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| 1 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | A fast-settling CMOS op amp for SC circuits with 90-dB DC gain 显示文摘 | Klaas Bult Govert J G M | 1990 | IEEE Journal of Solid-state Circuits1990，25，6： | 1 |
| 3 | A fast-settling CMOS op amp for SC circuits with 90-dB DC gain显示文摘 | Bult K Govert J Geelen G M | 1990 | IEEE J Sol Sta Cir1990，25，6： | 1 |
| 4 | Evidence for the treat- ment of patients with pulmonary nodules:when is it lung cancer?: ACCP evidence -based clinical practice guidelines (2nd edition ) 显示文摘 | Wahidi M M Govert J A Goudar R K | 2007 | Chest2007，132，3： | 1 |
| 5 | Evidence for the treatment of patients with pulmonary nodules:when is it lung cancer?:ACCP evidence-based clinical practice guidelines(2nd edition)显示文摘 | Wahidi M M Govert J A Goudar R K | 2007 | Chest2007，132，3： | 1 |
| 6 | A fast settling CMOS op amp for SC circuits with 90 dB DC gain显示文摘 | BULT Klaas GOVERT J GEELEN G M | 1990 | IEEE JSSC1990，25，6： | 1 |
| 7 | An economic evaluation of prolonged mechanical ventilation 显示文摘 | Cox C E Carson S S Govert J A | 2012 | Crit Care Med2012，35，8： | 1 |
| 8 | Health-related quality of life and perceived quality of life in survivors of prolonged mechanical ventilation显示文摘 | Fischer KM Govert J Landucci DL | 2011 | Am J Respir Crit Care Med2011，183，： | 1 |
| 9 | Broncholith removal using cryotherapy during flexible bronchoscopy:a case report显示文摘 | Reddy A J Govert JA Sporn TA | 2007 | Chest2007，132，5： | 1 |
| 10 | A fast settling CMOS OpAmp for SC circuits with 90 dB DC gain显示文摘 | Govert K B Geelen J G M | 1990 | IEEE J Solid State Circuits1990，25，6： | 1 |
| 11 | A physical, yet simple, small-signal equivalent circuit for the hetero- junction bipolar transistor显示文摘 | Govert Y Tasker P J Bachem K H | 1997 | IEEE Trans Microw Theory Tech1997，45，1： | 1 |
| 12 | Preservation of microborings as fluid inclusions显示文摘 | Govert J A B Robert H G Stephen T H | 2004 | The Canadian Mineralogist2004，42，： | 1 |
| 13 | Health-related quality of life and perceived quality of life in survivors of prolonged mechanical ventilation显示文摘 | Fischer KM Govert J Landueci DL | 2011 | Am J Respir Crit Care Med2011，183，7： | 1 |
| 14 | A fast-settling CMOS op amp for SC circuit with 90-dB DC gain显示文摘 | Bult K Govert J G Geelen M | 1990 | IEEE J Sol Sta Circ1990，25，6： | 1 |
| 15 | A Quaternary climate record based on grain size analysis from the Luochuan loess section on the Central Loess Plateau, China 显示文摘 | Govert N Vandenberghe J Huissteden J | 2004 | Global and Planetary Change2004，41，： | 1 |
| 16 | Histologeal study of the thin replacement membrane of pertoratim 显示文摘 | GOVERTS PJ JACOB WA MARQUET J | 1998 | Acta Otolaryngal1998，105，： | 1 |
| 17 | A fast settling CMOS op amp for SC circuit with 90dB DC gain 显示文摘 | BULT K GOVERT J G GEELEN M | 1990 | IEEE J Sol Sta Circ1990，25，6： | 1 |
| 18 | Cost-effectiveness of collecting routine cytologic specimens during fiberoptic bronchoscopy for endoscopically visible lung tumor显示文摘 | Govert J A Kopita J M Matchar D | 1996 | Chest1996，109，2： | 1 |
| 19 | A Quaternary climate record based on grain size analysis from the Luochuan loess section on the Central Loess Plateau, China 显示文摘 | Govert N Vandenberghe J Huissteden J | 2004 | Global and Planetary Change2004，41，： | 1 |
| 20 | Prevalence and risk distribution of schistosomiasis among adults in Madagascar:a cross-sectional study显示文摘Background The goal to eliminate the parasitic disease of poverty schistosomiasis as a public health problem is aligned with the 2030 United Nations agenda for sustainable development goals,including universal health coverage(UHC).Current control strategies focus on school-aged children,systematically neglecting adults.We aimed at providing evidence for the need of shifting the paradigm of schistosomiasis control programs from targeted to generalized approaches as key element for both the elimination of schistosomiasis as a public health problem and the promotion of UHC.Methods In a cross-sectional study performed between March 2020 and January 2021 at three primary health care centers in Andina,Tsiroanomandidy and Ankazomborona in Madagascar,we determined prevalence and risk factors for schistosomiasis by a semi-quantitative PCR assay from specimens collected from 1482 adult participants.Univariable and multivariable logistic regression were performed to evaluate odd ratios.Results The highest prevalence of S.mansoni,S.haematobium and co-infection of both species was 59.5%,61.3%and 3.3%,in Andina and Ankazomborona respectively.Higher prevalence was observed among males(52.4%)and main contributors to the family income(68.1%).Not working as a farmer and higher age were found to be protective factors for infection.Conclusions Our findings provide evidence that adults are a high-risk group for schistosomiasis.Our data suggests that,for ensuring basic health as a human right,current public health strategies for schistosomiasis prevention and control need to be re-addressed towards more context specific,holistic and integrated approaches. | Sarah Katharina Gruninger Tahinamandranto Rasamoelina Rivo Andry Rakotoarivelo Anjarasoa Ravo Razafindrakoto Zaraniaina Tahiry Rasolojaona Rodson Morin Rakotozafy Patrick Richard Soloniaina Njary Rakotozandrindrainy Pia Rausche Cheick Oumar Doumbia Anna Jaeger Alexandre Zerbo Heidrun von Thien Philipp Klein Govert van Dam Egbert Tannich Norbert Georg Schwarz Eva Lorenz Jürgen May Raphael Rakotozandrindrainy Daniela Fusco | 2023 | Infectious Diseases of Poverty2023，12，2： | 0 |
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