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| 1 | What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders?显示文摘The kallikrein-kinin system(KKS) is an intricate endogenous pathway involved in several physiological and pathological cascades in the brain. Due to the pathological effects of kinins in blood vessels and tissues, their formation and degradation are tightly controlled. Their components have been related to several central nervous system diseases such as stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy and others. Bradykinin and its receptors(B1R and B2R) may have a role in the pathophysiology of certain central nervous system diseases. It has been suggested that kinin B1R is up-regulated in pathological conditions and has a neurodegenerative pattern, while kinin B2R is constitutive and can act as a neuroprotective factor in many neurological conditions. The renin angiotensin system(RAS) is an important blood pressure regulator and controls both sodium and water intake. AngⅡ is a potent vasoconstrictor molecule and angiotensin converting enzyme is the major enzyme responsible for its release. AngⅡ acts mainly on the AT1 receptor, with involvement in several systemic and neurological disorders. Brain RAS has been associated with physiological pathways, but is also associated with brain disorders. This review describes topics relating to the involvement of both systems in several forms of brain dysfunction and indicates components of the KKS and RAS that have been used as targets in several pharmacological approaches. | Maria da Graa Naffah-Mazzacoratti Telma Luciana Furtado Gouveia Priscila Santos Rodrigues Simōes Sandra Regina Perosa | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | Design of an electric propulsion system for a quadrotor unmanned aerial vehicle显示文摘 | STEPANIAK M J van GRAAS F HAAG M U | 2009 | Journal of Aircraft2009，46，3： | 1 |
| 3 | Ranging airport pseudolite for local area augmentation 显示文摘 | Bartone C van Graas F | 2000 | IEEE Transactions on Aerospace and Electronic Systems2000，36，1： | 1 |
| 4 | Decomposition of Eucalyptus globulusleaves and three native leaf species (Alnus glutinosa, Castanea sati-va and Quercus faginea ) in a Portuguese low order stream 显示文摘 | CANHOTO C GRAA M S | 1996 | Hydrobiologia1996，333，2： | 1 |
| 5 | Natural killer T cells in adipose tissue prevent insulin re sistance显示文摘 | Schipper HS Rakhshandehroo M Van De Graa{ SF | 2012 | J Clin Invest2012，122，9： | 1 |
| 6 | Emer- ging pollutants in sewagesurface and drinking water in Galicia ( NW Spain) 显示文摘 | Rodil R Quintana J B Concha - Graa E | 2012 | Chemosphere2012，86，10： | 1 |
| 7 | Functional expression of the epithelial Ca(a+/ channels (TRPV5 and TRPV6)requires association of the S100A10-annexin 2 corn plex显示文摘 | van de Graa{ SF Hoenderop JG Gkika D | 2003 | Embo J2003，22，14： | 1 |
| 8 | GPS Interferometric Attitude and Heading Determination : Initial Flight Test Results 显示文摘 | Van Graas F Braasch M | 1991 | Journal of The Institute of Navigation1991，38，4： | 1 |
| 9 | Decoding navigation data messages from weak GPS signals显示文摘 | Soloviev A Graas F V Gunawardena S | 2009 | IEEE Transactions on Aerospace and Electronic Systems2009，45，2： | 1 |
| 10 | Application of light hydrocarbons (C 4 –C 13 ) to oil/source rock correlations:显示文摘 | W. Odden R.L. Patience G.W. Van Graas | 1998 | Organic Geochemistry1998，，12： | 1 |
| 11 | Risk Factors for 12- Month Comorbidity of Anxiety, Anxiety, and Substance Use Disorders: Findings From the Netherlands Mental Health Sur vey and Incidence Study显示文摘 | De Graa R Bijl RV Smit F | 2002 | Am J Psychiatry2002，159，： | 1 |
| 12 | A carrier phase batch processor for differential global positioning system: simulation and real data results 显示文摘 | Huang J Graas F | 2009 | Measurement Science and Technology2009，20，9： | 1 |
| 13 | Fast direct GPS P-Code acquisition显示文摘 | PANG Jing GRAAS Frank Van STAZYK Janusz | 2003 | GPS Solutions2003，7，3： | 1 |
| 14 | Precise velocity estimation using astand-alone GPS receiver显示文摘 | Van Graas F Soloviev A | 2004 | Navigation:Journal of the Instituteof Navigation2004，51，4： | 1 |
| 15 | The effects of phase fractionation on the composition of oils, condensates and gases 显示文摘 | Van Graas G W Gilje A E Isom T P | 2000 | Org Geochem2000，31，14： | 1 |
| 16 | Pollen and pistil in the progamic phase显示文摘 | GRAA B H J Derksen J W M MARIANI C | 2001 | Sex Plant Reprod2001，14，： | 1 |
| 17 | Transformation of the cultivated mushroom,Agaricus bisporus,to hygromycin B resistance显示文摘 | VAN DE RHEE M D GRAA P M A HURZING H J | 1996 | Molecular and General Genetics1996，250，： | 1 |
| 18 | Decoding Navigation Data Messages from Weak GPS Signals显示文摘 | SOLOVIEV A van GRAAS F GUNAWARDENA S | 2009 | IEEE Transactions on Aerospace and Electronic Systems2009，45，2： | 1 |
| 19 | Real time acquisition and tracking for GPS receiver显示文摘 | ALAQEELI A STARZYK J van GRAAS F | 2003 | IEEE Press2003，，： | 1 |
| 20 | The Influence of the Heat Treatment Temperature in the Magnetic Characteristics of a SiO2-LizO- Fe2 03 Glass Prepared by Sol-gel显示文摘 | Graa M P F Lopes J C Costa B F O | 2014 | Journal of Non-Crystalline Solids2014，391，： | 1 |
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