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| 1 | Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells显示文摘Objective:To examine the role of carvacrol in modulating PI3 K/AKT signaling involved in human breast cancer pathogenesis using in vitro experimental model MCF-7 cells.Methods:MTT and lactate dehydrogenase assays were performed with cells treated with different doses of carvacrol(0–250μmol/L)at different time points(24 and 48 h).The nuclear morphology was assessed in MCF-7 cells with propidium iodide(PI)and acridine orange/ethidium bromide(AO/EB)staining and analyzed by fluorescence microscopy.Events like cell cycle arrest and apoptosis were observed by flow cytometric analysis and expressions of p-Rb,cyclin D1,cyclin-dependent kinase 4(CDK4),CDK6,Bax,Bcl-2,PI3 K/p-AKT were analyzed by immunoblot.Results:Carvacrol significantly reduced cell viability with the half maximal inhibitory concentration value of 200μmol/L at 24 and 48 h(P<0.05).importantly,there was a significant increase in the accumulation of the G0/G1 phase upon treatment with carvacrol in MCF-7 cells(P<0.05 or P<0.01).A remarkable decrease in protein expressions of p-Rb,cyclin D1,CDK4 and CDK6 denoted cell cycle arrest(P<0.05 or P<0.01).In addition,carvacrol treatment significantly inhibited PI3 K/p-AKT protein expressions leading to induction of apoptosis mediated by decreased Bcl2 and increased Bax protein expressions.Further,Annexin V/PI staining by FACS analysis,dual staining by AO/EB and PI staining studies suggested induction of apoptosis by carvacrol through PI3 K/Akt signaling pathway in MCF-7 cells.Conclusion:Carvacrol significantly inhibited the breast cancer MCF-7 cell proliferation and induced apoptosis via suppressing PI3/AKT signaling pathway. | Ashok Mari Gopikrishnan Mani Sirpu Natesh Nagabhishek Gopaiakrishnan Balaraman Nirmala Subramanian Fathima Bushra Mirza Jagan Sundaram Devaki Thiruvengadam | 2021 | Chinese Journal of Integrative Medicine2021，27，9： | 3 |
| 2 | A theory of power-law distributions in financial market fluctuations显示文摘 | Gabaix X Gopikrishnan P Plerou V | | 0，，423： | 1 |
| 3 | A model for the growth dynamics of economic organizations显示文摘 | Amaral L A N Gopikrishnan P Plerou V Stanley H E | 2001 | Physica A2001，299，： | 1 |
| 4 | Statistical Properties of the Volatility of Price Fluctuations显示文摘 | LIU Y H GOPIKRISHNAN P CIZEAU P | 1999 | Physical Review E1999，60，2： | 1 |
| 5 | Inverse cubic law for the distribution of stock price variations显示文摘 | P. Gopikrishnan M. Meyer L.A.N. Amaral H.E. Stanley | 1998 | The European Physical Journal B1998，，2： | 1 |
| 6 | A theory of power law distributions in financial market fluctuations显示文摘 | Gabaix X Gopikrishnan P Plerou B | 2003 | Nature2003，423，6937： | 1 |
| 7 | Institutional investors and stock market volatility显示文摘 | Gabaix X Gopikrishnan P Plerou B | 2006 | Quarterly Journal of Economics2006，121，2： | 1 |
| 8 | Pulmonary biocompatibility assessment of inhaled single-wall and multiwall carbon nanotubes in BALB/c mice显示文摘 | Ravichandran P Baluchamy S Gopikrishnan R | 2011 | J Biol Chem2011，286，29： | 1 |
| 9 | Scaling and correlation in financial data显示文摘 | Gopikrishnan P Plerou V Liu Y | 2000 | Physica A2000，287，： | 1 |
| 10 | A theory of power-law distributions in financial market fluctuations 显示文摘 | Gabaix X Gopikrishnan P Plerou V | 2003 | Nature2003，423，： | 1 |
| 11 | A model for the growth dynamics of economic organizations 显示文摘 | Amaral L A N Gopikrishnan P Plerou V | 2001 | Physica A2001，299，： | 1 |
| 12 | Scaling of the distribution of fluctuations of financial market indices显示文摘 | Gopikrishnan P Plerou V Amaral L A N | 1999 | Physical Review E1999，60，5： | 1 |
| 13 | Econophysics finacial Time Series from a Statistical Physics Point of View显示文摘 | Gopikrishnan P Rosenow Bemd | 1999 | Physics A1999，60，6： | 1 |
| 14 | Statistical Properties of Share Volume Trade in Financial Markets显示文摘 | Plerou V Gabaix X | 2000 | Physical Review E2000，62，4： | 1 |
| 15 | Random Matrix Approach to Cross Correlations in Financial Data显示文摘 | Vasiliki Plerou Parameswaran Gopikrishnan | | Physical Review E0，，65： | 1 |
| 16 | Scaling and correlation in financial time series显示文摘 | V Plerou | 2000 | Physica A2000，287，2000： | 1 |
| 17 | Economic index 显示文摘 | Vasiliki Plerou Parameswaran Gopikrishnan Bernd Rosenow | 1995 | Nature 376(1995)1995，4649，： | 1 |
| 18 | Scaling of the distribution of price fluctuations of individual companies显示文摘 | PLEROU V GOPIKRISHNAN P AMARAL L A N | | 0，，60： | 1 |
| 19 | Statistical properties of the volatility of price fluctuations显示文摘 | Liu Y Gopikrishnan P Stanley H E | 1999 | Physical Review E1999，60，2： | 1 |
| 20 | A study of the bactericidal, anti-biofouling, cytotoxic and antioxidant properties of actinobacterially synthesised silver nanoparticles显示文摘 | Shanmugasundaram T Radhakrishnan M Gopikrishnan V | 2013 | Colloids Surf B Biointerfaces2013，23，3： | 1 |
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