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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Thin film dissolved oxygen sensor based on platinum octaethylporphyrin encapsulated in an elastic fluorinated polymer 显示文摘 | Gillanders R N Tedford M C Crilly P J | 2004 | Anal Chim Acta2004，502，1： | 1 |
| 3 | Boiling frogs: Pricing strategies for a manufacturer adding a direct channel that competes with the traditional channel 显示文摘 | CATTANIK GILLAND W HEESE H | 2006 | Production and Operations Man- agement2006，15，1： | 1 |
| 4 | Interactive effects of temperature and salinity on otolithchemistry:challenges for determining environmental histories of fish显示文摘 | Elsdon Travis S Gillanders Bronwyn M | 2002 | Canadian Journal of Fish-eries and Aquatic Sciences2002，59，： | 1 |
| 5 | Boiling frogs: Pricing strategies for a manufacturer adding a direct channel that competes with the traditional channel显示文摘 | Kyle Cattani Wendell Gilland Hans Sebastian Heese and Jayashankar Swaminathan | 2006 | Production and Operations Management2006，15，1： | 1 |
| 6 | Sentinel lymph node bi- opsy in patients with muhicentric/mutifocal breast cancer:low fasle negative rate and lack of axillary recurrence 显示文摘 | Holwitt DM Gillander WE Aft RL | 2008 | Am J Surg2008，196，4： | 1 |
| 7 | Evidence of connectivity between juvenile and adult habitats for mobile marine fauna:an important component of nurseries显示文摘 | GILLANDERS B ABLE K BROWN J | 2003 | Marine Ecology Progress Series2003，247，1： | 1 |
| 8 | Emotion regulalion affect, psychosocial functioning, and well-being in hemodialysis patients显示文摘 | Gillanders S Wild M Deighan C | 2008 | Am J Kidney Dis2008，51，： | 1 |
| 9 | Revenue management for outpatient appointments: Joint capacity control and overbooking with class-dependent no-shows显示文摘 | Ratcliffe A Gilland W Marucheck A | 2012 | Flexible Services and Manufacturing Journal2012，24，4： | 1 |
| 10 | Approaches to resolving cephalopod movement and migration patterns显示文摘 | SEMMENS J M PECL G T GILLANDERS B M | 2007 | Reviews in Fish Biology Fisheries2007，17，23： | 1 |
| 11 | Analysis of cytokine mRNA and DNA: Detection and quantitation by competitive polymerase chain reaction 显示文摘 | Gilland Preein Blanchard | 1990 | Proc Natl Acad Sci USA1990，87，： | 1 |
| 12 | Progressive juvenile- onset punctate cataracts caused by mutation of the gammaD-crystallin gene显示文摘 | Stephan DA Gillanders E Vanderveen D | 1999 | Proc Natl Acad Sci U S A1999，96，： | 1 |
| 13 | Management of cervi- cal nodal metastasis detected on 1-131 scintigraphy after initial sur- gery of well-differentiated thyroid carcinoma显示文摘 | Creach KM Gillanders WE Siegel BA | 2010 | Surgery2010，148，6： | 1 |
| 14 | Boiling Frogs: Pricing Strategies for a Manufacturer Adding a Direct Channel that Competes with Traditional Channel 显示文摘 | Cattani K D Gilland W Swanminathan J M | 2006 | Production and Operation Management2006，15，1： | 1 |
| 15 | Boiling frogs pricing strategies for a manufacturer adding a direct channel that competes with the traditional channel 显示文摘 | Cattanik K Gilland W Heese H S | 2006 | Production and Operations Management2006，15，1： | 1 |
| 16 | Mitigating Supply Risk: Dual Sourcing or Process Improvement 显示文摘 | WANG Y GILLAND W TOMLIN B | 2010 | Manufacturing & Service Operations Manage- ment2010，12，3： | 1 |
| 17 | Boiling frogs:pricing strategies for a manufacturer adding a direct channel that competes with the traditional channel显示文摘 | Cattani K D Gilland W G Swaminathan J M | 2009 | Production and Operations Management2009，15，1： | 1 |
| 18 | The development and initia| validation of the cognitive fusion questionnaire 显示文摘 | GILLANDERS DT BOLDERSTON H BOND FW | 2014 | Behav Ther2014，45，1： | 1 |
| 19 | Molecular detection of micrometastatic breast cancer in histopathology-negative axillary lymph nodes correlates with traditional predictors of prognosis:an interim analysis of a prospective multi-institutional cohort study显示文摘 | Gillanders W E Mikhitarian K Hebert R | 2004 | Ann Surg2004，239，6： | 1 |
| 20 | Mitigating supply risk: Dual sourcing or process improvement? 显示文摘 | Wang Y Gilland W Tomlin B | 2010 | Manufacturing and service operation management2010，12，3： | 1 |
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