|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Trefoil factors:Tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma显示文摘AIM:To investigate trefoil factor(TFF) gene copy number,mRNA and protein expression as potential biomarkers in cholangiocarcinoma(CCA).METHODS:TFF mRNA levels,gene copy number and protein expression were determined respectively by quantitative reverse transcription polymerase chain reaction(PCR),quantitative PCR and immunohistochemistry in bile duct epithelium biopsies collected from individuals with CCA,precancerous bile duct dysplasia and from disease-free controls.The functional impact of recombinant human(rh) TFF2 peptide treatment on proliferation and epidermal growth factor receptor(EGFR) /mitogenactivated protein kinase(MAPK) signaling was assessed in the CCA cell line,KMBC,by viable cell counting and immunoblotting,respectively.RESULTS:TFF1,TFF2 and TFF3 mRNA expression was significantly increased in CCA tissue compared to disease-free controls,and was unrelated to gene copy number.TFF1 immunoreactivity was strongly increased in both dysplasia and CCA,whereas TFF2 immunoreactivity was increased only in CCA compared to diseasefree controls.By contrast,TFF3 immunoreactivity was moderately decreased in dysplasia and further decreased in CCA.Kaplan-Meier analysis found no association of TFF mRNA,protein and copy number with age,gender,histological subtype,and patient survival time.Treatment of KMBC cells with rhTFF2 stimulated proliferation,triggered phosphorylation of EGFR and downstream extracellular signal related kinase(ERK),whereas co-incubation with the EGFR tyrosine kinase inhibitor,PD153035,blocked rhTFF2-dependent proliferation and EGFR/ERK responses.CONCLUSION:TFF mRNA/protein expression is indicative of CCA tumor progression,but not predictive for histological sub-type or survival time.TFF2 is mitogenic in CCA via EGFR/MAPK activation. | Kanuengnuch Kosriwong Trevelyan R Menheniott Andrew S Giraud Patcharee Jearanaikoon Banchob Sripa Temduang Limpaiboon | 2011 | World Journal of Gastroenterology2011，17，12： | 16 |
| 2 | Urine-derived stem/progenitor cells:A focus on their characterization and potential显示文摘Cell therapy,i.e.,the use of cells to repair an affected tissue or organ,is at the forefront of regenerative and personalized medicine.Among the multiple cell types that have been used for this purpose[including adult stem cells such as mesenchymal stem cells or pluripotent stem cells],urine-derived stem cells(USCs)have aroused interest in the past years.USCs display classical features of mesenchymal stem cells such as differentiation capacity and immunomodulation.Importantly,they have the main advantage of being isolable from one sample of voided urine with a cheap and unpainful procedure,which is broadly applicable,whereas most adult stem cell types require invasive procedure.Moreover,USCs can be differentiated into renal cell types.This is of high interest for renal cell therapy-based regenerative approaches.This review will firstly describe the isolation and characterization of USCs.We will specifically present USC phenotype,which is not an object of consensus in the literature,as well as detail their differentiation capacity.In the second part of this review,we will present and discuss the main applications of USCs.These include use as a substrate to generate human induced pluripotent stem cells,but we will deeply focus on the use of USCs for cell therapy approaches with a detailed analysis depending on the targeted organ or system.Importantly,we will also focus on the applications that rely on the use of USC-derived products such as microvesicles including exosomes,which is a strategy being increasingly employed.In the last section,we will discuss the remaining barriers and challenges in the field of USC-based regenerative medicine. | Perrine Burdeyron Sébastien Giraud Thierry Hauet Clara Steichen | 2020 | World Journal of Stem Cells2020，12，10： | 6 |
