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| 1 | Neuroendocrine carcinoma of the ampulla of Vater:a clinicopathologic evaluation显示文摘BACKGROUND:Only 105 cases of neuroendocrine tumor(NET)of the ampulla of Vater have been described, mostly as single case reports.The incidence of NET is rising.The changes in incidence may result from changes in detection.This study was to determine the relative incidence and clinicopathological characteristics of high- grade neuroendocrine carcinoma(small cell carcinoma and large cell carcinoma)of the ampulla of Vater at a single institution. METHODS:Sections from paraffin blocks of tumors of the ampulla of Vater taken from 45 patients who underwent Whipple's procedure and 6 patients who underwent palliative bypass between September 2003 and January 2007 were subjected to immunohistochemical analysis.The clinical and pathological data from 5 patients diagnosed with NET of the ampulla of Vater were analyzed. RESULTS:The patients were 3 men and 2 women,ranging in age from 39 to 47 years(mean 44 years).Operative procedures included Whipple's procedure in 4 patients and palliative bypass in 1 patient.Histopathological examination revealed large-cell neuroendocrine carcinoma in 2 patients,small cell carcinoma in 2,and carcinoid in 1.Three patients with high-grade neuroendocrine carcinoma who had undergone Whipple's procedure died at postoperatively 7,11,and 13 months.The patient who had undergone palliative triple bypass died 3 months after surgery.CONCLUSIONS:The relative incidence of high-grade neuroendocrine carcinomas of the ampulla of Vater is higher than that generally expected.The tumors behave aggressively and have a dismal prognosis despite aggressive treatment. | Eswaran Selvakumar Shanmugasundaram Rajendran Tirupporur Govindaswamy Balachandar Devy Gounder Kannan Satyanesan Jeswanth Palaniappan Ravichandran Rajagopal Surendran | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 7 |
| 2 | Long-term outcome of gastric access loop in hepaticojejunostomy显示文摘BACKGROUND:The incidence of hepaticojejunostomy stricture is 4%-10% in experienced centres. Many access loops have been designed and used to facilitate endoscopic intervention for this complication of hepaticojejunostomy. In this study, we investigated the effectiveness and safety of gastric access loop. METHODS:A retrospective analysis was conducted on 13 patients who had undergone hepaticojejunostomy with gastric access loop between June 1999 and September 2003. Eleven patients were followed up for a mean period of 51 months (range 20-81 months). Two patients were lost to follow up. RESULTS:On follow-up, 8 patients had patent jejuno- gastrostomy (end to side anastomosis between Roux loop of jejunum and stomach) and hepaticojejunostomy. Three patients developed stricture of jejunogastrostomy at 41 months, 63 months and 81 months of follow-up. Among these 3 patients, one also had hepaticojejunostomy stricture. In the patient with hepaticojejunostomy stricture, dilatation of jejunogastrostomy stricture was attempted but failed. None of the patients had any evidence of bile gastritis/cholangitis. There was no procedure related morbidity/mortality. CONCLUSIONS:Further studies involving large numbers of patients are required before wide application of gastric access loop in hepaticojejunostomy though it is a safer option than percutaneous transhepatic manipulations or revision surgery. | Eswaran Selvakumar Shanmugasundaram Rajendran Tirupporur G. Balachandar Devy Gounder Kannan Satyanesan Jeswanth Palaniappan Ravichandran Rajagopal Surendran | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，2： | 6 |
| 3 | Outcome of severe acute pancreatitis: Is there a role for conservative management of infected pancreatic necrosis?显示文摘BACKGROUND: Infected pancreatic necrosis is associated with high morbidity and mortality and is mandatory for surgical or radiological intervention. A selected group of patients with CT evidence of infected pancreatic necrosis and a comparatively lower APACHE score may be clinically stable throughout the course of their illness. METHODS: Case records of 52 patients with severe acute pancreatitis admitted from October 2000 to September 2005 were retrospectively analysed to assess the feasibility of conservative management of infected pancreatic necrosis. CT evidence of retroperitoneal air pockets, deteriorated clinical condition, sepsis and positive blood culture were used to diagnose infected pancreatic necrosis. RESULTS: In the 52 male patients reviewed, 24 patients had infected pancreatic necrosis. Eighteen patients who had progressively deteriorated clinical conditions required surgical intervention; five patients of whom (27.8%) died. Six patients with transient end organ dysfunction and stable