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| 1 | The phosphorus cycle in coastal marine sediments 显示文摘 | Sundby B Gobeil C Silberberg N | 1992 | Limnology and Oceanography1992，37，6： | 2 |
| 2 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 3 | The phosphorus cycle in coastal marine sediments显示文摘 | SUNDBY B GOBEIL C SILBERBERG N | 1992 | Limnol Oceanogr1992，37，： | 1 |
| 4 | Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1显示文摘 | Gobeil FJ Zhu T Brault S | 2006 | J Biol Chem2006，281，16： | 1 |
| 5 | The phosphorus cycle in coastal marine sediments 显示文摘 | SUNDBY B GOBEIL C SILVERBERG N | 1992 | Limnol Oceanogr1992，37，： | 1 |
| 6 | Augmented vasoconstriction and thromboxane formation by 15-F (2t)-isoprostane (8-iso-prostaglandin F (2alpha)) in immature pig periventricular brain microvessels显示文摘 | Hou X Gobeil F Jr Peri K | 2000 | Stroke2000，31，2： | 1 |
| 7 | Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma - causing myocilin mutants 显示文摘 | Gobeil S Rodrigue MA Moisan S | 2004 | Invest Ophthalmol Vis Sci2004，45，10： | 1 |
| 8 | Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation 显示文摘 | Anderson K J Teuber S S Gobeille A | 2001 | Nutr2001，131，11： | 1 |
| 9 | Mercury profiles in sediments of the Arctic Ocean basins显示文摘 | Gobeil C Macdonald R W Smith J N | 1999 | Environmental Science & Technology1999，33，： | 1 |
| 10 | Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1显示文摘 | Gobeil F Jr Bernier SG Vazquez-Tello A | 2003 | J Biol Chem2003，278，38： | 1 |
| 11 | RNA interference in mammals:behind the screen显示文摘 | Campeau E Gobeil S | | 0，，04： | 1 |
| 12 | MicroRNAs in Gene Regulation:When the Smallest Governs It All显示文摘 | Ouellet DL Perron MP Gobeil LA | 2006 | Journal of Biomedicine and Biotechnology2006，，69： | 1 |
| 13 | The phosphorus cycle in coastal marine sediments 显示文摘 | Sundby B Gobeil C Silverberg N | 1992 | Limnology and Oceanography1992，37，6： | 1 |
| 14 | The phosphorus cycle in coastal marine sediments显示文摘 | SUNDBY B GOBEIL C SILBERBERG N | 1992 | Limnology and Ocea- nography1992，37，6： | 1 |
| 15 | Industrial relations performance, economic performance, and QWL programs: An inter - plant analysis 显示文摘 | Katz H C Kochan T A Gobeille K | 1987 | Industrial and Labor Rela- tions Review1987，37，1： | 1 |
| 16 | Walnut polyphenolics inhibit in vitro human plasma and LDL oxi- dation显示文摘 | Anderson K J Teuber S S Gobeille A | 2001 | Nutr2001，131，： | 1 |
| 17 | Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation显示文摘 | ANDERSON K J TEUBER S S GOBEILLE A | 2001 | J Nutr2001，131，11： | 1 |
| 18 | Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1 显示文摘 | Gobeil FJr Zhu T Brault S | 2006 | J Biol Chem2006，281，16： | 1 |
| 19 | The phosphorus cycle in coastal marine sediments 显示文摘 | Sundby B Gobeil C Silverberg N | 1992 | Limnol Oceanogr1992，37，6： | 1 |
| 20 | Atlantic water flow pathways revealed by lead contamination in Arctic basin sediments显示文摘 | Charle Gobeil Robie W Macdonald John N Smith | 2001 | Sci2001，293，17： | 1 |
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