|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 选择性环氧化酶2抑制剂和传统非甾体抗炎药增加粥样血栓形成的风险吗?随机试验的荟萃分析显示文摘目的:评价选择性环氧化酶2(COX-2)抑制剂和传统的非甾体类抗炎药(NSMDs)在发生血管事件上的风险性。设计:对已发表和未发表随机试验的表格式资料进行荟萃分析,对传统 NSAIDs 的作用进行间接评估。资料来源:资料分别来源于 Medline 和 Embase(1966年1月至2005年4月);食品与药品管理局记录;以及诺华、辉瑞、默克公司的资料。回顾方法:符合以下条件的随机试验入组本研究:一种选择性 COX-2抑制剂与安慰剂比较或一种选择性 COX-2抑制剂与一种传统的 NSAID之间对比;用药持续时间至少4周;包含严重血管事件方面的信息,如心肌梗死、卒中或由于血管事件死亡。各个独立研究者和药厂为本研究提供了有关随机化的病人数目、血管事件的数目以及每个随机化小组中随访的人时(Person time)等信息。结果:在与安慰剂对比的试验中,选择性COX-2抑制剂使严重血管事件发生率增加42%(1.2%/年比0.9%/年;率比1.42,95%可信区间1.13~1.78;P=0.005);不同的选择性 COX-2抑制剂之间没有显著性差异。这主要归因于心肌梗死的风险增加(0.6%/年比0.3%/年;1.86,1.33~2.59;P=0.0003),在其他血管性事件上没有明显的区别。在为时至少1年的试验中(平均2.7年),血管事件的率比是1.45(1.12~1.89;P=0.005)。总的来说,严重血管事件的发生率在选择性 COX-2抑制剂和任何传统 NSAID 之间没有差异(1.0%/年比0.9%/年;1.16,0.97~1.38;P=0.1)。然而,在选择性 COX-2抑制剂与萘普生对比的试验(1.57,1.21~2.03)和选择性COX-2抑制剂与非萘普生类 NSAIDs 相比较的试验之间(0.88,O.69~1.12),我们发现了统计学差异。与安慰剂比较血管事件的总体比率如下:萘普生0.92(0.67~1.26),布洛芬1.51(0.96~2.37),双氯芬酸1.63(1.12~2.37)。结论:选择性 COX-2抑制剂可以中等度增加血管事件的风险性,大剂量布洛芬和双氯芬酸同样具有此作用,但大剂量萘普生不明显增加血管事件的风险性。 | Patricia M Kearney Colin Baigent Jon Godwin Heather Halls Jonathan R Emberson Carlo Patrono 徐东(译) 张卓莉(校) | 2006 | 英国医学杂志中文版2006，9，5： | 4 |
| 2 | Human intestinal parasitism,potable water availability and methods of sewage disposal among nomadic Fulanis in Kuraje rural settlement of Zamfara state显示文摘Objective:To ascertain the level of intestinal parasites vis-a-vis the quality of housing and water supply,and sanitary conditions among the people of Kuraje village in Zamfara state. Methods:The study was cross sectional in nature.Individual households were selected using systematic random sampling methods and pre-tested questionnaires were administered to all the members of each household.Stool samples were collected and processed using standard laboratory procedures.Housing conditions,sources of water and sanitary conditions of the households were also inspected.Results were analysed using Epi Info 2006 model.Results: The prevalence of intestinal parasites was 67.0%(347/519).72.3%(251/347),17.0%(59/347),and 10.7%(37/347) had one,two and three or more parasites,respectively.The associated factors with intestinal parasites were poor housing and sanitary conditions,lack of potable water and illiteracy.The commonest parasites encountered were hookworm(22.0%),Ascaris lumbricoides (18.5%),and Strongyloides stercoralis(15.6%) while the least common was Enterobius vermicularis (1.6%).Others were Giardia lamblia(5.7%),Hymenolepsis nana(5.0%),Trichuris trichiura(8.8%), Entamoeba histolytica(14.4%) and Schistosoma mansoni(8.4%).Conclusions:The infection rate of intestinal parasites in Kuraje village is high.More efforts should be intensified towards improvement in sanitary and housing standards,supply of potable water and institution of a more comprehensive literacy programme for the people of the community. | Godwin T Jombo James G Damen Hauwa Safiyanu Friday Odey Emmanuel M Mbaawuaga | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，6： | 2 |
