。结果当γ-Fe2O3浓度在0~100μg/ml范围时,MNPF在T1wSE影像上呈现高信号,在T2w-SE影像上呈现低信号,在T2*w-SE影像上,MNPF随着γ-Fe2O3浓度的增加信号逐渐降低直至消失。当γ-Fe2O3浓度超过100μg/ml时,将可能导致磁敏感伪影的产生,而不适合造影剂的使用。结论一定浓度范围的γ-Fe2O3脂溶性MNPF,有可能成为PMMRA的T1阳性造影剂和信号可控T2*对比剂。 | 夏志远 Christine Bruguier Fabrice Dedouit Silke Grabherr Marc Augsburger 刘蓓蓓 | 2020 | 中国法医学杂志2020，35，6： | 4 |
| 4 | Oleic Acid (OA), A Potential Dual Contrast Agent for Postmortem MR Angiography (PMMRA): A Pilot Study显示文摘Summary:Choosing proper perfusates as contrast agents is an important aspect for postmortem magnetic resonance angiography(PMMRA).However,in this emerging field,the number of suitable kinds of liquid is still very limited.The objective of this research is to compare MR images of oleic acid(OA)with paraffin oil(PO)in vitro and in ex situ animal hearts,in order to evaluate the feasibility to use OA as a novel contrast agent for PMMRA.In vitro,OA,PO and water(control)were introduced into three tubes separately and T,weighted-spin echo(Tw SE)and T2w-SE images were acquired on a 1.5T MR scanner.In the second experiment,0A and PO were injected into left coronary artery(LCA)and left ventricle(LV)of ex situ bovine hearts and their Tw-SE,Tzw-SE,Tw-multipoint Dixon(Tjw-mDixon)and 3DT2w-mDixon images were acquired.The overall results indicate that OA may have a potential to be used as a dual(T and T2 based)contrast agent for PMMRA when proper sequence parameters are utilized.However,as the pilot study was based on limited number of animal hearts,more researches using OA in cadavers are needed to validate our findings. | Zhi-yuan XIA Christine BRUGUIER Fabrice DEDOUIT Silke GRABHERR Marc AUGSBURGER Bei-bei LIU | 2020 | Current Medical Science2020，40，4： | 3 |
| 5 | Postmortem imaging as a complementary tool for the investigation of cardiac death显示文摘In the past 2 decades,modern radiological methods,such as multiple detector computed tomography (MDCT),MDCT-angiography,and cardiac magnetic resonance imaging (MRI)were introduced into postmortem practice for investigation of sudden death (SD),including cases of sudden cardiac death (SCD).In forensic cases,the underlying cause of SD is most frequently cardiovascular with coronary atherosclerotic disease as the leading cause.There are many controversies about the role of postmortem imaging in establishing the cause of death and especially the value of minimally invasive autopsy techniques.This paper discusses the state of the art for postmortem radiological evaluation of the heart compared to classical postmortem examination,especially in cases of SCD.In SCD cases,postmortem CT is helpful to estimate the heart size and to visualize haemopericardium and calcified plaques and valves,as well as to identify and locate cardiovascular devices.Angiographic methods are useful to provide a detailed view of the coronary arteries and to analyse them,especially regarding the extent and location of stenosis and obstruction.In postsurgical cases,it allows verification and documentation of the patency of stents and bypass grafts before opening the body.Postmortem MRI is used to investigate soft tissues such as the myocardium,but images are susceptible to postmortem changes and further work is necessary to increase the understanding of these radiological aspects,especially of the ischemic myocardium.In postsurgery cases,the value of postmortem imaging of the heart is reportedly for the diagnostic and documentation purposes.The implementation of new imaging methods into routine postmortem practice is challenging,as it requires not only an investment in equipment but,more importantly,investment in the expertise of interpreting the images.Once those requirements are implemented,however,they bring great advantages in investigating cases of SCD,as they allow documentation of the body,orientation of sampling for further analyses and gathering of other information that cannot be obtained by conventional autopsy such as a complete visualization of the vascular system using postmortem angiography. | Katarzyna Michaud Pia Genet Sara Sabatasso Silke Grabherr | 2019 | Forensic Sciences Research2019，4，3： | 2 |
