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| 1 | Effects of protein deprivation and re-feeding on P2X_2 receptors in enteric neurons显示文摘AIM:To investigate the effects of malnutrition and refeeding on the P2X2 receptor,nitric oxide synthase(NOS),calretinin,calbindin and choline acetyltransferase(ChAT) in neurons of the rat ileum.METHODS:We analyzed the co-localization,numbers and sizes of P2X2-expressing neurons in relation to NOS-immunoreactive(IR),calbindin-IR,ChAT-IR,and calretinin-IR neurons of the myenteric and submucosal plexus.The experimental groups consisted of:(1) rats maintained on normal feed throughout pregnancy until 42 d post-parturition(N);(2) rats deprived of protein throughout pregnancy and 42 d post-parturition(D);and(3) rats undernourished for 21 d post-parturition and then given a protein diet from days 22 to 42(DR).The myenteric and submucosal plexuses were evaluated by double labeling by immunohistochemical methods for P2X2 receptor,NOS,ChAT,calbindin and calretinin.RESULTS:We found similar P2X2 receptor immunoreactivity in the cytoplasm and surface membranes of myenteric and submucosal neurons from the N,D and DR groups.Double labeling of the myenteric plexus demonstrated that approximately 100% of NOS-IR,calbindin-IR,calretinin-IR and ChAT-IR neurons in all groups also expressed the P2X2 receptor.In the submucosal plexus,the calretinin-IR,ChAT-IR and calbindin-IR neurons were nearly all immunoreactive for the P2X2 receptor.In the myenteric plexus,there was a 19% increase in numbers per cm2 for P2X2 receptor-IR neurons,64% for NOS-IR,84% for calretinin-IR and 26% for ChAT-IR neurons in the D group.The spatial density of calbindin-IR neurons,however,did not differ among the three groups.The submucosal neuronal density increased for calbindin-IR,calretinin-IR and ChAT-IR neurons.The average size of neurons in the myenteric plexus neurons in the D group was less than that in the controls and,in the re-fed rats;there was a 34% reduction in size only for the calretinin-IR neurons.CONCLUSION:This work demonstrates that expression of the P2X2 receptor is present in inhibitory,intrinsic primary afferent,cholinergic secretomotor and vasomotor neurons.Undernutrition affected P2X2 receptor expression in the submucosal plexus,and neuronal and size.These changes were rescued in the re-fed rats. | Rúbia Misawa Priscila Azevedo Girotti Márcia Sanae Mizuno Edson Aparecido Liberti John Barton Furness Patricia Castelucci | 2010 | World Journal of Gastroenterology2010，16，29： | 2 |
| 2 | Involvement of preexisting lipid hydroperoxides in Cu(2+)-stimulated oxidation of low-density lipoprotein显示文摘 | THOMAS J P KALYANARAMAN B GIROTTI A W | 1994 | Arch Biochem Biophys1994，315，2： | 1 |
| 3 | Chronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain显示文摘 | Girotti M Donegan J J Morilak D A | 2011 | Psychoneuroendocrinology2011，36，8： | 1 |
| 4 | ALPPS in right trisectionectomy: a safe procedure to avoid postoperative liver failure?显示文摘 | Li J Girotti P K6nigsrainer I | 2013 | J Gastrointest Surg2013，17，5： | 1 |
| 5 | Spontaneous transfer of phospholipid and cholesterol hydroperoxides between cell membranes and low-density lipoprotein: assess- ment of reaction kinetics and prooxidant effects 显示文摘 | Vila A Korytowski W Girotti A W | 2002 | Biochemistry2002，41，13： | 1 |
| 6 | ALPPS in right trisectionectomy:a safe procedure to provide postoperative liver failure显示文摘 | Li J Girotti P Konigsrainer I | | 0，，05： | 1 |
| 7 | Iatrogenic intramuraldissection of the gallbladder wall can mimic post-ERCP cholecys-titis 显示文摘 | Girotti ME Gupta N Schirmer BD | 2007 | Endoscopy2007，39，1： | 1 |
| 8 | Signaling events in apoptotic photokilling of 5-aminolevulinic acid-treated tumor cells:Inhibitory effects of nitric oxide 显示文摘 | Bhowmick R Girotti'AW | 2009 | Free Radio Biol Meal2009，47，6： | 1 |
| 9 | Lipolytic activity of cirsimarin extracted from Microtea debilis 显示文摘 | GIROTTI C GINET M DEMAME F C | 2005 | Planta Medica2005，71，12： | 1 |
| 10 | Gene expression profiling of rat uterus at different stages of parturition 显示文摘 | Girotti M Zingg H H | 2003 | Endocrinnol2003，144，6： | 1 |
| 11 | Monitoringofenvironmentalpollutantsbybioluminescentbacteria显示文摘 | GirottiS FerriEN FumoMG etal | 2008 | AnalyticaChimicaActa2008，608，1： | 1 |
| 12 | No longer an untreatable disease:How targeted and immunotherapies have changed the management of melanoma patients 显示文摘 | GIROTTI M R SATURNO G LORIGAN P | 2014 | Mol Oncol2014，8，6： | 1 |
| 13 | Paradox - breaking RAF inhibitors that also target SRC are effective in drug - resistant BRAF mutant melanoma显示文摘 | Girotti MR Lopes F Preece N | 2015 | Cancer Ce112015，27，1： | 1 |
| 14 | Lipid hydroperoxide generation,turnover,and effector action in biological systems显示文摘 | Girotti AW | 1998 | J Lipid Res1998，39，8： | 1 |
| 15 | ALPPS in Right Trisectionectomy:a Safe Procedure to Avoid Postoperative Liver Failure? 显示文摘 | Li J Girotti P Konigsrainer I | 2013 | Journal of Gastrointestinal Surgery2013，17，5： | 1 |
| 16 | ALPPS in right trisectionec- tomy: a safe procedure to avoid postoperative liver failure? 显示文摘 | Li J Girotti P K6nigsrainer I | 2013 | J Gastrintest Surg2013，17，5： | 1 |
| 17 | Pentoxifylline doesnot prevent microvascular injury in normotensive,septic rats显示文摘 | Flammand FJ Sibbald WJ Girotti MJ etal | 1995 | Crit Care Med1995，23，1： | 1 |
| 18 | Photosensitized oxidation of membrane lipids:reaction pathways, cytotoxic effects, and cytoprotectivemechanisms 显示文摘 | Girotti A W | 2001 | J Photochem Photobiol B2001，63，13： | 1 |
| 19 | Olivopontocerebellar atro phy: MR diagnosis and relationship to muhiple system atrophy 显示文摘 | Savoiardo M Strada L Girotti F | 1990 | Radiology1990，174，3： | 1 |
| 20 | Monitoring of environmental pollutants by bioluminescent bacteria显示文摘 | Girotti S Ferri E N Fumo M G | 2008 | Analytica Chimica Acta2008，608，1： | 1 |
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