| 3 | Targeting STAT3 in gastric cancer显示文摘 | Andrew S Giraud Trevelyan R Menheniott Louise M Judd | 2012 | Expert Opinion on Therapeutic Targets2012，，9： | 3 |
| 4 | 树突状细胞自然杀伤细胞凝集素群受体1促进小鼠动脉粥样硬化的发展显示文摘动脉粥样硬化发展过程中的坏死核心形成与慢性炎症反应有关,其促进斑块发展加快和不稳定。然而,坏死与动脉粥样硬化发展之间的分子生物学联系机制尚未完全清楚。 | 刘莉 叶鹏 Haddad Y Lahoute C Clément M Laurans L Metghalchi S Lynda Z Giraud A Loyer X Vandestienne M Wain-Hobson J Esposito B Potteaux S Ait-Oufella H Tedgui A Mallat Z Taleb S | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 5 | Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery 显示文摘 | Preville X Salvemini F Giraud S | 1999 | Exp Cell Res1999，247，1： | 1 |
| 6 | Polypropyl- ene fabrics padded with microencapsulated ammonium phate: Effect of the shell structure on the thermal stability and fire performance 显示文摘 | VROMAN I GIRAUD S SALAI3N F | 2010 | Polym Degrad Stab2010，95，9： | 1 |
| 7 | Isolation and physiological study of an amylolytic strain of Lactobacillus plantarum 显示文摘 | GIRAUD E BRAUMAN A KELEKE S | 1991 | Appl Microbiol Biotechnol1991，36，： | 1 |
| 8 | Kidney protection by hypothermic total liquid ventilation after cardiac arrest in rabbits显示文摘 | Tissier R Giraud S Quellard N | 2014 | Anesthesiology2014，120，4： | 1 |
| 9 | An update on mutations of the SLC39A4 gene in acrodermatitis enteropathica显示文摘 | Schmitt S Küry S Giraud M | 2009 | Hum Mutat2009，30，6： | 1 |
| 10 | Fire performances comparison of back coating and melt spinning approaches for PET covering textiles 显示文摘 | DIDANE N GIRAUD S DEVAUX E | 2012 | Polymer Degra- dation2012，97，： | 1 |
| 11 | Expression of human ANT2 gene in highly proliferative cells: GRBOX, a new transcriptional element, is involved in the regulation of glycolytic ATP import into mitochondria 显示文摘 | Giraud S Bonod-Bidaud C Wesolowski-Louvel M | 1998 | J Molec Biol1998，281，40： | 1 |
| 12 | The PprA-PprB two-component system activates CupE, the first non-archetypalPseudomonas aeruginosa chaperone-usher pathway system assembling fimbriae显示文摘 | Giraud C Bernard C S Calderon V Yang L Filloux A Molin S Fichant G Bordi C de Bentzmann S | 2011 | Environmental Microbiology2011，13，3： | 1 |
| 13 | Poly- propylene fabrics padded with microencapsula- ted ammonium phosphate:Effect of the shell structure on the thermal stability and fire per- formance 显示文摘 | Vroman I Giraud S Bourbigot S | 2010 | Polymer Degradation and Stabil- ity2010，95，9： | 1 |
| 14 | Intravenous hypertrophic paccioni granulations:differentiation from venous dural thrombosis显示文摘 | Giraud P Thobois S Hermier M | 2001 | J Neurol Neurosurg Psychiatry2001，70，5： | 1 |
| 15 | Parallel Tools for Solving Incremental Dense Least Squares Problems: Application to Space Geodesy显示文摘 | Baboulin M Giraud L Gratton S | 2009 | Jour- nal of Algorithms : Computational Technology2009，3，1： | 1 |
| 16 | Resistance to fluoroquinolones in Salmonella:emerging mechanisms and resistance prevention strategies显示文摘 | Giraud E Baucheron S Cloeckaert A | | 0，，7： | 1 |
| 17 | Understanding the deafened brain:Implications for cochlear implant rehabilitation显示文摘 | LAZARD D S GIRAUD A L GNANSIA D | 2012 | Eur Ann Otorhinolaryngol Head Neck Dis2012，129，： | 1 |
| 18 | Microencapsulation of ammonium phosphate with a polyurethane shell part I: Coacervation technique显示文摘 | Saihi D Vroman I Giraud S | 2005 | Reactive & Functional Poly- mers2005，64，： | 1 |
| 19 | Parallel Tools for Solving Incremental Dense Least Squares Problems: Application to Space Geodesy显示文摘 | BABOULIN M GIRAUD L GRATTON S | 2009 | Journal of Algorithms & Computational Technology2009，3，1： | 1 |
| 20 | Mieroencapsalation of ammonium phosphate with a polyurethane shell 显示文摘 | SAIHI D VROMAN I GIRAUD S | 2006 | Reactive & Functional Polymers2006，66，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员