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| 1 | Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney显示文摘Despite the introduction of potent immunosuppressive medications within recent decades, acute rejection still accounts for up to 12% of all graft losses, and is generally associated with an increased risk of late graft failure. Current detection of acute rejection relies on frequent monitoring of the serum creatinine followed by a diagnostic renal biopsy. This strategy is flawed since an alteration in the serum creatinine is a late clinical event and significant irreversible histologic damage has often already occurred. Furthermore, biopsies are invasive procedures that carry their own inherent risk. The discovery of non-invasive urinary biomarkers to help diagnose acute rejection has been the subject of a significant amount of investigation. We review the literature on urinary biomarkers here, focusing on specific markers perforin and granzyme B m RNAs, FOXP3 m RNA, CXCL9/CXCL10 and mi RNAs. These and other biomarkers are not yet widely used in clinical settings, but our review of the literature suggests that biomarkers may correlate with biopsy findings and provide an important early indicator of rejection, allowing more rapid treatment and better graft survival. | Basma Merhi George Bayliss Reginald Y Gohh | 2015 | World Journal of Transplantation2015，5，4： | 4 |
| 2 | Overexpressionofthec-mycprotooncogeneincoloretalcarcinomaisassociatedwithareducedmortalitythatisabrogatedbypointmutationofthep53tumorsuppressorgene显示文摘 | SMITHDR GOHHS | 1996 | ClinCancerRes1996，2，： | 1 |
| 3 | Management of thrombo- philia in renal transplant patients 显示文摘 | Morrissey PE Ramirez PJ Gohh RY | 2002 | Am J Transplant2002，2，9： | 1 |
| 4 | Tacrolimus in diabetic kid- ney transplant reicpiets: pharmacokinetics and application of a lim- ites sampling strategy显示文摘 | Mendonza AE Zahir H Gohh RY | 2007 | Ther Drug Monit2007，29，： | 1 |
| 5 | The current conveyor:history,progress and new results显示文摘 | SEDRA A S ROBERTS G W GOHH F | 1990 | In Proc of IEE Pt G1990，137，2： | 1 |
| 6 | Multidrug resistance-associated protein 2(MRP2/ABCC2)haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients显示文摘 | Ogasawara K Chitnis SD Gohh RY | 2013 | Clin Pharmacokinet2013，52，9： | 1 |
| 7 | The current conveyors: history, progress and new result显示文摘 | ROBERTS G W GOHH F | 1990 | IEE Proc G1990，137，2： | 1 |
| 8 | lmmunosuppression after renal allograft failure: a survey of US practices 显示文摘 | Bayliss GP Gohh RY Morrissey PE | 2013 | Clin Transplant2013，27，6： | 1 |
| 9 | Determination of cyclosporine in saliva using liquid chromatography-tandem mass spectrometry显示文摘 | MENDONZA A GOHH R AKHLAGHI F | 2004 | Ther Drug Monit2004，26，5： | 1 |
| 10 | Multidrug resistance- associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of taerolimus in kidney transplant recipients显示文摘 | Ogasawara K Chitnis S D Gohh R Y | 2013 | Clin Pharmacokinet2013，52，9： | 1 |
| 11 | The current conveyor:history,progress and new results 显示文摘 | Sedra A S Roberts G W Gohh F | 1990 | IEE Proceedings1990，137，2： | 1 |
| 12 | Rapamycin Treatment of Healthy Pigs Subjected to Acute Myocardial Ischemia-Reperfusion Injury Attenuates Cardiac Functions and Increases Myocardial Necrosis显示文摘 | Antonio D. Lassaletta Nassrene Y. Elmadhun Arthus V.D. Zanetti Jun Feng Javier Anduaga Reginald Y. Gohh Frank W. Sellke Cesario Bianchi | 2013 | The Annals of Thoracic Surgery2013，，： | 1 |
| 13 | Determination of cyclosporine in saliva using liquid chromatography - tandem mass spectrometry 显示文摘 | Mendonza A Gohh R Akhlaghi F | 2004 | Ther Drug Monit2004，26，： | 1 |
| 14 | Management of thrombophilia in renal transplant patients显示文摘 | Ramirez PJ Gohh RY | 2002 | Am J Transplant2002，2，9： | 1 |
| 15 | Multidrug resist-ance-associated protein 2 (MRP2/ABCC2) haplotypes signifi-cantly affect the pharmacokinetics of tacrolimus in kidneytransplant recipients 显示文摘 | Ogasawara K Chitnis SD Gohh RY | 2013 | Clin Pharmacokinet2013，52，9： | 1 |
| 16 | Management of thrombophilia in renal transplant patients显示文摘 | Ramirez P J Gohh R Y | 2002 | Am J Transplant2002，2，9： | 1 |
| 17 | Enhanced reduction of fasting total homocysteine levels with supraphysiological versus standard multivitamin dose folic acid supplementation in renal transplant recipients 显示文摘 | Beaulieu AJ Gohh RY Han H | 1999 | Arteriosclerosis Thrombosis and Vascular Biology1999，19，12： | 1 |
| 18 | Correlation of clinical outcomes after taerolimus conversion for resistant kidney rejection or eyclosporine toxicity with pathologic staging by the Banff criteria 显示文摘 | Morrissey PE Gohh R Shaffer D | 1997 | Transplantation1997，63，6： | 1 |
| 19 | Determination of cyclosporine in saliva using liquid chromatography-tandem mass spectrometry 显示文摘 | Mendonza A Gohh R Akhlaghi F | 2004 | Ther Drug Monit2004，26，5： | 1 |
| 20 | Chronic renal transplantation:a model for the hyperhomoeysteinemia of renal insufficiency显示文摘 | Bostom AG Kronenberg F Gohh RY | 2001 | Atherosclerosis2001，156，1： | 1 |
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