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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | MRI Before Reexcision Surgery in Patients with Breast Cancer显示文摘 | Janie ML Susan GO Brian JC | 2004 | AJR2004，182，2： | 1 |
| 3 | Increased prevalence of subclini- cal and clinical hypothyroidism in persons with chronic kidney dis- ease 显示文摘 | Lo JC Chertow GM Go AS | 2005 | Kidney Int2005，67，3： | 1 |
| 4 | The efieaey of epidural anesthesia for endoscopic preperitonealhemiontaaphy: a prospective study显示文摘 | Azurin DJ Go IS Cwik JC | 1996 | J Laparoendose Surg1996，6，6： | 1 |
| 5 | Detection of groin hernia with physical examination,ultrasound,and MRI compared with laparoscopic findings显示文摘 | Berg JC Valois JC Go PM | 1999 | Invest Radiol1999，34，12： | 1 |
| 6 | Radiological anato- my of the groin region显示文摘 | van den Berg JC de Valois JC Go PM | 2000 | Eur Radiol2000，10，4： | 1 |
| 7 | Mineral bone disorder in chronic kidney disease:head-to-head comparison of the 5/6nephrectomy and adenine models显示文摘 | Ferrari GO Ferreira JC Cavallari RT | 2014 | BMC Nephrol2014，37，15： | 1 |
| 8 | Slatin therapy and risks for death and hospitalization in chronic heart failure显示文摘 | Go AS Lee WY Yang J Lo JC | 2006 | JAMA2006，296，17： | 1 |
| 9 | Epidemiology of non-dialysis-requiring chronic kidney disease and cardiovascular disease显示文摘 | Go AS Lo JC | 2006 | Curt Opin Nephrol Hypertens2006，15，3： | 1 |
| 10 | Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease显示文摘 | Lo JC Chertow GM Go AS | | 0，，03： | 1 |
| 11 | Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease显示文摘 | Lo JC Chcow GM Go AS ct al | 2005 | Kidney Int2005，67，3： | 1 |
| 12 | The efficacy of epidural anes-thesia for endoscopic preperitoneal herniorrhaphy : a prospectivestudy 显示文摘 | Azurin DJ Go LS Cwik JC | 1996 | J Laparoendosc Surg1996，6，6： | 1 |
| 13 | Detection of groin hernia with physical examination,ultrasound,and MRI compared with laparoscopic findings显示文摘 | van den Berg JC de Valois JC Go PM | 1999 | Invest Radiol1999，34，12： | 1 |
| 14 | Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16)显示文摘 | Russell JC Amy RM Graham SE Dolphin PJ Wood GO Bar-Tana J | 1995 | Arterioscler Thromb Vasc Biol1995，15，： | 1 |
| 15 | Breast implant stability in the subfascial plane and the new shaped silicone gel breast implants 显示文摘 | Sampaio GO es JC | 2010 | AesthetPlastSurg2010，34，1： | 1 |
| 16 | GFR, body mass index, and low high-density lipoprotein concentration in adults with and without CKD 显示文摘 | Lo JC Go AS Chandra M | 2007 | Am J Kidney Dis2007，50，4： | 1 |
| 17 | Increased prevalence of sub- clinical and clinical hypothyroidism in persons with chronic kid- ney disease 显示文摘 | Lo JC Chertow GM Go AS | 2005 | Kidney Int2005，67，3： | 1 |
| 18 | Radiological anatomy of the groin region显示文摘 | van den Berg JC de Valois JC Go PM etal | 2000 | Eur Radiol2000，10，4： | 1 |
| 19 | The efficacy of epidural anesthesia for endoscopic preperitoneal herniorrhaphy: a prospective study 显示文摘 | Azurin DJ Go LS Cwik JC Schuricht AL | 1996 | J Laparoendosc Surg1996，6，6： | 1 |
| 20 | Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease 显示文摘 | Lo JC Chertow GM Go AS | 2005 | Kidney Int2005，67，3： | 1 |
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