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| 1 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | A demonstration project of Global Alliance against Chronic Respiratory Diseases:Prediction of interactions between air pollution and allergen exposure—the Mobile Airways Sentinel NetworK-Impact of air POLLution on Asthma and Rhinitis approach显示文摘This review analyzes the state and recent progress in the field of information support for pollen allergy sufferers.For decades,information available for the patients and allergologists consisted of pollen counts,which are vital but insufficient.New technology paves the way to substantial increase in amount and diversity of the data.This paper reviews old and newly suggested methods to predict pollen and air pollutant concentrations in the air and proposes an allergy risk concept,which combines the pollen and pollution information and transforms it into a qualitative risk index.This new index is available in an app(Mobile Airways Sentinel NetworK-air)that was developed in the frame of the European Union grant Impact of Air POLLution on sleep,Asthma and Rhinitis(a project of European Institute of Innovation and Technology-Health).On-going transformation of the pollen allergy information support is based on new technological solutions for pollen and air quality monitoring and predictions.The new information-technology and artificial-intelligence-based solutions help to convert this information into easy-to-use services for both medical practitioners and allergy sufferers. | Mikhail Sofiev Yuliia Palamarchuk Annabelle Bedard Xavier Basagana Josep M.Anto Rostislav Kouznetsov Rodrigo Delgado Urzua Karl Christian Bergmann Joao A.Fonseca Govert De Vries Michiel Van Erd Isabella Annesi-Maesano Daniel Laune Jean Louis Pepin Ingrid Jullian-Desayes Stephane Zeng Wienczyslawa Czarlewski Jean Bousquet | 2020 | Chinese Medical Journal2020，，13： | 3 |
| 3 | 欧洲法律下的提单管辖权条款显示文摘本文通过对荷兰法律及有关管辖权和民商事判决执行方面的两个主要公约 (EEX公约和 L ugano公约 )的介绍 ,结合大量的案例和欧共体法院对公约的解释 ,论述了欧洲法律下一个有效的标准格式中的管辖权条款所包含的条件及公约和各国国内法对当事人自由订立的标准格式中的管辖权条款的限制。 | Govert Smallegange 赵阳 裘剑锋 王庆 | 2000 | 中国海商法年刊2000，12，1： | 3 |
| 4 | Utilizing the ultrasensitive Schistosoma up-converting phosphor lateral flow circulating anodic antigen(UCP-LF CAA)assay for sample pooling-strategies显示文摘Background:Methodological applications of the high sensitivity genus-specific Schistosoma CAA strip test,allowing detection of single worm active infections(ultimate sensitivity),are discussed for efficient utilization in sample pooling strategies.Besides relevant cost reduction,pooling of samples rather than individual testing can provide valuable data for large scale mapping,surveillance,and monitoring.Method:The laboratory-based CAA strip test utilizes luminescent quantitative up-converting phosphor(UCP)reporter particles and a rapid user-friendly lateral flow(LF)assay format.The test includes a sample preparation step that permits virtually unlimited sample concentration with urine,reaching ultimate sensitivity(single worm detection)at 100%specificity.This facilitates testing large urine pools from many individuals with minimal loss of sensitivity and specificity.The test determines the average CAA level of the individuals in the pool thus indicating overall worm burden and prevalence.When requiring test results at the individual level,smaller pools need to be analysed with the pool-size based on expected prevalence or when unknown,on the average CAA level of a larger group;CAA negative pools do not require individual test results and thus reduce the number of tests.Results:Straightforward pooling strategies indicate that at sub-population level the CAA strip test is an efficient assay for general mapping,identification of hotspots,determination of stratified infection levels,and accurate monitoring of mass drug administrations(MDA).At the individual level,the number of tests can be reduced i.e.in low endemic settings as the pool size