| 6 | CT-scan vs.3D surface scanning of a skull:first considerations regarding reproducibility issues显示文摘Three-dimensional surface scanning(3DSS)and multi-detector computed tomography(MDCT)are two techniques that are used in legal medicine for digitalizing objects,a body or body parts such as bones.While these techniques are more and more commonly employed,surprisingly little information is known about the quality rendering of digitalized three-dimensional(3D)models provided by each of them.This paper presents findings related to the measurement precision of 3D models obtained through observation of a study case,where a fractured skull reconstructed by an anthropologist was digitalized using both post-mortem imaging methods.Computed tomography(CT)scans were performed using an 8-row MDCT unit with two different slice thicknesses.The variability of 3D CT models superimposition allowed to assess the reproducibility and robustness of this digitalization technique.Furthermore,two 3D surface scans were done using a professional high resolution 3D digitizer.The comparison of 3D CT-scans with 3D surface scans by superimposition demonstrated several regions with significant differences in topology(average difference between+1.45 and-1.22 mm).When comparing the reproducibility between these two digitalizing techniques,it appeared that MDCT 3D models led in general to greater variability for measurement precision between scanned surfaces.Also,the reproducibility was better achieved with the 3D surface digitizer,showing 3D models with fewer and less pronounced differences(from+0.32 to-0.31 mm).These experiments suggest that MDCT provides less reproducible body models than 3D surface scanning.But further studies must be undertaken in order to corroborate this first impression,and possibly explain the reason for these findings. | Stella Fahrni Lorenzo Campana Alejandro Dominguez Tanya Uldin Fabrice Dedouit Olivier Deleemont Silke Grabherr | 2017 | Forensic Sciences Research2017，2，2： | 2 |
| 7 | Full - length transcriptome assembly from RNA - Seq data without a reference genome 显示文摘 | Grabherr M G Haas B J Yassour M | 2011 | Nat Biotechnol2011，29，7： | 1 |
| 8 | Two-step postmortem angiography with a modified heart-lung machine: preliminary results显示文摘 | Grabherr S Gygax E Sollberger B | 2008 | AJR Am J Roentgenol2008，190，2： | 1 |
| 9 | Multi-phase post-mortem CT angiography: development of a stan- dardized protocol显示文摘 | Grabherr S Doenz F Steger B et ol | 2011 | Int J Legal Med2011，125，6： | 1 |
| 10 | A regional impacl assess- ment of climate and land-use change on alpine vegetation 显示文摘 | Dirnbock T Dullinger S Grabherr G | 2003 | Journal of Biogeography2003，30，3： | 1 |
| 11 | Mental transformation abilities in patients with unilateral and bilateral vestibular loss显示文摘 | Grabherr L Cuffel C Guyot J P | | 0，，02： | 1 |
| 12 | Advances in post-mortem CT-angiography显示文摘 | Grabherr S Grimm J Dominguez A | 2014 | Br J Radiol2014，87，20： | 1 |
| 13 | Baculovirus surface display:construction and screening of a eukaryotic epitope library显示文摘 | Ernst W Grabherr R Wegner D | 1998 | Nucleic Acids Res1998，26，7： | 1 |
| 14 | Develop- ments in the use of baculoviruses for the surface display of complex eukaryotic proteins 显示文摘 | Grabherr R Ernst W Oker- Blom C | 2001 | Trends Bioteehnol2001，19，6： | 1 |
| 15 | Rational vector design for efficient non- viral gene delivery: challenges facing the use of plasmid DNA显示文摘 | Mairhofer J Grabherr R | 2008 | Mol Biotechnol2008，39，2： | 1 |
| 16 | Baculovirus display strategies:emerging tools for eukaryotic libraries and gene deliverys显示文摘 | Oker-Blom C Airenne KJ Grabherr R | 2003 | Brief Funct Genomic Proteomic2003，2，3： | 1 |
| 17 | Effects of microgravity on cognition : The case of mental imagery 显示文摘 | Grabherr L Mast F | 2010 | Journal of Vestibular Research2010，20，： | 1 |
| 18 | High-throughput sequencing of microdissected chromosomal regions 显示文摘 | Weise A Timmermann B Grabherr M | 2010 | Eur J Hum Genet2010，18，4： | 1 |
| 19 | Two-step postmortem angiography with a modified heart-lung machine: preliminary resuhs显示文摘 | Grabherr S Gygax E Sollberger B | 2008 | A JR2008，190，： | 1 |
| 20 | Postmortem angiography after vascular perfusion with diesel oil and a lipophilie contrast agent显示文摘 | Grabherr S Djonov V Friess A | 2006 | AIR2006，187，13： | 1 |
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