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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Novel approach to nonlinear non-Gaussian Bayesian state estimation显示文摘 | Gordon N J Salmond D J Smith A F M | 1993 | IEE Proceedings-F1993，140，2： | 2 |
| 3 | Macrodiversity power control in hierarchical CDMA cellular systems显示文摘 | KIM J Y GORDON L S IAN F A | 2001 | IEEE Journal on Selected Areas in Commun2001，19，2： | 2 |
| 4 | 2004英国高血压学会高血压治疗指南(BHS-IV):概要显示文摘在高血压领域,不断出现的新证据已日益受到关注。例如:血压可作为心血管疾病的一个危险因素;改进生活方式对于预防和治疗高血压的重要意义;不同类型药物的有效性和安全性;高危高血压患者包括糖尿病患者的治疗;心血管疾病总体危险性评估的重要性以及使用他汀类药物所获得的额外益处。 | Bryan Williams Neil R Poulter Peter S Sever Morris J Brown Mark Davis Gordon T McInnes John F Potter 邱洪 | 2004 | 英国医学杂志中文版2004，7，5： | 2 |
| 5 | Novel approach to non-finear/non-Gnussian Bayesian state estimation显示文摘 | N J Gordon D J Salmond A F M Smith | 1993 | IEE Proceedings-F1993，140，2： | 1 |
| 6 | Differential gene expression in endometrium,endometrial lymphocytes,and trophoblasts during successful and abortive embryo implantation显示文摘 | CHANDRAKANT T GORDON P B YUAN F | 2006 | J Immunol2006，176，： | 1 |
| 7 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 8 | Using genetic algorithms for concept learning显示文摘 | DE JONG K A SPEARS W M GORDON F D | 1993 | Machine Learning1993，13，： | 1 |
| 9 | Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading 显示文摘 | CARLSON C J BOOTH F W GORDON S E | 1999 | Am J Physiol1999，277，： | 1 |
| 10 | Nonalcoholic steatohepatitis:a pilot study 显示文摘 | Sheth S G Gordon F D Chopra S | 1997 | Ann Intern Med1997，126，2： | 1 |
| 11 | Novel Ap- proach to Nonlinear/non-Gaussian Bayesian State Estimation显示文摘 | Gordon N J Salmond D J Smith A F M | 1993 | lEE Proceedings-F1993，140，2： | 1 |
| 12 | Sucrose synthase in legume modules is essential for nitrogen fixation显示文摘 | GORDON A J MINCHIN F R JAMES C L | 1999 | Plant Physiol1999，120，3： | 1 |
| 13 | Novel approach to nonlinear/non-Gaussian Bayesian state estimation显示文摘 | GORDON N J SALMOND D J SMITH A F M | 1993 | IEE Proceedings on Radar and Signal Processing1993，140，2： | 1 |
| 14 | HPLC Determination of Catechins in Tea Leaves and Tea Extracts Using Relative Response Factors显示文摘 | Wang H F Gordon J P Helliwell K | 2003 | Food Chemistry2003，81，2： | 1 |
| 15 | Novel ap-proach to nonlinear/non-gaussian bayesian state esti-mation显示文摘 | Gordon N J Salmond D J Smith A F M | 1993 | IEE Proceedings on Radar and SignalProcessing1993，140，2： | 1 |
| 16 | A novel approach to nonlinear1 non-gaussian bayesian state estimatior显示文摘 | Gordon N J Salmond D J Smith A F M | | 0，，： | 1 |
| 17 | Integrated con- trol methodologies for road vehicles 显示文摘 | Gordon T Howell M Brandao F | 2003 | Vehicle System Dynamics2003，40，1： | 1 |
| 18 | Novel Approach to Nonlinear/Non-Gaussian Bayesian State Est-Imation显示文摘 | Gordon N J Salmond D J Smith A F M | 1993 | IEEE Proceedings-F1993，140，2： | 1 |
| 19 | Novel approach to nonlinear/non-Gaussian Bayesian state estimation显示文摘 | Salmond D J Smith A F M | | IEE Procedings F0，1993，： | 1 |
| 20 | An ex vivo investigation into the effects orthodontic brackets显示文摘 | Bradburn G Mclube J F Gordon P H | 1998 | Br J Orthod1998，25，： | 1 |
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