| 3 | The Strobilurin Fungicides 显示文摘 | BARTLETT D W CLOUGH J M GODWIN J R | 2002 | Pest Manag Sci2002，58，： | 1 |
| 4 | Potassium management for brown midrib sorghum x Sudan grass as replacement for corn silage in the northeastern USA显示文摘 | Ketterings Q M Godwin G Cherney J | 2005 | Agronomy&Grop Science2005，191，： | 1 |
| 5 | MHC class Ⅱ A genes in the channel catfish (Ictalurus punctatus) 显示文摘 | Godwin U B Flores M Quiniou S | 2000 | Developmental and Comparative Immunology2000，24，67： | 1 |
| 6 | Review the strobilurin fungicides 显示文摘 | Bartlett D W Clough J M Godwin J R | 2002 | Pest Manag Sci2002，58，7： | 1 |
| 7 | Hoxc13 mutant mice lack external hair显示文摘 | Godwin A R Capecchi M R | 1998 | Genes Dev1998，12，： | 1 |
| 8 | Potassium management for brown midrib sorghum sudangrass as replacement for corn silage in the north-castern USA显示文摘 | Ketterings Q M Godwin G Chemey J H | 2005 | Journal of Agronomy and Crop Science2005，191，： | 1 |
| 9 | Frequent expression of a mutant epidermal growth factor receptor in mutiple human tumors 显示文摘 | Moscatello DK Holgado-Madruga M Godwin A | 1995 | Cancer Res1995，55，： | 1 |
| 10 | Long-term trends in sodium and chloride in the Mohawk River, New York: The effect of fifty years of road salt application 显示文摘 | Godwin K S Hafner S D Buff M F | 2003 | Environmental Pollution2003，，124： | 1 |
| 11 | Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors显示文摘 | Moscatello DK Holgado-Madruga M Godwin AK | 1995 | Cancer Res1995，55，23： | 1 |
| 12 | Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer:Evidence supporting a mesothelial-toepithelial transition显示文摘 | Bendoraite A Knouf E C Garg K S Parkin R K Kroh E M O'Briant K C Ventura A P Godwin A K Karlan B Y Drescher C W and others | | 0，，01： | 1 |
| 13 | Models for integrating rehabili- tation and primary care:a scoping study显示文摘 | McColl M A Shortt S Godwin M | 2009 | Archives of physical medi- cine and rehabilitation2009，90，9： | 1 |
| 14 | Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors显示文摘 | Moscatello DK Holgado-Madruga M Godwin AK | 1995 | Cancer Res1995，55，23： | 1 |
| 15 | The Strobilurin Fungicides显示文摘 | BARTLETT D W CLOUGH J M GODWIN J R | 2002 | Pest Manag Sci2002，58，： | 1 |
| 16 | Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection显示文摘 | Jenkins C Garcia W Godwin M J | 2008 | Journal of Virology2008，82，7： | 1 |
| 17 | Long- Term Health--Related Quality of Life of Stroke Survivors and Their Spousal Caregivers显示文摘 | godwin K M Ostwald S Cron S G | 2013 | NeuroseiNurs2013，45，2： | 1 |
| 18 | The Strobilurin Fungicides显示文摘 | BARTLETT D W CLOUGH J M GODWIN J R | 2002 | Pest Management Science2002，58，： | 1 |
| 19 | The Strobilurin Fungicides 显示文摘 | BARTLETT D W CLOUGH J M GODWIN J R | 2002 | Pest Manag Sci2002，58，： | 1 |
| 20 | MHC class II A genes in the channel catfish (Ictalurus punctatus) 显示文摘 | Godwin U B Flores M Quiniou S | 2000 | Dev Comp Immunol2000，24，67： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员