clinical conditions were treated with prolonged administration of antibiotics and ICU support. All these patients recovered and discharged from the hospital, and no symptoms or readmission happened during follow-up of 6-44 months. CONCLUSIONS: Selected patients with infected pancreatic necrosis who are clinically stable with transient end organ dysfunction can be treated conservatively with a favourable outcome. Necrosectomy associated with high morbidityand mortality in these patients can be avoided. The need for intervention should be individualized and based on clinical conditions of the patients. | Amarapathy Sivasankar Devy Gounder Kannan Palaniappan Ravichandran Sathyanesan Jeswanth Tirupporur Govindasamy Balachandar Rajagopal Surendran | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 3 |
| 4 | Retention mucocele of distal viable remnant tip of appendix:An unusually rare late surgical complication following incomplete appendectomy显示文摘一个 67 年的老人与周期性的恰好更低的象限的 6 瞬间历史被介绍腹的疼痛。在体格检查上,一个含糊的团在恰好腰部的区域是摸得出的。他的平淡的实验室测试是正常的。Ultrasonography 与内部回响和液体部件在对正确的肾前面的恰好腰部的区域显示出低亚硫酸钠拟声损害。腹的提高对比的计算断层摄影术(CECT ) 显示出明确的低亚硫酸钠对上升冒号 / 盲肠侧面的稠密的膀胱的集体损害,不与冒号 / 盲肠的腔交流。在膀胱的集体损害的完全的开的切除以后,粗野病理学的检查表明阑尾的残余的浮肿的膀胱的膨胀充满了粘蛋白的材料。在组织病理学说的检查上,附录的粘蛋白的包囊腺瘤被证实。我们在远侧的可行阑尾的残余报导粘液囊肿形成的这稀罕不平常的迟了的复杂并发症,它是剩余物列在后面不完全后退阑尾切除术。这不平常的复杂并发症没在文学被描述,我们报导它以便加亮临床、放射学的怀疑的一个高索引为在已经经历了阑尾切除术周期性的腹的疼痛地介绍的一个病人从远侧的可行阑尾的残余产生的粘液囊肿的诊断是必要的事实。 | Maria Antony Johnson Damodaran Jyotibasu Palaniappan Ravichandran Satyanesan Jeswanth Devy Gounder Kannan RajagopalSurendran | 2006 | World Journal of Gastroenterology2006，12，3： | 2 |
| 5 | A validatedHPLC assay for the determination of /?-( -)-gossypol in humanplasma and its application in clinical pharmacokinetic studies显示文摘 | LIN Hongxia GOUNDER M K BERTINO J R | 2012 | JPharm Biomed Anal2012，66，： | 1 |
| 6 | Framework and extraframework tin sites in zeolite beta react glucose di? erently 显示文摘 | Bermejo- Deval R Gounder R Davis M E | 2012 | ACS Catal2012，2，： | 1 |
| 7 | Mitochondrial DNA sequence polymorphisms of five ethnic populations from northern China显示文摘 | Qing-Peng Kong Yong-Gang Yao Mu Liu Shu-Ping Shen Cai Chen Chun-Ling Zhu Malliya Gounder Palanichamy Ya-Ping Zhang | 2003 | Human Genetics2003，，5： | 1 |
| 8 | A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection显示文摘 | Hickey AJ Gounder L Moosa MY | 2015 | BMC Infect Dis2015，15，1： | 1 |
| 9 | Impairedtranscriptional activity of Nrf2 in age-related myocardialoxidative stress is reversible by moderate exercisetraining显示文摘 | Gounder SS Kannan S Devadoss D | 2012 | PLoS One2012，7，45： | 1 |
| 10 | Mitochondrial DNA sequence polymorphisms of five ethnic populations from northern China显示文摘 | Qing-Peng Kong Yong-Gang Yao Mu Liu Shu-Ping Shen Cai Chen Chun-Ling Zhu Malliya Gounder Palanichamy Ya-Ping Zhang | 2003 | Human Genetics2003，，5： | 1 |
| 11 | Diagnostic ac- curacy of a urine lipoarabinomannan enzyme-linked im- munosorbent assay for screening ambulatory HIV-infected persons for tuberculosis显示文摘 | Gounder C R Kufa T Wada N I | 2011 | J Acquir Immune Defic Syn- dr2011，58，2： | 1 |
| 12 | A phase I and pharmacologic study of the combination of marimastat and paclitaxel in patients with advanced malignancy显示文摘 | GOUNDER M MUCH J | 2003 | Med Sci Monit2003，9，8： | 1 |
| 13 | Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9- nitrocamptothecin显示文摘 | RAJENDRA R GOUNDER MK SALEEM A | 2003 | Cancer Res2003，63，12： | 1 |
| 14 | Factors that impact on the ability of biofumigants to suppress fungal pathogens and weeds of strawberry显示文摘 | Mattner S W Porter I J Gounder R K | 2007 | Crop Protection2007，27，8： | 1 |
| 15 | Routing in LEO - based Satellite Networks显示文摘 | Vidyashankar V Gounder Ravi Prakash Hosame Abu Ama ra | 1999 | Proceed ings of IEEE Emerging Technologies Syrup: Wireless Corn munications and Systems1999，，： | 1 |
| 16 | Routing in LEO-based satellite networks显示文摘 | Gounder V V Prakash R | 1999 | Wireless Communications and Systems1999，22，： | 1 |
| 17 | Impaired transcriptional activity of Nrf2 in agerelated myocardial oxidative stress is reversible by moderate exercise training显示文摘 | Gounder SS Kannan S Devadoss D | 2012 | PLoS One2012，7，45： | 1 |
| 18 | Molecular basis for primary and secondary tyrosine kinase inhibitor resistance in gastrointestinal stromal tumor 显示文摘 | Gounder MM Maki RG | 2011 | Cancer Chemother Pharmaco12011，67，7： | 1 |
| 19 | Half of threshold algo- rithm: An enhanced linear adaptive skipping training algo- rithm or muhilayer feedforward neural networks 显示文摘 | Ramasamy M D Gounder K S | 2014 | Amer- ican Journal of Applied Sciences2014，11，1： | 1 |
| 20 | Multidisciplinary management of recurrent chordomas显示文摘 | Yamada Y Gounder M Laufer I | 2013 | Curt Treat Options Oncol2013，14，3： | 1 |
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