can be increased as opposed to prevalence decrease.Conclusions:At the sub-population level,average CAA concentrations determined in urine pools can be an appropriate measure indicating worm burden.Pooling strategies allowing this type of large scale testing are feasible with the various CAA strip test formats and do not affect sensitivity and specificity.It allows cost efficient stratified testing and monitoring of worm burden at the sub-population level,ideally for large-scale surveillance generating hard data for performance of MDA programs and strategic planning when moving towards transmission-stop and elimination. | Paul L.A.M.Corstjens Pytsje T.Hoekstra Claudia J.de Dood Govert J.van Dam | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 5 | A fast-settling CMOS op amp for SC circuits with 90-dB DC gain 显示文摘 | Klaas Bult Govert J G M | 1990 | IEEE Journal of Solid-state Circuits1990，25，6： | 1 |
| 6 | Evidence for the treatment of patients with pulmonary notlules : when is it lung cancer? ACCP evidence-based clinical practice guidelines (2nd edition) 显示文摘 | Wahidi MM Govert JA' Goudar RK | 2007 | Chest2007，132，3： | 1 |
| 7 | The responses of light interception, photosynthesis and fruit yield of cucumber to LED-lighting within the canopy显示文摘 | GOVERT TROUWBORST JOKE OOSTERKAMP SANDER W HOGEWONING | 2010 | Physiologia Plantarum2010，138，： | 1 |
| 8 | Methemoglobinemia after infusion of if- osfamide chemotherapy显示文摘 | Hadjiliadis D Govert JA | 2000 | Chest2000，118，： | 1 |
| 9 | Cost-effectiveness of collecting routine cytologic specimens during fiberoptic bronchoscopy for endoscopically visible lung tumor显示文摘 | Govert JA Kopita JM Matchar D | 1996 | Chest1996，109，： | 1 |
| 10 | A fast-settling CMOS op amp for SC circuits with 90-dB DC gain显示文摘 | Bult K Govert J Geelen G M | 1990 | IEEE J Sol Sta Cir1990，25，6： | 1 |
| 11 | Cost-effectiveness of collecting routine cytological specimens during fiberoptic bronchoscopy for endoscopically visible lung tumor显示文摘 | Kopita JM Matchar D | 1996 | Chest1996，109，2： | 1 |
| 12 | Evidence for the treat- ment of patients with pulmonary nodules : when is it lung cancer? : ACCP evidence-based chnical practice guidelines (2nd ed) 显示文摘 | Wahidi MM Govert JA Goudar RK | 2007 | Chest2007，132，3： | 1 |
| 13 | Evidence for the treat- ment of patients with pulmonary nodules : when is it lung cancer? ACCP evidence-based clinical practice guidelines (2nd edition) 显示文摘 | Wahidi MM Govert JA Goudar RK | 2007 | Chest2007，132，3： | 1 |
| 14 | Evidence for the treatment of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition) 显示文摘 | Wahidi MM Govert JA Goudar RK | 2007 | Chest2007，132，： | 1 |
| 15 | Evidence for the treat- ment of patients with pulmonary nodules:when is it lung cancer?: ACCP evidence -based clinical practice guidelines (2nd edition ) 显示文摘 | Wahidi M M Govert J A Goudar R K | 2007 | Chest2007，132，3： | 1 |
| 16 | Cost-effectiveness of col- lecting rutine cytologic specimens during fiberoptic bronchoscopy for endoscopically visible lung tumor显示文摘 | Govert JA Kopita JM Matchar D | 1996 | Chest1996，109，2： | 1 |
| 17 | Evidence for the treatment of patients with pulmonary nodules ; when is it lung cancer? ACCP evidence-based clinical practice guidelines(2nd edition) 显示文摘 | Wahidi MM Govert JA Gougar RK | 2007 | Chest2007，132，3： | 1 |
| 18 | Evidence for the treat-ment of patients with pulmonary nodules:when is it lung cancer:ACCP evi- dence-based clinical practice guidelines (2nd edition) 显示文摘 | Wahidi MM Govert JA Goudar RK | 2007 | Chest2007，132，3： | 1 |
| 19 | Evidence for the treatment of patients with pulmonary nodules:when is it lung cancer?:ACCP evidence-based clinical practice guidelines(2nd edition)显示文摘 | Wahidi M M Govert J A Goudar R K | 2007 | Chest2007，132，3： | 1 |
| 20 | A fast settling CMOS op amp for SC circuits with 90 dB DC gain显示文摘 | BULT Klaas GOVERT J GEELEN G M | 1990 | IEEE JSSC1990，25，6： | 1 |
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